Manyuan Long - Böcker

This work addresses the origin and evolution of new gene functions. Although interest in evolutionary novelties can be traced back to the time of Darwin, the appreciation and systematical experimental pursuit of the origin and evolution of new gene functions did not appear until the early 1990s. Sixteen chapters from pioneers and leading scientists in this emerging field provide overviews of how new genes with novel functions originated and evolved. Broad issues related to new gene evolution are analyzed, ranging from molecular mechanisms to population genetics to theoretical conjecture of the minimum building blocks for protein diversity. Both insightful reviews and original results of theoretical and experimental analyses are presented, which should be valuable for researchers and students in further pursuit of the field of new gene evolution.

In the second phase of new gene evolution, conventional models of new gene evolution, and systematical experimental pursuit of the origin and evolution of new gene functions did not appear for example by gene duplication, held that the muta­ until the early years of last decade.

This book commemorates the eclectic intellectual life of scientist and artist Walter Gilbert. It presents all of his most influential works throughout his scientific career. His scientific explorations covered a broad spectrum of fields: theoretical physics; molecular biology, from finding messenger RNA to elucidating the regulation of the lac operon to understanding DNA replication; gene evolution and origin of life; genomics; bioinformatics; and beyond. He created widely used concepts such as "Exon", "Intron" and "RNA World". Eleven reflective essays by Gilbert are included for the first time, discussing both his scientific studies and anecdotes from his own life. These firsthand accounts record the historical and intellectual contexts for his most monumental scientific discoveries, including his Nobel Prize-winning sequencing method. Memorial chapters, contributed by Gilbert Laboratory alumni, describe the passion, ambition, and efforts of Gilbert and several generations of young scientists under his leadership. Finally, the book collects a few fine pieces of artwork created by Gilbert in recent years. It documents a life of genius and creativity that could inspire others for years to come.