Milad Ashrafizadeh – författare

Phytochemicals in Cancer Therapy and Beyond explores the significant role of natural products in combating diseases, particularly cancer. The book emphasizes the mechanisms through which natural products operate in treatments, making it a comprehensive guide for understanding their therapeutic potential. Spanning 24 chapters, it delves into regular cancer treatments, challenges faced, and advancements in the field. Special focus is given to phytochemicals and their cellular mechanisms, molecular pathways in therapy, and innovative nano-scale delivery systems that enhance treatment efficacy.This book is an essential resource for oncology researchers, disease therapy experts, diabetes mellitus treatment professionals, cellular signaling scientists, and nanomaterial engineers, offering valuable insights into the clinical applications of phytochemical therapies.

Evaluates the role of natural products in the treatment of diseases, especially cancerProvides details evaluating the role of natural products in regulating cellular and molecular mechanisms in cancer therapyFocuses on the use of nanoparticles for delivery of natural products in disease therapyEncompasses a high number of schematic figures to make it easier for readers to understand conceptsDemonstrates the mechanisms that natural products follow in treatment of diseases, especially cancer therapy

Advances in gastrointestinal cancer therapy: Spotlight on nanoarchitectures considers applications of nanostructures in treatment of gastrointestinal tumors and their capacity in improving efficacy of therapeutics, The book has a strong focus on overcoming challenges in gastrointestinal cancer therapies such as drug resistance, introduction of nanomedicine for drug and gene delivery, and new insight for clinical trials in treatment of patients with gastrointestinal tumors. In 25 chapters Advances in gastrointestinal cancer therapy: Spotlight on nanoarchitectures describes the multiple problems in treatment of gastrointestinal cancers including drug resistance, radio-resistance, inability to reaching to tumor site, degradation of genetic tools by RNase enzymes, and acidic pH of tumor microenvironment that may negatively affect efficacy of chemotherapeutic agents by making changes in their structure. This book is a valuable resource for Students, researchers and academicians in oncology and medical engineering.

Cancer Metabolism: From Molecules to Medicine delivers groundbreaking insights and the latest research into the pivotal role of cancer metabolism in oncology and therapeutic strategies. This book underscores cancer metabolism as a foundational element of cancer biology, predating even the identification of oncogenes and tumor suppressors. It reveals how, unlike normal cells, cancerous cells modify their metabolic pathways to support malignancy, providing new avenues for therapeutic intervention. This book is divided into 16 chapters, delving into the core topics of cancer cell metabolism, metabolic disorders, and autophagy's role in tumor cell metabolism. These subjects illustrate the cellular fitness enhancement via metabolic reprogramming, offering tumors a selective edge through enhanced biosynthesis, altered bioenergetics, and redox balance. This book provides a thorough exploration of how these reprogrammed metabolic processes not only support cancer cell survival and proliferation but also present viable targets for innovative cancer treatments. “Cancer Metabolism: From Molecules to Medicine” serves as an essential resource for scientists and researchers seeking an in-depth understanding of the molecular mechanisms at play in cancer metabolism and its implications for therapy. Additionally, clinicians will find value in the comprehensive coverage of how these metabolic insights translate into novel treatment strategies, bridging the gap between basic research and clinical application. The book's focus on metabolic pathways as therapeutic targets offers practitioners new tools for combating cancer, making it a must-read for both the scientific and medical communities aiming to advance their knowledge and therapeutic capabilities in the dynamic field of cancer metabolism.Delivers comprehensive details on the metabolic transformations distinguishing cancer cells from their normal counterpartsOutlines the latest advancements in anti-cancer drugs that target metabolic processes and signalling pathways, covering both existing and prospective treatmentsExplores the molecular foundations underlying the metabolic regulation of cancer cells, offering deep insights into potential therapeutic targets

"Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications" provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.