David Latchman – författare
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3 produkter
3 produkter
Inbunden, Engelska, 1998
3 350 kr
Skickas inom 10-15 vardagar
The stress proteins or heat shock proteins were originally identified on the basis of their enhanced synthesis following stress. It is now clear, however, that they also play a key role in stressed cells and in specific human diseases. This book provides a comprehensive account of these proteins, emphasizing the functions of the different stress proteins in unstressed and stressed cells of different types, their regulation by stressful and non-stressful stimuli and their roles in a range of human diseases.
Inbunden, Engelska, 1999
1 928 kr
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Since the publication of the first edition, a wide range of new methodologies have been developed to facilitate studies on both isolated parts of the genome and the genome as a whole. This edition has been updated to provide a comprehensive guide to the methods available to characterize the function and activity of an individual transcription factor. All the original chapters have been fully updated or rewritten and additional chapters cover the use of in vitro transcription assays, analysis of chromatin structure, use of the genomic binding site assay and analysis of transcription factor modifications. As with the previous edition, the book starts with a series of chapters concerned with characterizing the proteins binding to a specific DNA sequence and then a chapter on more detailed characterization of the protein itself. The next two chapters describe the isolation of cDNA clones encoding a transcription factor using oligonucleotides predicted from protein sequence and screening of a cDNA expression library.
Häftad, Engelska, 2010
719 kr
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Gene Control offers a current description of how gene expression is controlled in eukaryotes, reviewing and summarizing the extensive primary literature into an easily accessible format. Gene Control is a comprehensively restructured and expanded edition of Latchman’s Gene Regulation: A Eukaryotic Perspective, Fifth Edition. The first part of the book deals with the fundamental processes of gene control at the levels of chromatin structure, transcription, and post-transcriptional processes. Three pairs of chapters deal with each of these aspects, first describing the basic process itself, followed by the manner in which it is involved in controlling gene expression. The second part of the book deals with the role of gene control in specific biological processes. Certain chapters deal with the importance of gene control in cellular signaling processes and for normal development of the embryo. Another chapter discusses the key roles played by gene-regulatory processes in the specification of differentiated cell types such as muscle cells and neurons. The final chapters discuss the consequences of errors in gene control; the relationship between gene misregulation and human diseases, especially cancer; and potential therapies designed specifically to target particular levels of gene control.Gene Control will be of value to students in biological sciences, as well as to scientists and clinicians interested in how genes are regulated in health and disease.