Friedhelm Raue – författare
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9 produkter
9 produkter
Del 223 - Recent Results in Cancer Research
Medullary Thyroid Carcinoma
Biology, management, and treatment of sporadic and hereditary MTC
Inbunden, Engelska, 2025
1 570 kr
Skickas inom 10-15 vardagar
After 10 years, this second edition is extensively rewritten and updated and provides a source of information concerning all aspects of medullary thyroid carcinoma, including comprehensive actual references for interested scientists.Medullary thyroid carcinoma (MTC) is a rare unique tumor which differs from other thyroid tumors by originating from the neuroendocrine C-cell, secreting the specific tumor marker calcitonin. MTC is associated in about 25% of cases with multiple endocrine neoplasia type 2, an autosomal dominant familial disorder causing tumors within various endocrine glands. The molecular genetics of tumor development is clarified: hereditary as well as sporadic MTC are linked to mutations in the RET proto- oncogene coding for a tyrosine kinase. These RET mutations serve as a genetic marker for hereditary MTC and allow for prophylactic thyroidectomy in gene carriers. The RET-tyrosine kinase is also a new therapeutic target using selective tyrosine kinase inhibitors improving the outcome of advanced metastasized MTC. This book will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.
E-bok
Engelska, 20251 879 kr
Läs direkt efter köp
After 10 years, this second edition is extensively rewritten and updated and provides a source of information concerning all aspects of medullary thyroid carcinoma, including comprehensive actual references for interested scientists.
Medullary thyroid carcinoma (MTC) is a rare unique tumor which differs from other thyroid tumors by originating from the neuroendocrine C-cell, secreting the specific tumor marker calcitonin. MTC is associated in about 25% of cases with multiple endocrine neoplasia type 2, an autosomal dominant familial disorder causing tumors within various endocrine glands. The molecular genetics of tumor development is clarified: hereditary as well as sporadic MTC are linked to mutations in the RET proto- oncogene coding for a tyrosine kinase. These RET mutations serve as a genetic marker for hereditary MTC and allow for prophylactic thyroidectomy in gene carriers. The RET-tyrosine kinase is also a new therapeutic target using selective tyrosine kinase inhibitors improving the outcome of advanced metastasized MTC.
This book will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.
Del 223 - Recent Results in Cancer Research
Medullary Thyroid Carcinoma
Biology, management, and treatment of sporadic and hereditary MTC
Häftad, Engelska, 2026
1 123 kr
Skickas inom 10-15 vardagar
After 10 years, this second edition is extensively rewritten and updated and provides a source of information concerning all aspects of medullary thyroid carcinoma, including comprehensive actual references for interested scientists.Medullary thyroid carcinoma (MTC) is a rare unique tumor which differs from other thyroid tumors by originating from the neuroendocrine C-cell, secreting the specific tumor marker calcitonin. MTC is associated in about 25% of cases with multiple endocrine neoplasia type 2, an autosomal dominant familial disorder causing tumors within various endocrine glands. The molecular genetics of tumor development is clarified: hereditary as well as sporadic MTC are linked to mutations in the RET proto- oncogene coding for a tyrosine kinase. These RET mutations serve as a genetic marker for hereditary MTC and allow for prophylactic thyroidectomy in gene carriers. The RET-tyrosine kinase is also a new therapeutic target using selective tyrosine kinase inhibitors improving the outcome of advanced metastasized MTC. This book will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.
E-bok
PDF, Engelska, 20151 698 kr
Läs direkt efter köp
This book offers a comprehensive overview of medullary thyroid carcinoma, both in the more common sporadic form and in the familial form, multiple endocrine neoplasia (MEN) types 2A and 2B. The coverage includes, but is not limited to, molecular biology and genetics, pathology, clinical presentation, imaging techniques, surgical treatment, and follow-up. The role of calcitonin as a highly sensitive and specific tumor marker for the screening, diagnosis, and follow-up of MTC and metastatic disease is described, and the significance of other tumor markers is also considered. With regard to treatment, the use of thyroidectomy is fully discussed, including in children carrying the mutations in the RET proto-oncogene considered causative for MEN 2. Additionally, the value of tyrosine kinase inhibitors as the most effective treatment modality in patients with a large tumor burden or rapid tumor growth, or both, is explained. Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2 will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.
