Neeraj Mishra - Böcker

Microbiota-Gut-Brain Axis and CNS Disorders: Recent Progress and Perspectives on Human Disease summarizes the main findings on gut-brain axis in different types of CNS disorders, providing a complete overview of the field. The content helps unravel the complex interactions of the microbiota-gut-brain-axis in CNS disorders to pave a better understanding of microbiota-mediated pathogenesis, avenues for noninvasive prognosis, and therapeutic possibilities leveraging microbiota-gut-brain-axis modulations. Coverage includes the role of the microbiota-gut-brain axis and gut virome on human diseases including Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, Depression and Anxiety, Autism Spectrum Disorder, Multiple Sclerosis, Stroke, and others.This book will satisfy the urgent need for a broader view of the current associations between gut microbiota alterations and development of CNS disorders, including the use of novel therapeutic approaches for restoring the correct intestinal bacteria content. It is the perfect reference for translational and clinical gut and microbiome researchers tackling the challenges of delivering genes and drugs in a more targeted and efficient manner for the treatment of CNS disorders.Discusses the development of both health and disease in interdisciplinary research involving gut microbiologyProvides an understanding the role of Microbiome-Gut-Brain axis in neurodegenerative and neurodevelopmental diseases, including central nervous system (CNS) malignanciesDelivers a compilation of current clinical studies to further investigate the role of diet in varying neurological disorders

Emerging Paradigms in Delivery Systems for Antitubercular Therapy provides an up-to-date and thorough overview of the state-of-the-art of concepts, design, and recent advances in nanomedicines and nanobiotechnology-based strategies for the treatment of tuberculosis. The book enables researchers to prepare a variety of nanotechnology-based strategies, investigate their properties, and discover their uses and applications in antitubercular therapy, focusing on advanced nanomaterials that are utilized for encapsulation of nucleic acid, mRNA, DNA, and tuberculosis vaccination.This book covers all major topics that have shaped the development of nanomedicine and propelled it to its current place at the forefront of Nanotechnology based treatment innovation. It will be a welcomed resource for researchers and readers with more and more challenging therapy and biologicals with their possible modifications to be used for the effective therapy of tuberculosis.

Focuses on advanced nanomaterials that are utilized for encapsulation of nucleic acid, mRNA, DNA, and tuberculosis vaccinationCovers all major topics that have shaped the development of nanomedicine and propelled it to its current place at the forefront of nanotechnology based treatment innovationProvides assistance to researchers and readers with more and more challenging therapy and biologicals with their possible modifications to be used for effective therapies in tuberculosis

Liquid biopsy in Cancer Management: Integrating Diagnostics and Clinical Applications provides a comprehensive overview of liquid biopsy, covering its fundamental principles, technological advancements, clinical applications, and future prospects. In 16 chapters, the book focuses both on the practical implications of liquid biopsy in cancer management, and on its role in early detection, treatment monitoring, and personalized therapy. It emphasizes the integration of liquid biopsy into both diagnostic practices and therapeutic strategies, highlighting its potential to transform cancer care. The book discusses the latest research findings and explores future directions in liquid biopsy research, providing readers with a forward-looking view of the field.It includes case studies and examples to illustrate the clinical utility of liquid biopsy and enhance understanding of its applications. Overall, the book aims to be a comprehensive and authoritative resource on the subject, providing readers with a thorough understanding of the current state and future directions of liquid biopsy in cancer management.Empowers clinicians to deliver more personalized and effective cancer care by highlighting the role of liquid biopsy in guiding therapeutic decisionsServes as a valuable resource for those looking to integrate liquid biopsy into their clinical practice or research endeavorsCovers the full spectrum of liquid biopsy applications, from early detection to treatment monitoring and personalized therapy

Nanofiber Therapeutics: Revolutionizing Cancer and Inflammation Management is a comprehensive resource designed to enrich knowledge, catalyze scientific advancements, empower patients, and inform policy decisions in nanomedicine. This book leverages the transformative potential of nanotechnology to combat cancer and inflammation, two of the most challenging health conditions today. The book explores the revolutionary potential of nanofiber-based therapeutics, aiming to develop innovative solutions that overcome existing treatment limitations and improve patient outcomes. It bridges the gap between basic scientific research and clinical application, synthesizing the latest advancements in nanofiber technology with insights from preclinical and clinical studies. Covering every facet of nanofiber therapies-from design and production to clinical applications-the book offers a comprehensive overview. It aims to educate healthcare professionals, researchers, policymakers, patients, and the public about the potential of nanofiber therapeutics, empowering stakeholders with the knowledge needed for informed decision-making and interdisciplinary collaboration. By highlighting cutting-edge research and technological innovations, this book inspires scientific curiosity and further research in the field. It fills a gap in the existing literature, laying the groundwork for future research and development, and driving advancements that could transform cancer and inflammation treatment.Provides a thorough examination of nanofiber therapies, encompassing design, production, and clinical applications in the treatment of inflammation and cancerPresents the most recent developments and studies in nanofiber therapeutics, including novel approaches to drug delivery and advancements in nanofiber technologyOffers insights into how nanofiber technologies can augment existing treatment approaches and improve patient outcomes

