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Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

In the past two decades, several pandemics have ravaged the globe, giving us several lessons on infectious disease epidemiology, the importance of initial detection and characterization of outbreak viruses, the importance of viral epidemic prevention steps, and the importance of modern vaccines. Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment summarizes the improvements in the 21st century to overcome / prevent / treat global pandemic with future prospective.

Divided into 9 chapters, the book begins with an in-depth introduction to the lessons learned from the first pandemic of the 21st century. It describes the history, present and future in terms of detection, prevention and treatment. Followed by chapters on the outbreak, treatment strategies and clinical management of several infectious diseases like MERS, SARD and COVID 19, Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment, presents chapters on immunotherapies and vaccine technologies to combat pandemic outbreak and challenges. The book finishes with a chapter on the current knowledge and technology to control pandemic outbreaks.

All are presented in a practical short format, making this volume a valuable resource for very broad academic audience.

Provides insight to the lessons learned from past pandemicsGives recommendations, future direction in terms of detection, prevention and treatment of pandemicsGuides readers through the status and recent developments of vaccines to overcome or prevent pandemicsShows how to enhance the host innate immunity in infectious diseasesIncludes a chapter on immunotherapies to combat pandemic outbreaks

Increasing Management Relevance and Competitiveness contains the papers presented at the Global Conference on Business, Management and Entrepreneurship (the 2nd GC-BME 2017), Surabaya, Indonesia on the 9th of August, 2017.The book covers 7 topics:1. Organizational Behavior, Leadership, and Human Resources Management2. Innovation, Operations and Supply Chain Management3. Marketing Management4. Financial Management and Accounting5. Strategic Management, Entrepreneurship, and Contemporary Issues6. Green Business7. Management and Economics Education.

Focusing on the challenges, directions, and future predictions with the role of 5G in smart healthcare monitoring, this book offers the fundamental concepts and analyses on the methods to apply Internet of Things (IoT) in monitoring devices for diagnosing and transferring data. It also discusses self-managing to help providers improve their patients' healthcare experience.Smart Healthcare Monitoring Using IoT with 5G: Challenges, Directions, and Future Predictions illustrates user-focused wearable devices such as Fitbit health monitors and smartwatches by which consumers can self-manage and self-monitor their own health. The book covers new points of security and privacy concerns, with the expectation of IoT devices gaining more popularity within the next ten years. Case studies depicting applications and best practices as well as future predictions of smart healthcare monitoring by way of a 5G network are also included.Interested readers of this book include anyone working or involved in research in the field of smart healthcare, such as healthcare specialists, computer science engineers, electronics engineers, and pharmaceutical practitioners.

Focusing on the challenges, directions, and future predictions with the role of 5G in smart healthcare monitoring, this book offers the fundamental concepts and analyses on the methods to apply Internet of Things (IoT) in monitoring devices for diagnosing and transferring data. It also discusses self-managing to help providers improve their patients' healthcare experience.Smart Healthcare Monitoring Using IoT with 5G: Challenges, Directions, and Future Predictions illustrates user-focused wearable devices such as Fitbit health monitors and smartwatches by which consumers can self-manage and self-monitor their own health. The book covers new points of security and privacy concerns, with the expectation of IoT devices gaining more popularity within the next ten years. Case studies depicting applications and best practices as well as future predictions of smart healthcare monitoring by way of a 5G network are also included.Interested readers of this book include anyone working or involved in research in the field of smart healthcare, such as healthcare specialists, computer science engineers, electronics engineers, and pharmaceutical practitioners.

