Bernhard Maisch – författare

The special issue of "Molecular and Cellular Biochemistry" focuses on "Control of Gene Expression by Catecholamines and the Renin-Angiotensin System" in health and disease. In the 1990s great progress was made in the understanding of catecholamine- and angiotensin II-modulated gene expression. There is also increasing evidence that catecholamine and angiotensin II induced cellular injury arises not solely from classical pathways, but also from a perturbed gene expression. Taking into account that catecholamines and angiotensin II are vital for a balanced gene expression of many cells, the intriguing possibility arises that various disease are initiated or aggravated by such an imbalance. Catecholamine and angiotensin II influences can be in excess arising from, for example, hypercaloric food intake or psychosocial stress. During early progression of heart failure, sympathetic activity and angiotensin II influences also become increased. Due to beta-adrenergic receptor downregulation, depressed catecholamine influences are expected in the final stage of heart failure.An imbalanced influence of catecholamines and angiotensin II on gene expression leads to disordered molecular structures of the cell and an impaired cell function. This focused issue is organized into chapters concentrating on catecholamines, angiotensin II, and the interaction between catecholamines and angiotensin II. Basic biochemical processes are covered in detail and the potential of these pathways for explaining chronic diseases associated with excess catecholamine and angiotensin II influences should become apparent. It is hoped that this focused issue will trigger novel research into the development of drugs that are targeted at diseases characterized by an imbalanced gene expression involving catecholamines and angiotensin II.

The special issue of Molecular and Cellular Biochemistry focuses on `Control of Gene Expression by Catecholamines and the Renin-Angiotensin System' in health and disease. This focused issue is organized into chapters concentrating on catecholamines, angiotensin II, and the interaction between catecholamines and angiotensin II.

The special issue of Molecular and Cellular Biochemistry focuses on `Control of Gene Expression by Catecholamines and the Renin-Angiotensin System'' in health and disease. In recent years, great progress has been made in the understanding of catecholamine and angiotensin II modulated gene expression. There is also increasing evidence that catecholamine and angiotensin II induced cellular injury not solely arises from classical pathways but also from a perturbed gene expression. Taking into account that catecholamines and angiotensin II are vital for a balanced gene expression of many cells, the intriguing possibility arises that various disease are initiated or aggravated by such an imbalance. Catecholamine and angiotensin II influences can be in excess arising from, for example, hypercaloric food intake or psychosocial stress. During early progression of heart failure, sympathetic activity and angiotensin II influences also become increased. Due to beta-adrenergic receptor downregulation, depressed catecholamine influences are expected in the final stage of heart failure. An imbalanced influence of catecholamines and angiotensin II on gene expression leads to disordered molecular structures of the cell and an impaired cell function. This focused issue is organized into chapters concentrating on catecholamines, angiotensin II, and the interaction between catecholamines and angiotensin II. Basic biochemical processes are covered in detail and the potential of these pathways for explaining chronic diseases associated with excess catecholamine and angiotensin II influences should become apparent. It is hoped that this focussed issue triggers novel research into the development of drugs that are targeted at diseases characterized by an imbalanced gene expression involving catecholamines and angiotensin II.

Interventional Pericardiology gives a unique and comprehensive view on an often neglected but clinically very important part of cardiovascular disease: The pericardium and the adjacent myocardium or epicardium. The authors of this up-to-date compendium on pericardial disease etiology, diagnostics and treatment, Professors Bernhard Maisch (Marburg), Arsen Ristic (Belgrade), Petar Seferovic (Belgrade) and Teresa Tsang (Rochester) focus on recent advances to the new window that has been opened to the heart by flexible and video-assisted pericardioscopy, modern biochemical, immunohistological and molecular tools for the analysis of epicardial and pericardial biopsies, which have been acquired safely under pericardioscopic control by the interventional pericardiologist. Their book adds brand-new information to the recent and so far only guidelines world-wide by the European Society of Cardiology on the management of pericardial diseases. This task-force has been chaired by the lead author B. Maisch. Accordingly “Interventional Pericardiology” belongs in every medical library and on the desk of every cardiologist, cardiological interventionalist, and trainee with an interest in pericardial diseases.