Abdul Aziz Nather - Böcker

Advances in Tissue Banking is the first authoritative publication to encompass this interdisciplinary field, which is now providing hundreds of thousands of tissue grafts for transplant surgery every year worldwide (400,000 grafts in the USA alone annually). There is no text book which can be consulted about the subject, since the field has moved so rapidly over the past few years. The scientific and medical publications are scattered throughout specialised literature and are not readily accessible to all the diverse practitioners.This book, volume 1 of the new series, is written by experts on the subject. It is designed to fill the gap and provide a vehicle of communication for those participating in various aspects of the subject. Regulators are still in the process of coming to grips with the requirements to ensure safety and find a suitable definition within the legislative system for a “transplant tissue”. The various transplant donation systems in various countries differ. Allografts are used extensively in orthopaedic surgery, burns and wound healing. Heart valve banking has now established itself. Central to the subject is the prevention of the transmission of infection, with great emphasis being placed on the screening of donors, preservation and sterilisation of the tissues using the best and safest procedures.Nobody connected with regulating, producing, or using tissues can afford to be without the concentrated information so readily provided in this book, which is not available elsewhere. It will also be of great value to scientists and doctors who wish to learn about the subject and to introduce it into general scientific and medical education.

This volume of tissue banking is the second of a series extending the interdisciplinary field. All of the authors of this book have been major contributors of scientific and medical publications in their respective specialities. There are articles covering blood transfusion; bone marrow and stem cell transplantation; immunology and the role of immunology in musculoskeletal transplantation, various aspects of cryopreservation of organs, cartilage and tendons; organ perfusion preservation; the history and long term follow-up of osteochondral allografts, both frozen and fresh; neurosurgical applications; cardiovascular applications; the use of skin and newer biological membranes for wound coverage.The book is of particular importance, in that it has been written in memory of Kenneth W Sell, MD, PhD, a pioneer and promulgator of tissue banking and transplantation. Many of the physicians, surgeons and scientists who trained under his leadership have gone on to distinguish themselves in the various aspects of transplantation. Many of them have contributed to this book, exemplifying the diversity of Dr Sell's contributions to tissue banking and transplantation.

This important book provides new information about the inter-disciplinary field of tissue banking and related clinical applications, and complements the previous two volumes. It gives comprehensive coverage of the regulatory framework of the subject, as well as production and sterilisation of tissue allografts (bone, skin and new substitutes). The use of tissue allografts in orthopaedic and replacement surgery for the treatment of burns, etc. is described.

This series has now established itself as the leading publication on the multi-disciplinary subject of tissue banking. The high quality of the contributors and the broad coverage of the subject have continued in Volume 4. The material given in this volume is not presented anywhere else as systematically or as authoritatively.The essential feature in establishing confidence in the quality and safety of allografts is the manufacturing quality system utilised. This volume describes the most recent approach to good manufacturing control.Throughout the world, the old cottage approach to tissue banking is being abandoned, mainly due to the insistence by regulatory authorities that the procedures should be standardised and rigorous infection control applied. The experience in a number of countries is described in this volume, giving the reader quick access to developments in Argentina, Finland, Indonesia, Scotland and France. These represent a geographical and cultural spread of the developments.A balance needs to be struck between the use of allografts and of bone substitutes, depending on the clinical condition and the availability of grafts in a particular situation. The subject areas — such as mandibular reconstruction, spinal surgery, surgery and reconstruction of bone tumours and acetabular revision — covered in this volume demonstrate the universality of this technique. The use of allografts for the repair of knee ligaments has been and remains a controversial subject. The contributions on this subject will surely be an important and positive addition to this debate.

This important book contains in one volume various subjects, including anatomy, physiology, microbiology, radiation sciences, biology of healing of allografts, biomechanics of allografts and transplantation immunology. It is intended for easy and comprehensive use by practitioners in the field of tissue banking and tissue transplantation. It can also serve as a textbook for a course in tissue banking.

This book is written as a comprehensive guide for residents and young orthopaedic surgeons embarking on research, especially for those doing so for the very first time. It is specially designed to cater to the needs of trainees in the region preparing their theses for masters or fellowship degrees in orthopaedic surgery.It provides a detailed insight on the importance of strategic planning, organisational ability, resourcefulness, innovativeness and creativity to produce good research. Even more crucial is the necessity to have dedication, perseverance and strong commitment to pursue research. Infra-structural, technical, manpower and funding support are equally important. It describes how the investigator must plan his research well and outlines the strategies he could adopt to write an application for the much needed research grant.The book presents the basic methodology for animal experimentation research, histological techniques, biomechanical testing, microvascular surgery and cell culture techniques including tissue engineering. Also featured are the latest developments in the various clinical sub-specialties in orthopaedics & reconstructive surgery: spine, hip, knee, paediatrics, hand and oncology, highlighting research opportunities in the various clinical disciplines that could be explored. It ends with a guide on how to write the finished product — an article for a journal or a thesis/dissertation for a post-graduate examination. The final chapter outlines how total objective evaluation of a young researcher's output should be conducted.

