Algebra of Organic Synthesis

John Andraos earned a Ph.D. in 1992 from the University of Toronto in physical organic chemistry. Since his appointment as Lecturer and Course Director at York University, he launched the first industrial and "green" chemistry course in the history of the Department of Chemistry. He has done consulting assignments with the pharmaceutical industry on various aspects of synthesis optimization and green chemistry education. His research spans several disciplines in organic chemistry which utilize mathematical analysis including reaction kinetics, retrosynthesis and synthesis planning, and the creation of reaction and ring construction databases. He is the author of 50 scientific papers in refereed journals and 6 book chapters on the subject of green chemistry metrics and education. In 2000 he launched the CareerChem website (http://www.careerchem.com/MainFrame.html) which is an in-depth resource for tracking and cataloguing all named things in chemistry and physics, chronicling the development of chemistry through scientific genealogies, and supplying career information to young researchers and students for placement in academic and industrial positions worldwide.

• Aims and Scope. General Comments on Organic Chemistry and Green Chemistry. Problems with Literature Reporting of Synthesis Plans. Problems and Challenges in Synthesis and Green Chemistry. Overview of Green Metrics. Optimization. Named Organic Reaction Database. Example Transformations Illustrating Sacrificial Reagents. Synthesis Strategies. Ring Construction Strategies. Example Highlights from Database. Summary of Overall Trends in Synthesis Database. Compounds with Multiple Plans. Appendix A. Appendix B. Index.