Mohammed Tarique – författare

This book provides an overview of the latest advancements in the use of 3D organoids and stem cells for regenerative endodontics. It begins with an introduction to the foundational techniques for 3D organoid culture and explores cutting-edge developments in 3D bioprinting specifically tailored for dental applications. The book further examines the role of organoids in drug screening, toxicity testing, and the modulation of immune responses. It discusses the role of the microenvironment in organoid development, detailing how biophysical and biochemical factors, along with engineered niches, can influence the growth and functionality of organoids. The book reviews the use of various types of stem cells in regenerative endodontic therapies. The book explores the complex cellular and molecular interactions within organoid cultures, including stem cell-macrophage crosstalk and key signaling pathways involved in tissue regeneration. The role of the extracellular matrix (ECM) and different types of scaffolds, including nanofibrous, injectable scaffolds, bioinks, and decellularized extracellular matrices, are discussed for their importance in supporting 3D organoid integration and biocompatibility.Key Features:· Explores cutting-edge techniques for 3D organoid culture and bioprinting designed for dental applications· Examines the role of organoids in drug screening, toxicity testing, and immune response modulation within endodontic research· Highlights the importance of the microenvironment in organoid development· Presents innovative scaffolds and biomaterials, such as nanofibrous scaffolds, bioinks, and decellularized extracellular matrices, for enhanced integration and biocompatibility in 3D organoid-based therapies· Explores cutting-edge developments in 3D bioprinting technologies tailored for dental tissue engineeringThis book is intended for researchers of tissue engineering, regenerative medicine, and endodontics and clinicians.

This book presents the fundamental principles, contemporary methodologies, and practical applications that define modern computer-aided drug design. It explores the integration of Cryo-EM structures, AlphaFold predictions, and homology modeling to expand structural insight into biologically relevant targets. In addition, it covers molecular docking, molecular dynamics simulations, enhanced sampling approaches, and free energy calculations for robust hit-to-lead refinement. The book further examines in silico ADMET prediction, quantitative structure–activity relationships, machine learning–based modeling, and network pharmacology frameworks applied across therapeutic areas including oncology, infectious diseases, neurodegenerative disorders, and metabolic and cardiovascular conditions.Key Features: Explores foundational and advanced CADD techniques, including molecular docking, molecular dynamics simulations, in silico ADMET prediction, and network pharmacologyIntegrates Cryo-EM, AlphaFold, and homology modeling to enhance structure-based drug discoveryDetails machine learning applications for pharmacokinetic profiling, toxicity prediction, and lead prioritizationDiscusses computational workflows to multi-target drug design across major therapeutic domainsPresents systems biology perspectives and translational case examples linking computational discovery to experimental validationThis book is intended for researchers and students in pharmaceutical sciences, computational biology, bioinformatics, and related disciplines.

This book presents the molecular basis, host–parasite interactions, and translational advances in malaria research, with a specific focus on Plasmodium falciparum. It examines parasite pathogenesis, including life cycle progression, erythrocyte invasion, cytoadherence, and immune evasion mechanisms that drive clinical disease. The book explores advances in parasite genomics and functional genomics, highlighting genome engineering approaches such as CRISPR-based editing for gene function analysis and drug target validation. It also covers contemporary malaria diagnostic strategies, including molecular and point-of-care platforms designed for sensitive detection and surveillance in low-transmission settings. In addition, the book discusses epitranscriptomic regulation and genetic determinants of antimalarial drug resistance, integrating molecular mechanisms with parasite adaptation under drug pressure. The final sections address antimalarial drug discovery, emphasizing natural products and modern target-based approaches for the development of new therapeutic agents.Key Features: 1) Examines the molecular mechanisms underlying Plasmodium pathogenesis, host-parasite interactions, and cellular invasion processes2) Explores CRISPR-based genome editing for target validation and functional genomics in malaria research.3) Reviews the latest molecular diagnostics, biosensor platforms, and rapid point-of-care technologies.4) Examines host immunity, immunopathology, and parasite-driven immune evasion mechanisms.5) Discusses drug resistance mechanisms, gene-editing-based target identification, and novel therapeutic strategies.This book is intended for researchers and students of molecular parasitology, immunology, and infectious diseases.

This book reviews the current applications and future prospects of nanomaterials in cancer diagnostics and therapy.

This book reviews the current applications and future prospects of nanomaterials in cancer diagnostics and therapy.

This book discusses advancements in the applications of nanoparticles in tissue engineering. The book also analyzes the implication of three-dimensional and four-dimensional fabrication techniques for the production of the scaffold in tissue engineering and their advantages over conventional scaffold production techniques.

This book discusses advancements in the applications of nanoparticles in tissue engineering. It examines the applications of nanobiomaterials in hard tissue regeneration, fabrication, and characterization. The book also analyzes the implication of three-dimensional and four-dimensional fabrication techniques for the production of the scaffold in tissue engineering and their advantages over conventional scaffold production techniques. Further, it presents smart materials used in making 4-D scaffolds that imitate the dynamic response of tissue against natural stimuli and adapt to the microenvironment by changing their conformation or other properties. It also summarizes the growing field of biomolecular detection and biosensors in tissue engineering and the increasing prominence of nanoparticles in the biosensors. Further, it provides the future outlook and associated challenges of the application of nanomaterials in tissue engineering.

This book offers a comprehensive exploration of malaria, a life-threatening disease affecting millions globally, with a focus on the parasitic organisms of the genus Plasmodium that cause it.