This book is written as a comprehensive and practical guide for General Practitioners who often manage patients with diabetic foot complications. Topics covered include Types of Diabetic Foot Complications, Basic Science involved, Examining a Diabetic Foot, Doing Investigations and Treating a Diabetic Foot, Endocrine Control, Nutritional Support, Choice of Wound Dressing and Choice of the appropriate Antibiotic. An important chapter, especially useful to the GPs is a practical guide on when to treat the patients in their clinics and when to send them to hospitals for management by Diabetic Foot Specialists. A special emphasis has also been given to guide GPs how to educate their patients on Care of Diabetes itself, Care of the Foot and Choice of Footwear. In addition, this Companion Book to GPs will also be useful to Nurses and Podiatrists who also provide care to Diabetic Foot patients. For the latter, a Supplement has been added. Relevant topics include Team Approach, Nursing a Diabetic Foot, Nutrition, Wound Dressings, Negative Pressure Wound Therapy, Maggot Debridement Therapy, Off-loading & Shoes, Hyperbaric Oxygen Therapy, Charcot Joint Disease and Rehabilitation.

This book provides the latest updates on the major challenges of bridging large bone defects, where options range from autografts, “tissue engineered bone”, biomaterials (hydroxyapatite, polycaprolactone and third generation biomaterials) to prostheses. Emphasis has been made on bone tissue engineering, the current state-of-the-art in this field, problems encountered with cell culture technology, scaffolds and bone growth factors (including genomics) and the use of gene therapy for the application of bone growth factors. Attention has also been given to the use of bone autografts. It also covers the use of biomaterials and prostheses as other options for reconstruction. Clinical applications, in addition to the basic science, are also included throughout the discussions.

This important book discusses the need for gamma irradiation in the processing of tissue allografts. With particular emphasis on tissue banking in the Asia-Pacific region, it covers a wide range of issues in tissue banking, including the basic science of radiation, quality control of the irradiation process, and clinical applications of irradiated bone grafts and amnions.A compulsory textbook for the well-regarded Singapore-based IAEA/NUS Diploma Course in Tissue Banking, it is also a useful guide for tissue bankers in establishing quality systems in their banks. Whether they be tissue banking students, tissue graft producers, radiation scientists, or transplantation surgeons, readers of this book will discover the latest developments in this exciting interdisciplinary field.

This pioneering textbook is the first one ever on diabetic foot problems. With contributions from a multidisciplinary panel of experts, it presents a comprehensive curriculum on the topic. This includes global and socio-economic aspects of diabetes; a team approach; basic science of the foot (anatomy and biomechanics); clinical assessment and classification systems for diabetic foot problems; endocrine aspects; diabetic foot infections (clinical presentation and management); amputations in diabetic foot surgery (predictive factors, major and distal amputations, rehabilitation and phantom pain management); care of diabetic wounds (including the role of the latest technologically advanced dressings, vacuum dressings, anodyne therapy, ultrasonic debridement and extracorporeal shockwave therapy); and diabetic footcare and diabetic footwear.

This pioneering textbook is the first one ever on diabetic foot problems. With contributions from a multidisciplinary panel of experts, it presents a comprehensive curriculum on the topic. This includes global and socio-economic aspects of diabetes; a team approach; basic science of the foot (anatomy and biomechanics); clinical assessment and classification systems for diabetic foot problems; endocrine aspects; diabetic foot infections (clinical presentation and management); amputations in diabetic foot surgery (predictive factors, major and distal amputations, rehabilitation and phantom pain management); care of diabetic wounds (including the role of the latest technologically advanced dressings, vacuum dressings, anodyne therapy, ultrasonic debridement and extracorporeal shockwave therapy); and diabetic footcare and diabetic footwear.

This is the first textbook on surgery for Diabetic Foot in the world. It is written as a practical surgery manual for residents and young surgeons performing surgical procedures for patients with diabetic foot problems. Such a guide will be useful not only to residents and surgeons in Singapore but also to our neighbouring countries including, Malaysia, Indonesia, Hong Kong, India, Sri Lanka etc. Each surgical procedure is written in a systematic fashion covering indications, pre-operative preparation, anaesthesia, patient positioning, operative technique (in step by step fashion and illustrations) and post-operative care.The scope covers all aspects of surgery for diabetic foot from surgical debridement, split skin grafting, surgery for osteomyelitis, minor amputations including ray, transmetatarsal, Lisfranc, Chopart and Modified Pirogoff amputation to major amputations such as below knee, through knee and above knee amputation. It also includes assessment for revascularisation and revascularisation procedures.This book will serve as a useful practical guide for training surgical residents and for surgeons aspiring to do diabetic foot surgery.

This book is a comprehensive guide for all tissue bank operators to screen, procure and process amniotic membrane for clinical application.The amnion comes close to being the ideal biological membrane or dressing — readily available, inexpensive to procure and process. Its basic science is discussed in detail — anatomy, biological and biomechanical properties.It can be procured from the placenta in normal vaginal deliveries and from Caesarean Sections. Processing is by freeze-drying or by air-drying process with sterilisation using gamma irradiation.The product has low antigenicity, has anti-microbial properties with ability to enhance epithelisation with marked relief of pain. It is useful as a dressing for wounds — flap wounds, burn wounds, injury wounds, diabetic ulcers, leprous ulcers and post-surgery wounds and post-radiation wounds. It is also used as a biological scaffold for cells in tissue engineering. Its ophthalmic applications include treatment of corneal ulcers and conjunctival tumours. Oral uses include gingiva depigmentation and periodontal regeneration.

