Tatsuya Akutsu – författare

High-throughput sequencing and functional genomics technologies have given us the human genome sequence as well as those of other experimentally, medically, and agriculturally important species, thus enabling large-scale genotyping and gene expression profiling of human populations. Databases containing large numbers of sequences, polymorphisms, structures, metabolic pathways, and gene expression profiles of normal and diseased tissues are rapidly being generated for human and model organisms. Bioinformatics is therefore gaining importance in the annotation of genomic sequences; the understanding of the interplay among and between genes and proteins; the analysis of the genetic variability of species; the identification of pharmacological targets; and the inference of evolutionary origins, mechanisms, and relationships. This proceedings volume contains an up-to-date exchange of knowledge, ideas, and solutions to conceptual and practical issues of bioinformatics by researchers, professionals, and industry practitioners at the 6th Asia-Pacific Bioinformatics Conference held in Kyoto, Japan, in January 2008.

This volume contains 18 peer-reviewed papers based on the presentations at the 10th Annual International Workshop on Bioinformatics and Systems Biology (IBSB 2010) held at Kyoto University from July 26 to July 28, 2010. This workshop started in 2001 as an event for doctoral students and young researchers to present and discuss their research results and approaches in bioinformatics and systems biology. It is part of a collaborative educational program involving leading institutions and leaders committed to the following programs:Boston — Graduate Program in Bioinformatics, Boston University Berlin — The International Research Training Group (IRTG) “Genomics and Systems Biology of Molecular Networks”Kyoto — The JSPS International Training Program (ITP) “International Research and Training Program of Bioinformatics and Systems Biology”Tokyo — Global COE Program “Center of Education and Research for Advanced Genome-Based Medicine”

This book explores the intersection of control theory and complex network science through the framework of structural controllability of complex networks. It introduces the main concepts, mathematical formulations, and computational algorithms needed to analyze the controllability of large-scale networked systems.Covering topics from basic control theory and graph-based methods to mathematical models and data-driven approaches, the book describes current applications of network controllability in social, engineering, and biological systems, with particular emphasis on biological networks. It thus offers an interdisciplinary view of a rapidly developing research area and highlights the growing importance of controllability analysis in complex real-world systems.It will be useful to researchers and graduate students in network science, systems biology, control theory, robotics, and related areas of engineering.