This text illustrates bone marrow aspirate, imprint and biopsy specimens showing characteristic features of a wide variety of neoplastic and non-neoplastic conditions. While the focus is on Wright-stained smears and hematoxylin-eosin stained biopsies, other key histochemical and immunohistochemical stains are illustrated that are vital for proper diagnosis.  After a brief review of the normal bone marrow, reactive changes in the marrow are illustrated, including the bone marrow response in constitutional disorders and to metabolic changes throughout the body.  This is followed by specific infectious disorders in the marrow and other non-neoplastic disorders.  The remainder of the Atlas illustrates the various neoplasms that involve the bone marrow, including leukemias, lymphomas and non-hematopoietic neoplasms.  The hematologic neoplasms are classified using the 2016 World Health Organization (WHO) classification.  This overview of bone marrow disorders illustrates a wide variety of diseases that practicing pathologists and hematologists will encounter in their routine practice.​

This text illustrates bone marrow aspirate, imprint and biopsy specimens showing characteristic features of a wide variety of neoplastic and non-neoplastic conditions. While the focus is on Wright-stained smears and hematoxylin-eosin stained biopsies, other key histochemical and immunohistochemical stains are illustrated that are vital for proper diagnosis.  After a brief review of the normal bone marrow, reactive changes in the marrow are illustrated, including the bone marrow response in constitutional disorders and to metabolic changes throughout the body.  This is followed by specific infectious disorders in the marrow and other non-neoplastic disorders.  The remainder of the Atlas illustrates the various neoplasms that involve the bone marrow, including leukemias, lymphomas and non-hematopoietic neoplasms.  The hematologic neoplasms are classified using the 2016 World Health Organization (WHO) classification.  This overview of bone marrow disorders illustrates a wide variety of diseases that practicing pathologists and hematologists will encounter in their routine practice.​

This text illustrates bone marrow aspirate, imprint and biopsy specimens showing characteristic features of a wide variety of neoplastic and non-neoplastic conditions. While the focus is on Wright-stained smears and hematoxylin-eosin stained biopsies, other key histochemical and immunohistochemical stains are illustrated that are vital for proper diagnosis.  After a brief review of the normal bone marrow, reactive changes in the marrow are illustrated, including the bone marrow response in constitutional disorders and to metabolic changes throughout the body.  This is followed by specific infectious disorders in the marrow and other non-neoplastic disorders.  The remainder of the Atlas illustrates the various neoplasms that involve the bone marrow, including leukemias, lymphomas and non-hematopoietic neoplasms.  The hematologic neoplasms are classified using the 2016 World Health Organization (WHO) classification.  This overview of bone marrow disorders illustrates a wide variety of diseases that practicing pathologists and hematologists will encounter in their routine practice.​

One of the main reasons that this edition was undertaken is that for some years there has been no single, up-to-date book containing extensive information on benign and reactive lymphoid conditions. Although malignant processes garner the majority of attention, it is the benign processes that have an underlying complexity that is often an illustration of the delicate interplay of many components of the active immune system.In diagnosing the pathologic specimen, a basic approach is:1. To determine if the process is benign or malignant.2. If malignant, to characterise the origin of the malignancy.3. To subclassify or identify the process.In some cases, the first part—the question of benign versus malignant—cannot be resolved by histomorphologic evaluation alone. The second part of the approach has become considerably easier with the advent of immunophenotypic analysis. The final issue, that of identification of the pathologic process, may be of greater or lesser importance, depending on the clinical situation.If an exact diagnosis can be made it can have several benefits. In the case of neoplastic processes, it may indicate the type of treatment and the prognosis. In benign processes, there are other important benefits as well. Although some therapies may be instituted in benign conditions, often simply naming a thing can have great benefit to the patient. It is important to realise that even in the case of a purely reactive process, finding a name, a category, a classification, can provide real peace of mind to the patient. As the American Journal of Clinical Pathology declares, “The hundreds of images are the greatest asset of this book. There are extraordinary renditions of such exquisite classic (yet rarely illustrated) entities: ‘sago’ and ‘lardaceous’ spleens, ‘lollipop’ and ‘explosive’ lymphoid follicles, multinucleated measles cells and hyperplastic mesothelial inclusions, and sundry mystifying diseases, including those known eponymously: Kawasaki, Kikuchi, and Kimura.”For pathologists and hematopathologists specifically, the authors have created a book that will serve for years as a useful guide to the multifaceted world of benign and reactive lesions of the lymphoid system.

