Zinc Sulphate Matrices for the Individual Therapy of Wilson's Disease (häftad)
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Format
Häftad (Paperback / softback)
Språk
Engelska
Antal sidor
76
Utgivningsdatum
2010-06-06
Förlag
LAP Lambert Academic Publishing
Medarbetare
Nagy, Judit / Zelko, Romana
Illustrationer
black & white illustrations
Dimensioner
229 x 152 x 5 mm
Antal komponenter
1
Komponenter
Paperback
ISBN
9783838370293
Zinc Sulphate Matrices for the Individual Therapy of Wilson's Disease (häftad)

Zinc Sulphate Matrices for the Individual Therapy of Wilson's Disease

Preparation and evaluation of zinc sulphate matrices

Häftad Engelska, 2010-06-06
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Zinc is now one of the recommended therapies for the long-term management of Wilson's disease. Zinc has shown clinical efficacy at doses of 50 mg three times daily in the stimulation of metallothionein synthesis and reduction of copper absorption. The mean plasma elimination half-lives of most highly water soluble drugs, like zinc sulphate, are relatively short (2-4.5 h), which necessitates several applications a day. Long-acting sustained and controlled release preparations make a once-a-day dose treatment possible, thus improving the patients' compliance. The rate and extent of drug release from most controlled release wax matrices are influenced by several factors including the drug loading/embedding excipient ratio of the systems. The changing of this ratio enabled the preparation of zinc sulphate wax matrices of required drug release kinetics consequently of plasma zinc level.
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