Anti-Angiogenesis Chemotherapy Agents (häftad)

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Format: Häftad (Paperback / softback)
Språk: Engelska
Antal sidor: 80
Utgivningsdatum: 2011-09-01
Förlag: LAP Lambert Academic Publishing
Illustrationer: black & white illustrations
Dimensioner: 229 x 152 x 5 mm
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Antal komponenter: 1
Komponenter: Paperback
ISBN: 9783845420097

Anti-Angiogenesis Chemotherapy Agents

Name: Anti-Angiogenesis Chemotherapy Agents
Price: 688.00 SEK
Availability: InStock
Author: Duygu Citak
ISBN: 9783845420097

The role of anti-angiogenesis at cancer treatment

av Duygu Citak

Häftad, Engelska, 2011-09-01

688

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Angiogenesis can be explained as the growth of new blood vessels from pre-existing vasculature. It has an important and vital role in growth and development, as well as in wound healing. Anti-angiogenic substances suppress the growth of new blood vessels so prevent nutrients and oxygen needed for the growing of tumor cells. It is proposed that tumor angiogenesis could serve as a potential target for anticancer therapy. Combretastatin (CA-4) is an anti-angiogenesis agent that inhibits the tubulin polymerization. CA-4 exhibits anti-tumor effects through the well-organized therapeutic mechanism of tumor blood supply disabling. By affecting selectively and blocking tumor vasculature, CA-4 reduces the blood supply needed for tumor growth and survival. As a result of oxygen poverty and build-up of tumor metabolic by-products causes the death of the cancer cells within the central core of the tumor. In this thesis, covalent modification of CA-4 has been investigated. Variety of CA-4 analogs which involved blocking the free alcohol group has been synthesized.

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