This text illustrates bone marrow aspirate, imprint and biopsy specimens showing characteristic features of a wide variety of neoplastic and non-neoplastic conditions. While the focus is on Wright-stained smears and hematoxylin-eosin stained biopsies, other key histochemical and immunohistochemical stains are illustrated that are vital for proper diagnosis.  After a brief review of the normal bone marrow, reactive changes in the marrow are illustrated, including the bone marrow response in constitutional disorders and to metabolic changes throughout the body.  This is followed by specific infectious disorders in the marrow and other non-neoplastic disorders.  The remainder of the Atlas illustrates the various neoplasms that involve the bone marrow, including leukemias, lymphomas and non-hematopoietic neoplasms.  The hematologic neoplasms are classified using the 2016 World Health Organization (WHO) classification.  This overview of bone marrow disorders illustrates a wide variety of diseases that practicing pathologists and hematologists will encounter in their routine practice.​

This text illustrates bone marrow aspirate, imprint and biopsy specimens showing characteristic features of a wide variety of neoplastic and non-neoplastic conditions. While the focus is on Wright-stained smears and hematoxylin-eosin stained biopsies, other key histochemical and immunohistochemical stains are illustrated that are vital for proper diagnosis.  After a brief review of the normal bone marrow, reactive changes in the marrow are illustrated, including the bone marrow response in constitutional disorders and to metabolic changes throughout the body.  This is followed by specific infectious disorders in the marrow and other non-neoplastic disorders.  The remainder of the Atlas illustrates the various neoplasms that involve the bone marrow, including leukemias, lymphomas and non-hematopoietic neoplasms.  The hematologic neoplasms are classified using the 2016 World Health Organization (WHO) classification.  This overview of bone marrow disorders illustrates a wide variety of diseases that practicing pathologists and hematologists will encounter in their routine practice.​

This text illustrates bone marrow aspirate, imprint and biopsy specimens showing characteristic features of a wide variety of neoplastic and non-neoplastic conditions. While the focus is on Wright-stained smears and hematoxylin-eosin stained biopsies, other key histochemical and immunohistochemical stains are illustrated that are vital for proper diagnosis.  After a brief review of the normal bone marrow, reactive changes in the marrow are illustrated, including the bone marrow response in constitutional disorders and to metabolic changes throughout the body.  This is followed by specific infectious disorders in the marrow and other non-neoplastic disorders.  The remainder of the Atlas illustrates the various neoplasms that involve the bone marrow, including leukemias, lymphomas and non-hematopoietic neoplasms.  The hematologic neoplasms are classified using the 2016 World Health Organization (WHO) classification.  This overview of bone marrow disorders illustrates a wide variety of diseases that practicing pathologists and hematologists will encounter in their routine practice.​

One of the main reasons that this edition was undertaken is that for some years there has been no single, up-to-date book containing extensive information on benign and reactive lymphoid conditions. Although malignant processes garner the majority of attention, it is the benign processes that have an underlying complexity that is often an illustration of the delicate interplay of many components of the active immune system.In diagnosing the pathologic specimen, a basic approach is:1. To determine if the process is benign or malignant.2. If malignant, to characterise the origin of the malignancy.3. To subclassify or identify the process.In some cases, the first part—the question of benign versus malignant—cannot be resolved by histomorphologic evaluation alone. The second part of the approach has become considerably easier with the advent of immunophenotypic analysis. The final issue, that of identification of the pathologic process, may be of greater or lesser importance, depending on the clinical situation.If an exact diagnosis can be made it can have several benefits. In the case of neoplastic processes, it may indicate the type of treatment and the prognosis. In benign processes, there are other important benefits as well. Although some therapies may be instituted in benign conditions, often simply naming a thing can have great benefit to the patient. It is important to realise that even in the case of a purely reactive process, finding a name, a category, a classification, can provide real peace of mind to the patient. As the American Journal of Clinical Pathology declares, “The hundreds of images are the greatest asset of this book. There are extraordinary renditions of such exquisite classic (yet rarely illustrated) entities: ‘sago’ and ‘lardaceous’ spleens, ‘lollipop’ and ‘explosive’ lymphoid follicles, multinucleated measles cells and hyperplastic mesothelial inclusions, and sundry mystifying diseases, including those known eponymously: Kawasaki, Kikuchi, and Kimura.”For pathologists and hematopathologists specifically, the authors have created a book that will serve for years as a useful guide to the multifaceted world of benign and reactive lesions of the lymphoid system.