Current Status of Modern Therapy – Serie
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The past few years have seen the publication of a large number of articles and not a few books on the subject of relief of intractable pain. New ideas have been put forward on pain mechanisms, new methods of treatment have been reported and improved results c1aimed, and a growing catalogue of complications oftreatment has been recorded. The vast and expanding literature on the subject poses for the reader the dual problems of surveil lance and of assessment. The object of the present book is to provide a critical and constructive review of current writings and ideas on a wide range of aspects of the nature of intractable pain, particularly of present day practice and new ideas on treatment. Each chapter is written by an acknowledged authority and the approach throughout is practical rather than academic. In editing the individual chapters an effort was made to achieve a contemporary approach and to eliminate material which was unduly historicalor retrospective in content. At the same time the individ ual style of the authors was retained as far as possible. For decades chronic pain has been a therapeutic 'no man's land'. For the surgeon pain was an unfortunate complication wh ich not infrequently followed surgery; for the physician it was a distressing symptom in a number of disease syndromes; to the psychiatrist it was one of a number of features in many cases of mental illness.
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Treatment of Medical Problems in the Elderly
Häftad, Engelska, 2014
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Del 4 - Current Status of Modern Therapy
Antibiotics and Chemotherapy
Current Topics
Häftad, Engelska, 2012
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The purpose of this book is to provide reviews of various antibiotic topics which will be of interest to practising clinicians and to microbiologists. It is hoped that enough references have been provided to enable the enthusiast to immerse himself in the source literature. No attempt has been made to cover the whole field, which is well catered for in the numerous works on the subject. Rather, the intention has been to select a number of topics in which there has been a great deal of change in recent years, and to ask an appropriate authority to review the subject. Since I chose the topics, it may be supposed, quite correctly, that I have identified subjects in which I felt myself to require some postgraduate education. The process was something like the well known radio programme in which a castaway is allowed to select a number of gramophone records to take with him to a desert island. I hope that readers will share my interest in the contributions from a number of distinguished contributors to the field of antibiotic chemotherapeutic research. Although I have had the privilege of editing this volume it will be understood that the views expressed by the authors are their own and have not been the subject of editorial review. I am grateful to all the collaborators in this volume, and to the publishers, MTP Press, for their help, and for asking me to undertake the task. R. N.
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In this volume I have attempted to cover the more important aspects of immunosuppressive therapy. In doing this, I have been very fortunate in securing the help of the distinguished authors who have contributed the chapters that follow and I am grateful to them for providing such thorough and up-to-date accounts of their subjects. Immunosuppression can be mediated by many hundreds of agents and it has been difficult to strike a balance between the 'small print' of drug action in animals and the useful ness or otherwise of drugs and other agents for inducing immunosuppression in patients. The first six chapters deal mainly with the experimental aspects of lmmunosuppression and include a full discussion of total lymphoid lrradiation and cyclosporin-A. Both these agents have shown great promise recently as forms of immunosuppression in animals and undoubtedly will come to be used more and more in patients recelvmg transplants of one form or another. The last four chapters are devoted to the use of the more traditional immunosuppressive agents for specific clinical conditions. In her chapter on renal transplantation, Dr McGeown describes in great detail not only the immunosuppressive regime she employs but the general manage ment of transplant patients. The clinical results have been so good in her unit that I felt her account should include these other aspects of treatment since they would seem to be just as important as the immunosuppressive regime she uses.
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During the last few years, there has been growing medical interest in the problem of obesity. Although this may not have resulted in a dramatic breakthrough in our understanding of the condition, at least we are now more aware of our ignorance. Possibly this partly explains the increasing medical concern for, and sympathy in, the management of the obese. In the introductory chapter, John Garrow says that he believes it would be better to treat a few people well than many subjects unsuccessfully. This theme is developed in those chapters which deal with specific forms of therapy including exercise, protein-sparing fasting and bypass surgery, while the chapters on pharmacological agents review our knowledge, and our ignorance, of the mode of action and efficacy of the currently available drugs. Almost in contrast, the chapter on behavioural therapy and group therapy suggests that obesity is a problem which could best be tackled on a community basis. Clearly such an approach is very attractive, and the combination of behavioural therapy and slimming organizations would appear to offer the best prospects of controlling most subjects' weight problems. There will always remain, however, the individual patient in whom there will be a place for the various special techniques now available. It is hoped that this book will contribute to a greater understanding of the various problems faced by the obese, and the regimes that can be offered. J. F. MUNRO xi 1 How to treat and when to treat J. S.
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In the past few years there has been a great upsurge of interest in the problem of essential hypertension. This has been stimulated by several comparatively recent advances, the most important being the demon stration that many if not most of the cOInplications of hypertension can be prevented with adequate and effective medical treatment. Because of the extremely high prevalence of hypertension (roughly one in six or seven adults) effective preventive treatment will have a tremendous im pact on national health and longevity. This new approach to the problem of hypertension differs markedly from the old, which concentrated on a meticulous and expensive search for curable forms ofhypertension representing at most 5% ofthe hyper tensive population. Today, however, we are facing up to a much greater challenge. Now many patients with hypertension, not just a selected frac tion, are possible candidates for treatment. Therapeutic decisions need to be made which will affect the health and well-being of millions of people. This change has been truly revolutionary as, for the first time, it has become possible to influence a leading cardiovascular disorder therapeu tically and prevent its complications. This volume presents the current thought ofleading experts in the new movement in hypertension. Their purpose is to supply the most recent in formation in the field in such a way that it can be applied by the physi cian in practice. In fact, this book is intended as a guide to the new management ofhypertension.