Snake Venoms (inbunden)
Inbunden (Hardback)
Antal sidor
1st ed. 2017
Gopalakrishnakone, P. (ed.-in-chief)
5 schwarz-weiße Tabellen 15 schwarz-weiße und 15 farbige Abbildungen Bibliographie
48 Tables, color; 5 Tables, black and white; 57 Illustrations, color; 30 Illustrations, black and wh
234 x 158 x 31 mm
1156 g
Antal komponenter
1 Hardback
Snake Venoms (inbunden)

Snake Venoms

Inbunden Engelska, 2016-12-01
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Initially, because of the inadequate sensitivity of devices and other limitations, only major venom components of the dominant species were studied. However, in last two decades, increased sensitivity of devices and the development of new techniques, such as transcriptomics and proteomics techniques, have permitted us to analyze the structures and functions of rare species and to identify novel minor components. As a result, the number of venom components identified is increasing dramatically and the physiological functions of each component is more deeply understood. The scope of this book provides the readers an updated and comprehensive presentation on snake venoms. The subjects are divided into six sections, starting with the overview of snake venom compositions in Malaysian species, followed by description of enzymes and enzyme inhibitors contained in snake venoms. Also discussed are the effects of snake venom on cellular receptors, ion channels, blood, and lymph, as well as cytotoxic and antimicrobial molecules present in snake venoms. The last section covers the clinical consequences of envenomation and the management of snakebites using antivenins.
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P. Gopalakrishnakone, M.B.B.S., Ph.D., F.A.M.S., D.Sc., is professor of anatomy and chairman of the Venom and Toxin Research Programme at Yong Loo Lin School of Medicine, National University of Singapore, where he has become an emeritus professor. In addition, he also has assumed the position of professor of anatomy at the Singapore Institute of Technology, Health and Social Sciences Cluster. Prof. Gopalakrishnakone is also a consultant to the Defence Science Organization in Singapore; adjunct senior research scientist at the Defence Medical Research Institute; and an honorary principal fellow at the Australian Venom Research Unit, University of Melbourne, Australia. His research studies include structure function studies, toxin detection, biosensors, antitoxins and neutralization factors, toxicogenomics and expression studies, antimicrobial peptides from venoms and toxins, and PLA2 inhibitors as potential drug candidates for inflammatory diseases. The techniques he employs include quantum dots to toxinology, computational biology, microarrays, and protein chips. Prof. Gopalakrishnakone has more than 160 international publications, four books, about 350 conference presentations, and 10 patent applications. He has been an active member of the International Society on Toxinology (IST) for 30 years and was president from 2008 to 2012. He is also the founder president of its Asia Pacific Section, a council member, as well as an editorial board member of Toxicon, the society's official journal. His research awards include the Outstanding University Researcher Award from the National University of Singapore (1998); Ministerial Citation, NSTB Year 2000 Award in Singapore; and the Research Excellence Award from the Faculty of Medicine at NUS (2003). His awards in teaching include Faculty Teaching Excellence Award 2003/4 and NUS Teaching Excellence Award 2003/4. Prof. Gopalakrishnakone also received the Annual Teaching Excellence Award in 2010 at both university and faculty levels. Hidetoshi Inagaki is senior researcher at the National Institute of Advanced Industrial Science and Technology, in Japan, since 2001, working on the bioactive peptides of venomous animals, such as snakes and ants. During that time, from April 2006 to March 2007, he worked at CSTP (Council for Science and Technology Policy) on the "Guidelines on the Derivation and Distribution of Human Embryonic Stem Cells" and other science policies. From April 1994 to March 2001, Inagaki was a researcher at the National Industrial Research Institute of Nagoya, Japan. Inagaki received his Ph.D. from Nagoya University, Japan, in 1994, with time spent in Beth Israel Hospital, Boston, United States, from August 1991 to March 1992. He was also a graduate (April 1989 -March 1991) and an undergraduate (April 1984-March 1989) at Nagoya University, Japan. For last five years, his research group has been working on the directed evolution of bioactive peptides. Using directed evolution, the group could generate agonist and antagonist like molecules of receptors, and enzyme inhibitors. Carl-Wilhelm Vogel received his M.D. degree and Ph.D. degree in biochemistry from the University of Hamburg in Germany. For three-and-a-half years, Dr. Vogel was a postdoctoral research fellow in molecular immunology at Scripps Clinic and Research Foundation in La Jolla, California. He completed a medical internship in Germany and four years of residency training in clinical pathology at Georgetown University in Washington, D.C., and at Indiana University/Purdue University in Indianapolis. He is a licensed physician and a board-certified clinical pathologist both in the USA and Germany. He was on the faculty of Georgetown University School of Medicine for approximately nine years in the Departments of Biochemistry and Molecular Biology and Internal Medicine, and a member of the Lombardi Cancer Center, before assuming the chairmanship of the Department of Biochemistry and Molecular Biology a


Toxinology of Snake Venoms: The Malaysian Context. - Cellular Mechanisms of Action of Snake Phospholipase A2 Toxins. - Secreted Phospholipases A2 with -Neurotoxic Activity. - Anticoagulant and Membrane Damaging Properties of Snake Venom Phospholipase A2 Enzymes. - Phospholipase A2 Inhibitors from Snake Blood (sbPLIs). - A Brief Appraisal on Russell's Viper Venom (Daboia russelii russelii) Proteinases. - Endothelial Cell Toxicity of Vascular Apoptosis-Inducing Proteins from Hemorrhagic Snake Venom. - Snake Venom Protease Inhibitors: Enhanced Identification, Expanding Biological Function, and Promising Future. - Snake Venom Toxins Targeted at the Nervous System. - Snake -neurotoxins and the Nicotinic Acetylcholine Receptor. - Structural and Functional Diversity of Snake Sarafotoxins. - Crotamine: Function Diversity and Potential Applications. - Vipericidins, Snake Venom Cathelicidin-Related Peptides, in the Milieu of Reptilian Antimicrobial Polypeptides. - Cytotoxic Effects of Snake Venoms. - Cobra Venom Factor: The Unique Component of Cobra Venom That Activates the Complement System. - Non-Cobra Venom Factor Venom Components Acting on Complement Proteins. - Snake Venom Components Affecting the Coagulation System. - Snake Venom Disintegrins. - Role of Lymphatic System on Snake Venom Absorption. - Antivenom Safety and Tolerance for the Strategy of Snake Envenomation Management.