M. F. Greaves – författare

This new se ries is concerned with intercellular communication and recognition. It is now widely appreciated that these processes playa crucial role in virtually all biological systems and functions. These encompass fertilisation, embryonic development, infectious interactions, the activity of the nervous system, the regulation of growth and develop­ ment by hormones and the immune response to foreign or 'non-self antigens. Historically as described in the first review in this volume, the general concept of cell-associated receptors as the molecular entity primarily responsible for the specificity of signal recognition arose independently in the fields of immunology, pharmacology and developmental biology. From an early stage the analogy between cellular recognition and the discriminatory activity of antibodies and enzymes was emphasised. A vital conceptual advance, expressed most c1early by Linus Pauling and Paul Weiss, was the idea that non-covalent molecular interactions (of proteins in particular) were responsible forbiological specificity in in general. In the last decade several major advances have led to a new level of understanding of the molecular basis of cellular recognition. In several systems (in particular with neurotransmitters, hormones and antigens) it is possible to direct1y demonstrate the existence of receptors - associated in each case with the cell surface. These studies have been paralleled by equally important insights into the general structure and organisation of cell membranes and the possible ways in which signals arriving from the 'outside' can be transduced across the cell surface membrane to induce or regulate the cell's programmed responses.

Epidemiology of Leukaemia and Lymphoma contains the proceedings of the Leukaemia Research Fund International Workshop held in Oxford, UK, on September 25-27, 1984. Contributors explore the epidemiology of leukemia and lymphoma based on the results of a pilot study that investigated whether careful subdivision of acute lymphoblastic leukemia (ALL) using a standardized panel of monoclonal antibodies would reveal interesting associations between subtypes and particular geographic regions or ethnic groups within regions. This book is comprised of 31 chapters divided into four sections and begins with a discussion on epidemiological approaches to hematological malignancy, paying particular attention to international data collection and interpretation; clusters and associations in cancer epidemiology; and childhood leukemia in Great Britain and the Netherlands. The next section explores the causes of human leukemia and lymphoma as well as the epidemiology of leukemia and lymphoma subtypes in various regions of the world such as Africa, Asia, United States, and Mediterranean region. The final section focuses on practical problems in standardized immunophenotyping of leukemias and lymphomas; immuno-alkaline phosphatase labeling of hematological samples; and detection of surface membrane antigens by a rosette assay using antibody coupled red cells. This monograph will be of value to clinicians and medical practitioners interested in the epidemiology of leukemia and lymphoma.

This new se ries is concerned with intercellular communication and recognition. It is now widely appreciated that these processes playa crucial role in virtually all biological systems and functions. These encompass fertilisation, embryonic development, infectious interactions, the activity of the nervous system, the regulation of growth and develop­ ment by hormones and the immune response to foreign or ''non-self antigens. Historically as described in the first review in this volume, the general concept of cell-associated receptors as the molecular entity primarily responsible for the specificity of signal recognition arose independently in the fields of immunology, pharmacology and developmental biology. From an early stage the analogy between cellular recognition and the discriminatory activity of antibodies and enzymes was emphasised. A vital conceptual advance, expressed most c1early by Linus Pauling and Paul Weiss, was the idea that non-covalent molecular interactions (of proteins in particular) were responsible forbiological specificity in in general. In the last decade several major advances have led to a new level of understanding of the molecular basis of cellular recognition. In several systems (in particular with neurotransmitters, hormones and antigens) it is possible to direct1y demonstrate the existence of receptors - associated in each case with the cell surface. These studies have been paralleled by equally important insights into the general structure and organisation of cell membranes and the possible ways in which signals arriving from the ''outside'' can be transduced across the cell surface membrane to induce or regulate the cell''s programmed responses.

Levy, 10 Po: General Summary of the Meeting 507 Subject Index 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 515 1 Also special Lecture for the Wilsede Joint Meeting on Pediatric Oncolo- gy II 2 Were also presented in the Wilsede Joint Meeting on Pediatric Oncology II 3 Presented in the Wilsede Joint Meeting on Pediatric Oncology II xv Participants of the Meeting Anders, Fritz, Genetisches Institut der Universitaet, Heinrich-ButT-Ring 58-62,6300 Giessen, Federal Republic of Germany Bauer, Georg, Institut fuer Virologie im Zentrum fUr Hygiene, Hermann- Herder-Strasse 11,7800 Freiburg, Federal Republic of Germany Bell, Richard, Medical Oncology University Hospital, 75 East Newton Street, Boston, MA 02062, USA Bernhard, Silke, Dahlem-Konferenzen, Wallotstrasse 19, 1000 Berlin 33, Federal Republic of Germany Bister, Klaus, Max-Planck-Institut fUr Molekulare Genetik, Ihnestrasse 63-73, 1000 Berlin 33, Federal Republic of Germany Blattner, William A. , Family Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Landow Building, Rm.4C18, 7910 Woodmont Avenue, Bethesda, MD 20205, USA Boiron, Michel, Institut de Recherches sur les Leucemies et les Maladies du Sang, Universite Paris VII, Hopital Saint-Louis, 2 Place du Docteur-Four- nier, 75475 Paris Cedex 10, France Boniver, Jacques, Institut de Pathologie B 23, Laboratoire d'Anatomie, Pathologique, 4000 Liege, Belgium Bornkamm, Georg W. , Institut fuer Virologie im Zentrum fuer Hygiene, Hermann-Herder-Strasse 11,7800 Freiburg, Federal Republic of Germany Burgess, Antony W.