Emerging Strategies in Cancer Metabolism: Role of Gut Microbiota, Reactive Oxygen Species, and Short Chain Fatty Acids offers a revolutionary investigation of the complicated relationships between cancer metabolism and three crucial factors: the gut microbiota, reactive oxygen species (ROS), and the dysregulation of the short chain fatty acid (SCF) complex. This book adopts a thorough and interdisciplinary approach to untangle the intricate interactions between these components, providing fresh perspectives that fundamentally alters the understanding of cancer biology and therapy. In 14 chapters.Emerging Strategies in Cancer Metabolism: Role of Gut Microbiota, Reactive Oxygen Species, and Short Chain Fatty Acids provides a thorough investigation of the metabolic changes that occur inside cancer cells, illuminating how these changes promote tumour survival and progression, from introduction to future aspects. Researchers in cancer research, and gut microbiology will find this an essential reference.Creates new opportunities for focused therapies and patient-specific therapy plans by exploring the roles of the gut microbiota, ROS, and SCF dysregulation in cancer metabolismDiscusses in-vitro, ex-vivo, and animal models used to examine the effects of probiotics and their metabolites in cancer careFocuses on cutting-edge research on probiotics and their byproducts treatments in oncogene downregulation, autophagy induction, kinase inhibition, tumour suppressor reactivation, and metastasis prevention

Cellular Therapies for Cancer Treatment: Advancements in Drug Delivery Strategies explores the innovative use of cellular therapy to combat cancer, placing an emphasis on state-of-the-art delivery approaches. By covering a variety of cellular therapies for cancer, such as stem cells, immune cells, and others, this book provides a comprehensive introduction to the field. It describes ways to deliver drugs that target cancer cells more efficiently, decrease off-target effects, and enhance therapy outcomes. Sections provide a brief overview of cancer cell biology, describe the need for advance drug delivery systems, and address challenges and future directions.The book also goes into the ideas behind cellular therapies and how they may overcome drug resistance and make existing cancer treatments more effective. By elaborating on the value of diversity and inclusion in cancer research and treatment, the book also emphasizes the importance of all patients having equal access to innovative therapies. All things considered, this book is a great tool for researchers, doctors, and students in the cancer treatment sector.Gives a comprehensive overview of cellular therapies for cancer treatment, covering basic principles and advanced applicationsProvides access to the latest research advancements, emerging trends, and innovative methodologies in clinical biochemistryOffers real-world case studies and practical insights, illustrating how clinical biochemistry principles are applied in healthcare and research

Inflammation and Cancer: Mechanisms, Diagnosis, and Therapeutic Strategies delves into the intricate relationship between inflammation and cancer, a crucial area of contemporary biomedical research. Sections provide an overview of inflammation's role in cancer, discussing molecular connections and signaling pathways. Chapters explore inflammatory pathways in various cancers, including breast, oral, lung, prostate, skin, and gastrointestinal cancers. The book also covers tumorigenesis, metastasis, preventive strategies, inflammatory biomarkers for cancer diagnosis, and innovative therapeutic designs. Final chapters focus on the dual role of platelets, targeting tumor-associated macrophages, novel treatment approaches, and recent advances in the field.This title offers substantial benefits to researchers, clinicians, and healthcare professionals by providing a thorough understanding of the cellular and molecular pathways linking inflammation and cancer, aiding in the development of effective anti-cancer immunotherapies. By highlighting the latest research and potential therapeutic strategies, this book serves as an essential resource for anyone dedicated to combating cancer through innovative and informed immunotherapeutic approaches.Explores the intricate relationship between inflammation and cancer, tumor initiation, and progressionProvides a comprehensive analyses of inflammatory pathways in various cancersOffers insights into molecular mechanisms and the inflammatory signaling pathways crucial for developing effective anti-cancer therapiesHighlights innovative immunotherapeutic strategies and preventive measures to more effectively target cancerConveys the latest research advancements and future directions in cancer-related inflammation studies

