Gautam Sethi – författare

Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications.

It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention.

Discusses the role played by transcription and translational regulation in various diseases, including cancer, diabetes, cardiovascular disease and neurological disease Considers a range of post-transcriptional regulators, including RNA-binding proteins, non-coding RNAs, epigenetic modifiers, alternative splicing and telomerase-binding proteins Covers the topic from fundamental knowledge to the latest developments in clinical application Includes a section dedicated to therapeutic applications

Phytochemicals in Cancer Therapy and Beyond explores the significant role of natural products in combating diseases, particularly cancer. The book emphasizes the mechanisms through which natural products operate in treatments, making it a comprehensive guide for understanding their therapeutic potential. Spanning 24 chapters, it delves into regular cancer treatments, challenges faced, and advancements in the field. Special focus is given to phytochemicals and their cellular mechanisms, molecular pathways in therapy, and innovative nano-scale delivery systems that enhance treatment efficacy.This book is an essential resource for oncology researchers, disease therapy experts, diabetes mellitus treatment professionals, cellular signaling scientists, and nanomaterial engineers, offering valuable insights into the clinical applications of phytochemical therapies.

Evaluates the role of natural products in the treatment of diseases, especially cancerProvides details evaluating the role of natural products in regulating cellular and molecular mechanisms in cancer therapyFocuses on the use of nanoparticles for delivery of natural products in disease therapyEncompasses a high number of schematic figures to make it easier for readers to understand conceptsDemonstrates the mechanisms that natural products follow in treatment of diseases, especially cancer therapy

Cancer Metabolism: From Molecules to Medicine delivers groundbreaking insights and the latest research into the pivotal role of cancer metabolism in oncology and therapeutic strategies. This book underscores cancer metabolism as a foundational element of cancer biology, predating even the identification of oncogenes and tumor suppressors. It reveals how, unlike normal cells, cancerous cells modify their metabolic pathways to support malignancy, providing new avenues for therapeutic intervention. This book is divided into 16 chapters, delving into the core topics of cancer cell metabolism, metabolic disorders, and autophagy's role in tumor cell metabolism. These subjects illustrate the cellular fitness enhancement via metabolic reprogramming, offering tumors a selective edge through enhanced biosynthesis, altered bioenergetics, and redox balance. This book provides a thorough exploration of how these reprogrammed metabolic processes not only support cancer cell survival and proliferation but also present viable targets for innovative cancer treatments. “Cancer Metabolism: From Molecules to Medicine” serves as an essential resource for scientists and researchers seeking an in-depth understanding of the molecular mechanisms at play in cancer metabolism and its implications for therapy. Additionally, clinicians will find value in the comprehensive coverage of how these metabolic insights translate into novel treatment strategies, bridging the gap between basic research and clinical application. The book's focus on metabolic pathways as therapeutic targets offers practitioners new tools for combating cancer, making it a must-read for both the scientific and medical communities aiming to advance their knowledge and therapeutic capabilities in the dynamic field of cancer metabolism.Delivers comprehensive details on the metabolic transformations distinguishing cancer cells from their normal counterpartsOutlines the latest advancements in anti-cancer drugs that target metabolic processes and signalling pathways, covering both existing and prospective treatmentsExplores the molecular foundations underlying the metabolic regulation of cancer cells, offering deep insights into potential therapeutic targets

Recent Advances in Targeting Inflammation: Ion Channels, GPCR Signaling Tools, Therapies, and Beyond delves into the multifaceted occurrences of inflammation across different systems, such as neuroinflammation and gastric inflammation. The book's main goal is to present the latest highlights, covering advancements in inflammation, investigational therapies, animal models, and biomarkers. These insights are crucial for better diagnosis, monitoring, and potential therapeutic options for patients suffering from both acute and chronic inflammation. This comprehensive work explores various topics, including ion channel regulation in inflammation, GPCR regulation, signaling pathways, and therapeutic approaches.It emphasizes the importance of understanding the role of ion channels, GPCR, and nutrition in managing inflammation effectively. Additionally, the book discusses the global impact of chronic inflammation on health outcomes, stressing the need for improved healthcare planning and strategies.Focuses on the development of multiple discipline approaches in inflammation and nutrition-related researchBrings together leading researchers in ion channels' regulation of inflammationPresents essential reference information for researchers in the areaProvides current developments in disease, making it a vital resource for students and industry professionals

