Coordination Chemistry Perspectives – serie
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3 produkter
3 produkter
Inbunden, Engelska, 2025
3 517 kr
Skickas inom 5-8 vardagar
Heavy metals essential to organisms are termed “biometals”. Bio-inorganic chemistry deals with the functions of biometals in vivo at an atomic to molecular level, while cellular regulation of biometals such as absorption and transport has been investigated in cell biology. Although these research fields are independently developed and matured, interdisciplinary information across these fields is required for a comprehensive understanding of the roles of biometals at atomic to molecular, cellular and organism levels.This book focuses on iron (Fe) in cells, since it is the most abundant metal in living system and is involved in a variety of physiological events such as enzymatic reactions as catalysts and signal transduction. Both excess and shortage of iron cause serious diseases such as anaemia, cancer and neuronal degeneration. The cellular systems consisting of many specific proteins strictly control the iron contents through the iron dynamics in cells including absorption, sensing, storage, transport and usage.Resulting from a 5-year project on Integrated Biometal Science in Japan, this book not only documents the latest research but also fills a gap between chemical understanding and our real life, by providing fundamental ideas on genetics, drugs and environmental health.
Inbunden, Engelska, 2025
2 989 kr
Skickas inom 5-8 vardagar
Heavy metals essential to organisms are termed “biometals”. Bio-inorganic chemistry deals with the functions of biometals in vivo at an atomic to molecular level, while cellular regulation of biometals such as absorption and transport has been investigated in cell biology. Although these research fields have independently developed and matured, interdisciplinary information across these fields is required for a comprehensive understanding of the roles of biometals at atomic to molecular, cellular and organism levels.This book highlights the latest progress in zinc biology, from its chemistry to its association with diseases. Zinc is the second most abundant trace metal in living organisms, playing a crucial role in many biological processes. It functions as a catalyst in enzymatic reactions, a structural component in proteins, and a signalling molecule in cellular pathways. Zinc homeostasis is tightly regulated by proteins involved in absorption, storage, transport, and utilization. Disruptions in homeostasis are linked to various diseases.Resulting from a 5-year project on Integrated Biometal Science in Japan, this book not only documents the latest research but also fills a gap between chemical understanding and our real life.
Inbunden, Engelska, 2025
3 517 kr
Skickas inom 5-8 vardagar
Heavy metals essential to organisms are termed “biometals”. Bio-inorganic chemistry deals with the functions of biometals in vivo at an atomic to molecular level, while cellular regulation of biometals such as absorption and transport has been investigated in cell biology. Although these research fields have independently developed and matured, interdisciplinary information across these fields is required for a comprehensive understanding of the roles of biometals at atomic to molecular, cellular and organism levels. Focusing on the biological significance of copper in our bodies, this book considers the maintenance of copper from different perspectives ranging from bio-inspired catalysts and mechanisms of copper proteins to pathological roles in diseases. Both quantity and quality of copper inside and outside the cell are essential for our health. Because of its high redox activity, copper acts as an active site for electron transfer and enzyme reactions in many proteins. Genetic and environmental disorders of copper metabolism are therefore associated with many diseases. In addition, copper-containing proteins are involved in the activation of molecular oxygen and have served as a good model for the development of inorganic copper complexes for industrial applications.Resulting from a 5-year project on Integrated Biometal Science in Japan, this book not only documents the latest research but also fills a gap between chemical understanding and our real life.