Andreas Plaitakis – författare
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2 produkter
2 produkter
Del 2 - Foundations of Neurology
Cerebellar Degenerations: Clinical Neurobiology
Inbunden, Engelska, 1992
4 434 kr
Skickas inom 10-15 vardagar
This book encompasses basic and clinical reports on the cerebellum and its primary atrophic disorders, the cerebellar degenerations. Rapid progress has been made in understanding the organization and function of the cerebellum at the neuronal, synaptic and molecular level. Of particular importance has been the identification of the chemical transmitters utilized by the cerebellar cellular systems. More then any other brain region, the cerebellum utilizes amino acids as its main excitatory and inhibitory neurotrasmitters. Excitatory amino acid transmiters, in addition to serving neuronal communication, may also mediate trophic and toxic effects and, as such, they may play a role in neurodegenerative processes. This volume should be useful to clinicians who care for patients with cerebellar disorders as well as to the basic and the clinical investigators whose work concerns the cerebellum. Knowledge of advances occurring in basic sciences will help the clinical investigator to develop new approaches and therapeutic strategies for these presently intractable human disorders.Also the basic investigator will benefit from the study of human disorders by identifying new research leads provided by these intractable - yet fascinating - afflictions.
Häftad, Engelska, 2012
2 845 kr
Skickas inom 5-8 vardagar
This book encompasses basic and clinical reports on the cerebellum and its primary atrophic disorders, the cerebellar degenerations. Rapid progress has been made in undestanding the organization and function of the cerebellum at the neuronal, synaptic, and molecular level. Of particular importance has been the identification of the chemical transmitters utilized by the cer ebellar cellular systems. More than any other brain region, the cerebellum utilizes amino acids as its main excitatory and inhibitory neurotransmitters. Excitatory amino acid transmitters, in addition to serving neuronal com munication, may also mediate trophic and toxic effects, and as such, they may playa role in neurodegenerative processes. The cerebellar degenerations were among the first human disorders with primary system atrophy to be studied clinically and pathologically. This field of clinical cerebellar sciences, no longer confined to the previously known descriptive level, is now advancing rapidly, propelled by rapid advances in neuroimaging, immunology, and molecular biology. The advent of CT, MRI, and PET has in recent years permitted the study of central nervous system alterations in living patients, thus contributing substantially to the accuracy of the diagnosis and the classification of these disorders. The nosology of cerebellar degenerations, which has been the subject of much debate for over a century, is presently a dynamic field, with new entities being recognized and old "classic ataxias" being redefined in the light of new genetic evidence.