Michael Robertson Rose - Böcker

Methuselah Flies presents a trailblazing project on the biology of aging. It describes research on the first organisms to have their lifespan increased, and their aging slowed, by hereditary manipulation. These organisms are fruit flies from the species Drosophila melanogaster, the great workhorse of genetics. Michael Rose and his colleagues have been able to double the lifespan of these insects, and improved their health in numerous respects as well. The study of these flies with postponed aging is one of the best means we have of understanding, and ultimately achieving, the postponement of aging in humans. As such, the carefully presented detail of this book will be of value to research devoted to the understanding and control of aging.Methuselah Flies:• is a tightly edited distillation of twenty years of work by many scientists• contains the original publications regarding the longer-lived fruit flies• offers commentaries on each of the topics covered — new, short essays that put the individual research papers in a wider context• gives full access to the original data • captures the scientific significance of postponed aging for a wide academic audience

The purpose of this Primer is to explain the principles of Experimental Evolution. It illustrates how evolution experiments should be properly designed to examine fundamental principles of evolution and answer big questions in biology. The need for this primer has increased with the recent advances in genomics, because the functional significance of genetic variation is not easily understood without an evolutionary lens. We believe that experimental evolution can take a leading role in meeting this challenge. We explain how experimental evolution allows strong inferences while testing the evolutionary mechanisms and dynamics that shape organismal functions. Using exemplary studies, we demonstrate how evolution experiments allow researchers to probe deeply into the genomic basis of adaptation by natural selection, by which, in the words of Charles Darwin, "endless forms most beautiful and most wonderful have been, and are being, evolved."