Anti-Angiogenesis Chemotherapy Agents (häftad)
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Format
Häftad (Paperback / softback)
Språk
Engelska
Antal sidor
80
Utgivningsdatum
2011-09-01
Förlag
LAP Lambert Academic Publishing
Illustrationer
black & white illustrations
Dimensioner
229 x 152 x 5 mm
Vikt
127 g
Antal komponenter
1
Komponenter
Paperback
ISBN
9783845420097
Anti-Angiogenesis Chemotherapy Agents (häftad)

Anti-Angiogenesis Chemotherapy Agents

The role of anti-angiogenesis at cancer treatment

Häftad Engelska, 2011-09-01
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Angiogenesis can be explained as the growth of new blood vessels from pre-existing vasculature. It has an important and vital role in growth and development, as well as in wound healing. Anti-angiogenic substances suppress the growth of new blood vessels so prevent nutrients and oxygen needed for the growing of tumor cells. It is proposed that tumor angiogenesis could serve as a potential target for anticancer therapy. Combretastatin (CA-4) is an anti-angiogenesis agent that inhibits the tubulin polymerization. CA-4 exhibits anti-tumor effects through the well-organized therapeutic mechanism of tumor blood supply disabling. By affecting selectively and blocking tumor vasculature, CA-4 reduces the blood supply needed for tumor growth and survival. As a result of oxygen poverty and build-up of tumor metabolic by-products causes the death of the cancer cells within the central core of the tumor. In this thesis, covalent modification of CA-4 has been investigated. Variety of CA-4 analogs which involved blocking the free alcohol group has been synthesized.
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  1. Anti-Angiogenesis Chemotherapy Agents
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  3. Angiogenesis Modulations in Health and Disease

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