Effect of nebivolol, carvedilol and metoprolol on doxorubicin-cardiotox (häftad)
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Format
Häftad (Paperback / softback)
Språk
Engelska
Antal sidor
148
Utgivningsdatum
2015-05-06
Förlag
LAP Lambert Academic Publishing
Medarbetare
Khattab Aida Abdallah / El-Aziz Sadek Sawsan Abd
Illustrationer
black & white illustrations
Dimensioner
229 x 152 x 9 mm
Vikt
227 g
Antal komponenter
1
Komponenter
Paperback
ISBN
9783659435652
Effect of nebivolol, carvedilol and metoprolol on doxorubicin-cardiotox (häftad)

Effect of nebivolol, carvedilol and metoprolol on doxorubicin-cardiotox

A comparative study of cardio protective activity of beta-blockers on doxorubicin-induced cardiac toxicity in rats

Häftad Engelska, 2015-05-06
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A comparative study of cardio protective activity of nebivolol, carvedilol and metoprolol was carried out on doxorubicin-induced cardiac toxicity in rats. The degree of protection was assessed both in vivo by short axis echocardiography measuring ejection fraction (EF), fractional shortening (FS), left ventricular systolic diameter (LVSD) and left ventricular diastolic diameter (LVDD) and in vitro by measuring the inotropic and the chronotropic responses to isoproterenol. Also histopathlogical study was done. This study revealed that there is a significant improvement of cardiac functions in rats treated with -blockers and there is no significant difference between carvedilol and nebivolol whereas nebivolol has the best histopathological score for improvement cardiac toxicity.
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