Keshav K. Singh – författare

Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases all 37 mitochondrial genes and their role in immunity. It describes mitochondrial genetics, organization of mitochondrial genes, and their role in immunity against various disease states in animal models. This title also discusses the role of nuclear genes involved in mitochondrial function, as well as numtogenesis and its role in immune function. It provides a holistic introduction to the study of mitochondrial genomics, or mitogenomics. Co-authored by two experts in mitochondrial determinants of health, early chapters describe the structural organization of mitochondria and mitochondrial genetics using different animal models. Central chapters discuss the role of mitogenomics in metabolic, viral, bacterial, and parasitic diseases, fungal infestations, neurodegenerative disorders, and cancer. The book concludes with the prospects of studying mitochondrial genes using next generation sequencing and the various methodologies for correction of genetic defects in mitochondria. Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases offers a strong foundation for academic researchers, industry scientists, and students interested in disease resistance, immunology, and mitogenomics.Introduces mitochondrial genetics and function using animal modelsDiscusses the role of mitogenomics in various disease statesConsiders the implication of whole mitochondrial genome sequencing in animalsExplores mitochondrial replacement theory and gene editing

Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.