Del 204 - Recent Results in Cancer Research
Medullary Thyroid Carcinoma
Biology – Management – Treatment
Häftad, Engelska, 2016
1 346 kr
Skickas inom 10-15 vardagar
This book offers a comprehensive overview of medullary thyroid carcinoma, both in the more common sporadic form and in the familial form, multiple endocrine neoplasia (MEN) types 2A and 2B. The coverage includes, but is not limited to, molecular biology and genetics, pathology, clinical presentation, imaging techniques, surgical treatment, and follow-up. The role of calcitonin as a highly sensitive and specific tumor marker for the screening, diagnosis, and follow-up of MTC and metastatic disease is described, and the significance of other tumor markers is also considered. With regard to treatment, the use of thyroidectomy is fully discussed, including in children carrying the mutations in the RET proto-oncogene considered causative for MEN 2. Additionally, the value of tyrosine kinase inhibitors as the most effective treatment modality in patients with a large tumor burden or rapid tumor growth, or both, is explained. Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2 will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.
E-bok
PDF, Engelska, 20121 408 kr
Läs direkt efter köp
Medullary Thyroid Carcinoma is a rare thyroid tumororiginating from neural crest cells, the C-cell that impliesseveral special features, secretion of differentneuroendocrine markers, association with other endocrinetumors and familial appearance. The familial variant ofmedullary thyroid carcinoma allows an early detection bybiochemical and genetic testing. At that stage acceptablesurgical treatment will cure the patient. The sporadic formof medullary thyroid carcinoma will be diagnosed in aprogressive stage, but adequate surgical procedure can curethese patients too. Long term survival depends on stage,age, sex, and variant of the disease and seems to be as goodas in other differentiated thyroid cancers.
Del 125 - Recent Results in Cancer Research
Medullary Thyroid Carcinoma
Häftad, Engelska, 2011
1 123 kr
Skickas inom 10-15 vardagar
Medullary Thyroid Carcinoma is a rare thyroid tumororiginating from neural crest cells, the C-cell that impliesseveral special features, secretion of differentneuroendocrine markers, association with other endocrinetumors and familial appearance. The familial variant ofmedullary thyroid carcinoma allows an early detection bybiochemical and genetic testing. At that stage acceptablesurgical treatment will cure the patient. The sporadic formof medullary thyroid carcinoma will be diagnosed in aprogressive stage, but adequate surgical procedure can curethese patients too. Long term survival depends on stage,age, sex, and variant of the disease and seems to be as goodas in other differentiated thyroid cancers.
E-bok
PDF, Engelska, 20121 408 kr
Läs direkt efter köp
Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer. The pathophysiological, epidemiological and clinical aspects of hypercalcemia of malignancy are presented in this issue, with a focus on the recently discovered humoral factor responsible for the development of hypercalcemia. With a better understanding of the pathophysiology of this condition and the development of new potent drugs, capable of inhibiting bone resorption, especially bisphosphonates, the clinician will be more successful in correcting hypercalcemia in the great majority of patients.
Del 137 - Recent Results in Cancer Research
Hypercalcemia of Malignancy
Häftad, Engelska, 2012
1 123 kr
Skickas inom 10-15 vardagar
Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer. The pathophysiological, epidemiological and clinical aspects of hypercalcemia of malignancy are presented in this issue, with a focus on the recently discovered humoral factor responsible for the development of hypercalcemia. With a better understanding of the pathophysiology of this condition and the development of new potent drugs, capable of inhibiting bone resorption, especially bisphosphonates, the clinician will be more successful in correcting hypercalcemia in the great majority of patients.