Habib Zaidi – författare

This issue of PET Clinics focuses on PET/MRI: Advances in Instrumentation and Quantitative Procedures. Articles will include: Advances in clinical PET/MRI instrumentation; Magnetic resonance imaging-guided attenuation correction of positron emission tomography data in PET/MRI; Magnetic resonance imaging-guided partial volume correction of positron emission tomography data in PET/MRI; Magnetic resonance imaging-guided derivation of the input function for PET kinetic modeling; Innovations in small-animal PET/MRI instrumentation; Dual-modal PET/MRI molecular imaging probes; Magnetic resonance imaging-guided motion compensation of positron emission tomography data in PET/MRI; Attenuation correction for MR coils in combined PET/MR imaging; and more!

This book provides a review of the history and technologies in the developmentof computational small animal models, with a focus on their application inpreclinical imaging, radiation therapy and dosimetry calculations. It providesan overview of model design of computational models, identification ofanatomical data, the tools used for solving problems and animal modelapplication in preclinical research.

This book covers the applications of Monte Carlo (MC) calculations in therapeutic nuclear medicine from basic principles, to computer implementations of software packages and their applications in radiation dosimetry and treatment planning in targeted radionuclide therapy. The different chapters describe the fundamental concepts of nuclear and hybrid imaging instrumentation and quantitative imaging, internal radiation dosimetry and radiobiology aspects of targeted radionuclide therapy, then discuss the various components and steps required for implementing a dose calculation and treatment planning methodology in targeted radionuclide therapy. Some computer programs are described and illustrated with some useful features and clinical applications. The book is suitable for Scientists working in academic or industrial environments focusing on translational research and therapeutic nuclear medicine and radiology.

Key Features:

This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development.

In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology andpathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.