This book is written as a comprehensive guide for all tissue bank operators to procure and process bone and soft tissue allografts of highest quality standards for safe tissue transplantation practice in patients who require musculoskeletal tissue allograft transplantation. This comprehensive guide includes donor selection criteria, aseptic procurement techniques, laboratory testing and processing of grafts by deep freezing or freeze drying. It also includes sterilization of tissue grafts using gamma irradiation. Quality controls of tissue grafts are discussed in depth. The clinical transplantation of bone and soft tissue allografts is also discussed, with special consideration given to potential complications. Principles of sterile technique in the operating theater are described. The book also incorporates the basic sciences of tissue banking including anatomy, biomechanics, microbiology and immunology. It also covers radiation science so that the reader can better understand radiation sterilization of tissue grafts. Included in the book is a guide for public awareness programmes, radiation code of practice and general standards for tissue banking as recommended by the International Atomic Energy Agency.

This book provides a comprehensive guide for all healthcare professionals managing diabetic foot problems including general practitioners, nurses, podiatrists, orthopaedic surgeons, vascular surgeons and endocrinologists. It is also written in an easy to read fashion so that patients and caregivers will also find it useful.It covers a wide range of topics on the Diabetic Foot starting with an Introductory Section on “Overview of Diabetes”. Topics include ‘What is Diabetes?’, ‘Complications of Diabetes’ and ‘Management of Diabetes’. The section on “Basic Science of Diabetic Foot” covers Anatomy, Biomechanics and Pathogenesis: the Diabetes Foot Triad of Neuropathy, Vasculopathy and Immunopathy. Other Sections include Classification, Clinical Presentation and Treatment.A highlight of the book is the large “Guide to Operative Surgery” section. This section covers Major Amputations, Minor Amputation and other Diabetic Foot Surgeries. The latter details Surgical Debridement and Split Skin Grafting — two of the commonest operations performed. This operative manual is also useful to residents and registrars.The section on Wound Care has also been carefully assembled to meet the needs of nurses, podiatrists and general practitioners, performing day to day dressing of diabetic wounds. It focuses on the use of New Generation Dressings including Silver and Iodine Dressings and Advances in Wound Healing. Patients and Care-givers will also find this useful.The last section “A Patient's Guide” is especially written to benefit patients and care-givers. It includes ‘Care of Diabetes’, ‘Care of the Foot’, ‘Choosing your own Footwear’, ‘Doing your own Dressing’ and ‘Rehabilitating your Below Knee Amputation’.Finally, the Appendix includes details of the formation of NUH Diabetic Foot Team, Asia Pacific Association of Diabetic Limb Problems and the ASEAN Plus Expert Group Forum on the Management of Diabetic Foot Wounds.

This book is a practical guide for residents and young researchers who are planning to embark on research. It details the significant planning one must first do including choosing a suitable experienced clinician as a supervisor, sourcing for a "winning idea" with significant clinical impact, performing a proper review of literature, defining clearly the objectives to be set and adopting the appropriate methodology. Statistical evaluation must be done from the start of the research to define adequate sample size and also for evaluation of the results. It also advises how one should draw upon relevant and appropriate conclusions from the results obtained.The ethics of research is also discussed. An all-important factor in research is the procurement of research grants. Readers are guided how to write a proper research proposal to secure these much needed grants.Many research papers end up as presentations only in local or international conferences. An important additional objective of this book is to guide young researchers how to write their finished product — as a publication in an important international, refereed journal or as a thesis. Chapters have been specially written with tips for scientific writing, selecting the right journal, writing for an original article for a journal, a review article, a case report as well as for a thesis. Tips are also written on what reviewers of a journal look for in an article as well as what examiners look for in a thesis.

This book is a practical guide for residents and young researchers who are planning to embark on research. It details the significant planning one must first do including choosing a suitable experienced clinician as a supervisor, sourcing for a "winning idea" with significant clinical impact, performing a proper review of literature, defining clearly the objectives to be set and adopting the appropriate methodology. Statistical evaluation must be done from the start of the research to define adequate sample size and also for evaluation of the results. It also advises how one should draw upon relevant and appropriate conclusions from the results obtained.The ethics of research is also discussed. An all-important factor in research is the procurement of research grants. Readers are guided how to write a proper research proposal to secure these much needed grants.Many research papers end up as presentations only in local or international conferences. An important additional objective of this book is to guide young researchers how to write their finished product — as a publication in an important international, refereed journal or as a thesis. Chapters have been specially written with tips for scientific writing, selecting the right journal, writing for an original article for a journal, a review article, a case report as well as for a thesis. Tips are also written on what reviewers of a journal look for in an article as well as what examiners look for in a thesis.