Influence of Piperin on Pioglitazone Metabolism and Pk/Pd (häftad)
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Format
Häftad (Paperback / softback)
Språk
Engelska
Antal sidor
80
Utgivningsdatum
2014-07-10
Förlag
LAP Lambert Academic Publishing
Medarbetare
Sunil Reddy / Rajitha Koppula
Illustrationer
black & white illustrations
Dimensioner
229 x 152 x 5 mm
Vikt
127 g
Antal komponenter
1
Komponenter
Paperback
ISBN
9783659553011

Influence of Piperin on Pioglitazone Metabolism and Pk/Pd

Diabetes

av Begum Fahmeeda, Sunil Reddy, Rajitha Koppula
Häftad,  Engelska, 2014-07-10
580
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Several factors directly or indirectly influence the CYP activity. CYP mediated metabolism are likely to be potential candidates for drug interaction.Many drug interactions are a result of induction or inhibition of CYP enzymes. Herbal medicines that modulate intestinal and hepatic CYPs can alter the bioavailability and clearance of co -administered drugs. The diabetic patients have reduced immune system where as Piperine which have significant immunomodulatory activity. Hence, the combination has a beneficial effect in diabetic condition in view of the side effects of pioglitazone.Hence, the combination has a beneficial effect in diabetic condition, but special concern has to be observed in diabetic patients with cardiovascular complications in view of the side effects of pioglitazone. Hence the present investigation warrants further studies to find out the relevance of this interaction in human beings and postulates the exact mechanism involved.
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