Female sex and ER-alpha modulate cardiac ischaemic remodeling (häftad)

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Medicin: allmänt

Format: Häftad (Paperback / softback)
Språk: Engelska
Antal sidor: 92
Utgivningsdatum: 2015-07-03
Förlag: Sudwestdeutscher Verlag Fur Hochschulschriften AG
Illustrationer: Illustrations, black and white
Dimensioner: 229 x 152 x 6 mm
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Antal komponenter: 1
Komponenter: 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam
ISBN: 9783838151281

Female sex and ER-alpha modulate cardiac ischaemic remodeling

Name: Female sex and ER-alpha modulate cardiac ischaemic remodeling
Price: 863.00 SEK
Availability: InStock
Author: Xiang Zhang
ISBN: 9783838151281

Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice

av Xiang Zhang

Häftad, Engelska, 2015-07-03

863

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In this study, we present novel insights into mechanisms that account for the ER-dependent myocardial protection against myocardial injury, with more beneficial effects in female hearts. Using a transgenic mouse model with a cardiomyocyte-specific ER-overexpression (ER-OE), we first demonstrated that this was associated with an increase of LVM at the basal level in both female and male mice. After MI, the cardiomyocyte-specific ER-OE inhibited changes in LV-volumes and wall thickness only in female mice. These beneficial effects in female ER-OE hearts were associated with increased angiogenesis and lymphangiogenesis, attenuated ventricular fibrosis and enhanced JNK phosphorylation. This study indicates that in the female sex, ER in cardiomyocytes may have a therapeutic potential in the treatment of ischemic heart disease, leading to more efficient cardiac repair after ischemic injury.

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