M.D. Cooper - Böcker

The subject of immune deficiency has become of special importance for two reasons. First, conditions with well defined defects in the immune system could be analyzed as "experiments of nature" in terms of finding out the accurate biological relevance of the defective link in the immune system. Secondly, the recognition of immune deficiency states has become important in order to provide the patients with the treatment necessary to remedy these defects. With regard to immune deficiency states in patients, these have been instrumental as "experiments of nature" in the revelation by Drs. Good and Cooper and their associates of the two-component structure of the immune system, a discovery which can be consi­ dered as a major breakthrough in the history of immunopathology. Today's research allows us to go far beyond this basic two­ component structure with the assessment of disorders affecting either cell to cell interactions or regarding subsets of lymphocyte populations. Furthermore, the association of immune deficiency with distinct enzymatic defects of purine metabolism is opening the door to the molecular level of immune deficiency. Dr. Cooper and Dr. Lawton have succeeded in obtaining the collaboration of the leaders in the field of immune deficiency. In view of the importance of their contributions in scientific and clinical terms, we decided to prepare a book version of the two issues of Seminars in Immunopathology devoted to this subject.

The topics of this volume include regulation of the helper T cell subset involved in inflammatory responses versus the subset of helper T cells involved in promoting B cells responses in humoral immunity, the regulation of T cell activity in inflammatory and autoimmune disease by the tumor necrosis factor superfamily of receptors and their ligands, the wide array of inhibitory and activating receptor that regulate natural killer cell function, phylogeny of Ig gene superfamily members linked to the major histocompatibility gene complex, the IgFc receptor family and a newly discovered family of Fc receptor homologs, the role of complement in linking innate and adaptive immunity, and manipulation of the potential for plants to protect themselves by innate and adaptive responses to viruses.