Physical Modelling in Geotechnics collects more than 1500 pages of peer-reviewed papers written by researchers from over 30 countries, and presented at the 9th International Conference on Physical Modelling in Geotechnics 2018 (City, University of London, UK 17-20 July 2018). The ICPMG series has grown such that two volumes of proceedings were required to publish all contributions. The books represent a substantial body of work in four years. Physical Modelling in Geotechnics contains 230 papers, including eight keynote and themed lectures representing the state-of-the-art in physical modelling research in aspects as diverse as fundamental modelling including sensors, imaging, modelling techniques and scaling, onshore and offshore foundations, dams and embankments, retaining walls and deep excavations, ground improvement and environmental engineering, tunnels and geohazards including significant contributions in the area of seismic engineering. ISSMGE TC104 have identified areas for special attention including education in physical modelling and the promotion of physical modelling to industry. With this in mind there is a special themed paper on education, focusing on both undergraduate and postgraduate teaching as well as practicing geotechnical engineers. Physical modelling has entered a new era with the advent of exciting work on real time interfaces between physical and numerical modelling and the growth of facilities and expertise that enable development of so called ‘megafuges’ of 1000gtonne capacity or more; capable of modelling the largest and most complex of geotechnical challenges. Physical Modelling in Geotechnics will be of interest to professionals, engineers and academics interested or involved in geotechnics, geotechnical engineering and related areas. The 9th International Conference on Physical Modelling in Geotechnics was organised by the Multi Scale Geotechnical Engineering Research Centre at City, University of London under the auspices of Technical Committee 104 of the International Society for Soil Mechanics and Geotechnical Engineering (ISSMGE). City, University of London, are pleased to host the prestigious international conference for the first time having initiated and hosted the first regional conference, Eurofuge, ten years ago in 2008. Quadrennial regional conferences in both Europe and Asia are now well established events giving doctoral researchers, in particular, the opportunity to attend an international conference in this rapidly evolving specialist area.This is volume 1 of a 2-volume set.

No girls allowed? Not anymore! Today's female athletes have an equal shot at playing sports and even going pro. It is all thanks to Title IX, a law that protects their rights in sports and more. Decades later, the law is still evolving-and still going strong. Learn more about the law that brought equality to sports with this nonfiction reader featuring TIME For Kids content. The detailed images and sidebars, stimulating facts, and clear, informational text will engage students as they build their critical literacy skills. The Reader's Guide, Dig Deeper, and Try It! sections prompt students to connect back to the text, and provide extensive language-development activities that will develop critical thinking. The book includes text features such as a table of contents, glossary, and an index to increase understanding and improve academic vocabulary. Aligned with state and national standards, this text prepares students for college and career. Keep grade 5 students engaged from cover to cover with this high-interest title.

This is an exciting time to learn JavaScript. Now that the latest JavaScript specification-ECMAScript 6.0 (ES6)-has been finalized, learning how to develop high-quality applications with this language is easier and more satisfying than ever. This practical book takes programmers (amateurs and pros alike) on a no-nonsense tour of ES6, along with some related tools and techniques. Author Ethan Brown (Web Development with Node and Express) not only guides you through simple and straightforward topics (variables, control flow, arrays), but also covers complex concepts such as functional and asynchronous programming. You'll learn how to create powerful and responsive web applications on the client, or with Node.js on the server. Use ES6 today and transcompile code to portable ES5 Translate data into a format that JavaScript can use Understand the basic usage and mechanics of JavaScript functions Explore objects and object-oriented programming Tackle new concepts such as iterators, generators, and proxies Grasp the complexities of asynchronous programming Work with the Document Object Model for browser-based apps Learn Node.js fundamentals for developing server-side applications

This book provides comprehensive coverage on the concepts, frameworks, and underpinning technologies in most aspects of the Internet of Things (IoT), and presents them as the foundation on which more advanced topics, such as 5G and mMTC/M2M, Edge/cloud computing and the modalities of Tactile IoT, Industrial IoT (IIoT)/Industry 4.0, Satellite IoT, and Digital Twins (DT), could be built upon.A key feature of the book is the chapter that focuses on security and privacy for individuals and IoT/ Industry 4.0 are discussed.This book is a good reference guide for researchers, developers, integrators and stakeholders working on research in or development of IoT, particularly where open-source software are deployed.