- Häftad (Paperback / softback)
- Antal sidor
- LAP Lambert Academic Publishing
- black & white illustrations
- 229 x 152 x 12 mm
- Antal komponenter
Du kanske gillar
C-Terminal Domains of Vegf-A Dictate Its Biological Properties
Th role of VEGF-A isoforms in angiogenesis and cancer499Skickas inom 10-15 vardagar.
Fri frakt inom Sverige för privatpersoner.VEGF-A is a crucial growth factor for blood vessels homeostasis and pathological angiogenesis. It is produced under different isoforms resulting from a dynamic mechanism of alternative splicing affecting the 3'-half of its primary transcript. Although the implicated protein domains are not involved in binding to its receptors, they strongly influence the VEGF biological activity by regulating its availability, structure and affinity for co-receptors. This work aimed at a better understanding of the functions and the cooperation between the C-terminal domains of VEGF-A as controversies still exist about their specific roles, especially the antiangiogenic function of the exon 8b-derived sequence. We engineered 8 different expression constructs all containing the sequences of exons 1-4 followed by various combinations of exons 5, 7 and 8a or b. We tested their properties in several models in vitro and in vivo. The experiments described in this manuscript allow us to decipher the role of the C-terminal domain of VEGF-A in receptors binding, angiogenesis and cancerd development.
Passar bra ihop
De som köpt den här boken har ofta också köpt Urokinase receptor (uPAR) and integrin interact... av Revu Alexander (häftad).Köp båda 2 för 1038 kr
KundrecensionerHar du läst boken? Sätt ditt betyg »