Vadim N. Gladyshev – författare

The discovery of selenoproteins in 1973 was the starting point for today''s flourishing selenium field [1,2]. It provided evidence that selenium had biochemical functions that could account for its nutritional effects [3,4]. Further, it opened the selenium field to investigation by the methods of biochemistry, which led to the identification of several more selenoproteins and showed that selenocysteine was the form of the element in animal selenoproteins and in most bacterial ones. Although noteworthy efforts were made to uncover the mechanism of selenocysteine and selenoprotein synthesis using biochemical methods, the problem yielded only when attacked with the methods of molecular biology [5,6]. The bacterial mechanism was characterized first; characterization of the animal mechanism is a work in progress. It is interesting to note that the only genes that are devoted to selenium metabolism are those that support selenoprotein synthesis and selenocysteine catabolism. Consequently, it seems likely that competition for selenium between selenoprotein synthesis and the production of selenium excretory metabolites [7] controls who- body selenium homeostasis. The physiological functions of selenium derive fi-om the catalytic and physical properties of selenoproteins. Selenoproteins such as the glutathione peroxidases and the thioredoxin reductases have redox activities that allow them to serve in oxidant defense. The deiodinases use their redox activities to activate and inactivate thyroid hormones. From these two examples, it can be seen that selenoprotein functions are diverse while having in common a redox mechanism.

Many health benefits have been attributed to selenium that include preventing various forms of cancer (e.g., colon cancer, prostate cancer, lung cancer and liver cancer), heart disease and other cardiovascular and muscle disorders, inhibiting viral expression, delaying the progression of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-positive patients, slowing the aging process, and having roles in mammalian development, including male reproduction and immune function. The purpose of the book is the same as the first two volumes which is to bring an up to date status of current research in the rapidly developing selenium field centered around the health benefits attributed to this element and how this element makes its way into protein.

Many health benefits have been attributed to selenium that include preventing various forms of cancer (e.g., colon cancer, prostate cancer, lung cancer and liver cancer), heart disease and other cardiovascular and muscle disorders, inhibiting viral expression, delaying the progression of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-positive patients, slowing the aging process, and having roles in mammalian development, including male reproduction and immune function. The purpose of the book is the same as the first two volumes which is to bring an up to date status of current research in the rapidly developing selenium field centered around the health benefits attributed to this element and how this element makes its way into protein.

In the current edition, Selenium: Its Molecular Biology and Role in Human Health expands extensively on the previous editions providing readers with the most significant advances in the rapidly developing selenium field. Evidence from epidemiology and veterinary science supports the essential role of selenium in (human) health, but its split personality in both preventing and supporting cancer and also in promoting insulin resistance has become more clearly defined. The pivotal role of glutathione peroxidase 4 in a new process of programmed cell death, ferroptosis, brings new impetus to the field. Recently defined mutations in selenoprotein and biosynthesis factor genes have been identified in patients, and the resulting disorders further emphasize the significance of selenoproteins in human health. The mechanism of selenoprotein biosynthesis, the functions of selenoproteins, and the roles of dietary selenium have been further elucidated, and new regulatory mechanisms involvingselenoproteins discovered. The book, therefore, covers the breadth of current selenium research. With up-to-date chapters written by leaders in their fields, it serves as an invaluable resource for novices as well as specialists.

In the current edition, Selenium: Its Molecular Biology and Role in Human Health expands extensively on the previous editions providing readers with the most significant advances in the rapidly developing selenium field. Evidence from epidemiology and veterinary science supports the essential role of selenium in (human) health, but its split personality in both preventing and supporting cancer and also in promoting insulin resistance has become more clearly defined. The pivotal role of glutathione peroxidase 4 in a new process of programmed cell death, ferroptosis, brings new impetus to the field. Recently defined mutations in selenoprotein and biosynthesis factor genes have been identified in patients, and the resulting disorders further emphasize the significance of selenoproteins in human health. The mechanism of selenoprotein biosynthesis, the functions of selenoproteins, and the roles of dietary selenium have been further elucidated, and new regulatory mechanisms involvingselenoproteins discovered. The book, therefore, covers the breadth of current selenium research. With up-to-date chapters written by leaders in their fields, it serves as an invaluable resource for novices as well as specialists.