Annual Reports in Medicinal Chemistry

New Approaches in Conjugate Drug Design: Part 1, published as Volume 67 of the serial Annual Reports in Medicinal Chemistry, provides a comprehensive overview of current strategies in the design and application of drug conjugates. Chapters cover small molecule drug conjugates, antibody-to-small molecule carrier approaches, antibiotic-derived and terpene-derived antimicrobial conjugates, aptamer-RNA conjugates, and phenolic and metal natural product conjugates. Applications span anticancer, antiviral, antifungal, and theranostic therapies, including photoactivatable therapy and emerging approaches in quantum oncology. The volume serves as a reference on design principles, therapeutic applications, and clinical progress in conjugate-based drug discovery.

• Surveys design principles, therapeutic applications, and clinical progress of small molecule drug conjugates
• Covers diverse conjugate classes, including antibiotic-derived, terpene-derived, aptamer-RNA, phenolic, and metal natural product conjugates
• Addresses applications across anticancer, antiviral, antifungal, and antimicrobial drug discovery
• Includes emerging approaches such as theranostic conjugates, photoactivatable therapy, and quantum oncology
• Features contributions from an international group of expert authors