Phytochemicals and Hallmarks of Cancer: From Molecules to Medicine delves into the potential of phytomedicine to effectively address both established and emerging hallmarks of cancer, offering valuable insights into their translational applications from bench to bedside. The book provides comprehensive information about how the plant-derived product tackles cancer by targeting different hall markers that drive cancer progression. In 12 chapters the book not only describes the implications of plant products on cancer immunotherapy, gives insight in the hurdles in clinical translating plant derived products for cancer therapy, but also focuses on the therapeutic aspects of phytochemicals, providing insights into how understanding of mechanism of actions of phytochemicals can aid to develop innovative therapies.By addressing these knowledge and information needs Phytochemicals and Hallmarks of Cancer: From Molecules to Medicine is designed to be accessible to clinicians and researchers alike in the field of phytochemical applications in medicine.Provides a detailed overview of the molecular mechanisms through which phytochemicals can modulate various hallmarks of cancerDiscusses the potential of phytochemicals to reverse the metastatic process via inhibition of migration, invasion, and angiogenesisCovers the implication of natural products as apoptosis inducers

Mitochondria-targeted Drug Delivery Strategies for Cancer Therapy explores the innovative use of biocompatible, multifunctional nanoplatforms to target mitochondria for selective drug delivery, enhancing treatment efficacy while minimizing side effects. The book provides a comprehensive overview of the role of nanotechnology in cancer treatment, reviewing the basics of nanotechnology and cancer biology, advanced nanoengineering strategies, and the development of mitochondria-targeted drug delivery systems, such as liposomal therapies, photosensitizer nanoparticles, and peptides for cancer treatment, along with strategies to modulate mitochondrial functions using nanomaterials.This is a valuable resource to researchers and scientists interested in the application of nanotechnology for improved cancer therapy as it provides a thorough overview of real-world applications and future research trends as well as a discussion on overcoming challenges in mitochondrial targeting.Reviews the principles of mitochondria-targeted drug delivery, including the design of nanocarriers, mechanisms of mitochondrial targeting, and methods for evaluating delivery efficiencyIncludes case studies and examples from recent research to illustrate the application of nanotechnology in targeting mitochondria for cancer treatmentDiscusses future research directions in the field, including emerging trends and technologies that may further advance mitochondria-targeted drug delivery for cancer treatment

As such, the proposed book serves as an indispensable resource for healthcare professionals, data scientists, researchers, and anyone invested in the future of healthcare and AI.

This book serves as a critical resource that bridges the gap between burgeoning technology and its practical implementation. The book starts with an in-depth exploration of healthcare 5.0 principles, laying the foundation for the reader to understand the current shifts in healthcare paradigms. Then, it dives into the intricacies of generative models in healthcare, detailing how these algorithms work and the applications they serve. The book further delves into the subsets of generative machine learning and deep learning techniques in healthcare. As we move towards more complex applications, the book takes a turn to address the critical subject of interpretability and explainability in generative models, a topic that resonates profoundly given the life-critical nature of medical decisions. Finally, the book concludes with a robust discussion on the security and privacy concerns that accompany the deployment of GAI in real healthcare settings. By offering a multidimensional viewpoint—coupled with case studies, statistical analyses, and expert insights—the book ensures that the reader is left with a nuanced understanding of how GAI can be both a boon and a challenge in healthcare. As such, the proposed book serves as an indispensable resource for healthcare professionals, data scientists, researchers, and anyone invested in the future of healthcare and AI.

"Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications" provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.

An Introduction to Principles and Practice of Respiratory Medicine is intended to be the first book read by postgraduates in Respiratory and Internal Medicine. It represents a broad spectrum of issues relevant to the clinician involved in managing respiratory diseases. There is material for the basic researcher as well as extensive material for the clinicians. This textbook will appeal to both graduate and postgraduate students in Respiratory Medicine, academicians and the clinicians managing patients in their day-to-day practice.A broad spectrum of issues in Respiratory Medicine is covered. The chapter on chest imaging is extensive with more than 100 illustrations in a single chapter and outlines new directions for the clinicians to approach interpretations of images. Airway diseases section is equally extensive with few chapters using the case-based problem-solving approach for easier understanding. A comprehensive overview of the respiratory system is presented thus making it easy to read and understand.

Liver Cancer and Phytomedicine systematically explores the potential of phytomedicines across three fundamental aspects of cancer management: prevention, sensitization, and therapy. This comprehensive book provides an extensive overview of the potential of important phytomedicines in managing liver cancer, encompassing areas such as prevention, sensitization therapy, modulation of gut microbiota, immunotherapy, and the emergence of phytonanomedicine. It serves as an invaluable resource for researchers and students in life sciences, biotechnology, and pharmaceutical sciences, offering insights into plant-derived therapeutics for liver cancer. The book explores the impact of phytomedicines on various facets of liver cancer biology, ranging from the tumor microenvironment to drug resistance pathways. Additionally, it discusses various clinical challenges and proposes strategies for transitioning to phytonanomedicine, providing valuable insights for researchers and clinicians engaged in developing liver cancer therapeutics.