Roberto Pontremoli – författare

Hypertension, the leading modifiable cause of premature death, affects the great majority of patients with chronic kidney disease (CKD).  The book will cover the epidemiology of CKD and hypertension and provide  an in-depth review of pathophysiological mechanisms linking these conditions, as well as the implications of this association in terms of cardiovascular risk. The reader will also find up-to-date evidence and guidelines for the screening, diagnosis and real-life management of patients with hypertension and chronic kidney disease and more importantly data and critical assessment of latest trials with new disease modifying treatment.Among the topic covered in the book: the usefulness of out of office BP measurement, the role of albuminuria as a marker of risk and as a therapeutic target, the role of serum uric acid and salt intake in the prognosis and clinical management of CKD patients. The expanding therapeutic armamentarium to prevent hypertensive renal damage in diabetic and non diabetic patients will be reviewed, RAAS Is, SGLT2 is, drugs modulating aldosterone pathway  as well as new antihyperglycemic drugs. A chapter will cover resistant hypertension and its treatment by drugs and the use of renal denervation for CV and renal protection. Furthermore, updates on renovascular hypertension and preeclampsia will be provided. This book is a useful tool for clinicians but also to the research community interested in CKD and hypertension related renal damage who want to be up-to-date with the many new developments in the field.

This book guides readers through a wide spectrum of clinical presentations in patients with arterial hypertension and different degrees of renal impairment, ranging from asymptomatic urine abnormalities to end stage renal disease. On the basis of six case studies, the author reviews and discusses current guidelines and recommendations aimed at optimizing the diagnostic and therapeutic approach both to renal and cardiovascular risk in commonly encountered real-world clinical scenarios including challenging cases of diabetic kidney disease, ischemic nephropathy and resistant hypertension. It also explores anti-hypertensive drug combinations, including single or multiple RAAS-I, lipid lowering and antiplatelet drugs, as well as the appropriate use of glucose lowering drugs in the context of chronic kidney disease. This handy and practical book provides physicians in the area of general and internal medicine, as well as specialists in the cardiovascular, metabolic and renal fields valuable insights into optimal therapeutic targets for blood pressure and glucose control in renal patients.