Richard M. Eglen - Böcker

This book explores several subtypes of muscarinic receptors that modulate smooth muscle activity. Main topics include a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, the role of muscarinic receptors in the function of gastrointestinal and genitourinary smooth muscle, and prejunctional muscarinic receptors in smooth muscle. Discussions cover the current state of research and are intended to generate further research into the design of novel therapeutics for disorders of smooth muscle function.

From the contents: * C. Brater and M. D. Murray: The effects of NSAIDs on the kidney * G. Edwards and A. H. Weston: Latest developments in potassium channel modulator drugs * M.R. Juchau and Y. Huang: Chemical teratogenesis in humans: Biochemical and molecular mechanisms * S.P. Gupta: Studies on cardiovascular drugs * G. Polak: Antifungal chemotherapy: An everlasting battle * O. Valdenaire: New insights into the bioamine receptor family

This book provides a comprehensive, up-to-date review of the distribution, pharmacology and physiology of central 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes exhibit a unique pharmacology, distribution and function, of which the 5-HT4 receptor has been one of the most intensively studied in recent years, both from a basic research standpoint and as a target for novel therapeutics.