Häftad, Engelska, 2023
Transcription and Translation in Health and Disease
Av Manoj Garg, Gautam Sethi, Amit Kumar Pandey
1626 kr
Beställningsvara. Skickas inom 11-20 vardagar. Fri frakt över 249 kr.
Beskrivning
Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications.
It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention.
- Discusses the role played by transcription and translational regulation in various diseases, including cancer, diabetes, cardiovascular disease and neurological disease
- Considers a range of post-transcriptional regulators, including RNA-binding proteins, non-coding RNAs, epigenetic modifiers, alternative splicing and telomerase-binding proteins
- Covers the topic from fundamental knowledge to the latest developments in clinical application
- Includes a section dedicated to therapeutic applications
Produktinformation
- Utgivningsdatum: 2023-02-02
- Mått: 191 x 235 x 25 mm
- Vikt: 450 g
- Format: Häftad
- Språk: Engelska
- Antal sidor: 416
- Förlag: Elsevier Science
- ISBN: 9780323995214
Utforska kategorier
Mer om författaren
Dr. Manoj Garg completed his PhD at the National Institute of Immunology (NII), New Delhi and University of Rajasthan, Jaipur, India. He joined as a Research Scientist at the Cancer Science Institute (CSI), National University of Singapore, Singapore in 2010 and extensively worked on cutting-edge technologies including next‐generation sequencing of both DNA and RNA, shRNA library screening, drug screening in different subtypes of Acute myeloid leukemia (AML), Acute Lymphocytic leukemia (ALL), esophageal squamous cell carcinoma, pancreatic carcinoma, anaplastic thyroid carcinoma, and liposarcoma. In 2016, Dr. Garg was awarded Ramalingaswami Fellowship and returned to India and joined as an Assistant Professor at Cancer Institute, Chennai. He received the Early Career Research Award from Science Engineering and Research Board (SERB), GOI in 2017. Dr. Garg has published his research in a range of well‐reputed scientific journals and serves as an editor for various international journal. Dr. Gautam Sethi is a tenured Associate Professor in the Department of Pharmacology at the Yong Loo Lin School of Medicine, National University of Singapore. His research focuses on elucidating the molecular mechanisms underlying cancer initiation and progression, particularly the activation of oncogenic transcription factors by carcinogens and inflammatory agents, and the identification of novel therapeutic inhibitors. Dr. Sethi has made substantial and direct scholarly contributions to the fields of gut microbiota, cancer pathophysiology, and host–microbiome interactions, with particular emphasis on immunotherapy, tumor microenvironment modulation, metabolic signaling, and therapy response prediction. He has authored numerous peer reviewed research and review articles in high impact journals, received multiple international awards, and serves on the editorial boards of several international journals.Dr. Amit Kumar Pandey completed his postdoctoral training at the Cancer Science Institute of Singapore, National University of Singapore, Singapore where he worked on exploring the role of miRNAs in epigenetic regulation of metastatic breast cancer, and Max Delbruck Center for Molecular Medicine, Berlin, Germany where he worked on exploring the role of non-coding RNAs in metabolism. Dr. Pandey has been working in the field of non-coding RNAs for the last 12 years. He has worked extensively in molecular and cell biology, cell signaling, next generation sequencing. For the last 3 years Dr. Pandey has been working as Assistant professor and running 4 research grants from various govt. agencies as principal investigator. Dr. Pandey currently serves as editor of PLOS One and review editor of Frontiers in Molecular Biosciences.
Recensioner i media
"... to uncover the details concerning how gene expression is controlled,… this book consists of 19 independently authored chapters designed to "bring our vast knowledge gene expression regulation under a single canopy." Given the near infinite dimensions of the subject at hand,… the goal of this book is to produce a relatively compact and up-to-date overview of transcriptional and translational gene regulatory mechanisms, [and] it is important to consider whether the wealth of knowledge on this topic is too vast to distill into a single volume.” --©Doody’s Review Service, 2023, Peter J. Kennelly, PhD (Virginia Tech)
Betyg & recensioner
0 recensioner
Inga recensioner tillgängliga.