Nano Drug Delivery for Colon Cancer: Innovations, Challenges, and Applications is a breakthrough exploration that delves into the latest advancements in colon cancer diagnosis and treatment. This comprehensive guide, composed of 11 detailed chapters, focuses on the design, synthesis, and application of various nanodrug delivery systems, showcasing how nanoparticulate drug carriers can significantly enhance therapeutic efficacy through strategic design. Aimed at graduates, clinical researchers, and scientists, this book addresses the complexities and challenges in drug and gene delivery. Beyond its technical insights, the book highlights the global health impact of colon cancer and offers a roadmap for developing more efficient and targeted treatments.It serves as a vital resource, fostering interdisciplinary knowledge and advancements that have the potential to revolutionize colon cancer therapeutics. The book's interdisciplinary approach ensures it is a beacon of knowledge for those seeking to navigate and innovate within this critical field.Delivers an in-depth exploration of the design, synthesis, and application of nanodrug delivery systemsUnveils groundbreaking and state-of-the-art approaches in colon cancer diagnosis and treatment, placing readers at the cutting edge of medical innovationShowcases how strategic design methodologies can dramatically boost therapeutic efficacy, paving the way for more effective colon cancer treatments

Mitochondria-targeted Drug Delivery Strategies for Cancer Therapy explores the innovative use of biocompatible, multifunctional nanoplatforms to target mitochondria for selective drug delivery, enhancing treatment efficacy while minimizing side effects. The book provides a comprehensive overview of the role of nanotechnology in cancer treatment, reviewing the basics of nanotechnology and cancer biology, advanced nanoengineering strategies, and the development of mitochondria-targeted drug delivery systems, such as liposomal therapies, photosensitizer nanoparticles, and peptides for cancer treatment, along with strategies to modulate mitochondrial functions using nanomaterials.This is a valuable resource to researchers and scientists interested in the application of nanotechnology for improved cancer therapy as it provides a thorough overview of real-world applications and future research trends as well as a discussion on overcoming challenges in mitochondrial targeting.Reviews the principles of mitochondria-targeted drug delivery, including the design of nanocarriers, mechanisms of mitochondrial targeting, and methods for evaluating delivery efficiencyIncludes case studies and examples from recent research to illustrate the application of nanotechnology in targeting mitochondria for cancer treatmentDiscusses future research directions in the field, including emerging trends and technologies that may further advance mitochondria-targeted drug delivery for cancer treatment

Signaling Pathways in Breast Cancer: Molecular Mechanisms, Therapeutic Strategies, and Multidrug Resistance provides an in-depth exploration of the complex molecular mechanisms that drive breast cancer progression. The book focuses on critical signaling pathways, including PI3K/Akt/mTOR, MAPK/ERK, JAK/STAT, Wnt/?-catenin, and Notch, elucidating their roles in tumor development, survival, and therapeutic resistance. The content offers a comprehensive overview of these pathways, detailing their dysregulation in breast cancer and implications for targeted therapeutic strategies. It discusses FDA-approved treatments, emerging therapies, and the mechanisms behind drug resistance, integrating recent research findings to highlight novel molecular targets and biomarker discovery. This book serves as a valuable resource for researchers, clinicians, and students, bridging the gap between basic molecular biology and clinical applications. By providing structured insights into complex signaling networks and therapeutic interventions, it equips readers with essential knowledge for developing innovative approaches to breast cancer management and improving patient outcomes.Provides a detailed exploration of critical signaling pathways such as PI3K/Akt, MAPK, JAK/STAT, and Notch, elucidating their roles in tumor initiation, progression, and resistance to therapyDiscusses FDA-approved targeted therapies and emerging treatment strategies, including immunotherapy and personalized medicineAddresses mechanisms of drug resistance and potential strategies for overcoming resistanceIncludes case studies and biomarker-based approaches that link molecular mechanisms to clinical outcomesOffers insights into ongoing clinical trials and future directions in breast cancer therapy

Metallic Nanoparticles in Cancer Therapy explores the innovative use of metallic nanoparticles in cancer therapy. It investigates the production, functionalization, and medicinal uses of metallic nanoparticles, including iron oxide, gold, and silver, emphasizing their potential for targeted drug administration, imaging, and therapy. It also tackles essential regulatory and safety considerations, connecting research with clinical application.Features:Covers specifics to the theranostic application of metallic nanoparticles for cancer treatmentDescribes therapeutic strategies of nanoparticles in drug administration routes and targeting mechanismsGives insight into phytochemical and biogenic surface-modified metal nanoparticlesDiscusses bioavailability and toxicity assessment of metallic nanoparticlesThis book is aimed at researchers in metallic nanoparticle and physicians and regulatory professionals in nanotechnology for precision oncology.

This book explores the potential role of prebiotics, probiotics, and synbiotics in managing various metabolic disorders, chronic diseases, and metabolic syndromes. The initial chapter provides an overview of metabolic disorders, including their classification, symptoms, and underlying causes. Additionally, the chapter discusses the intricate signaling pathways and mechanisms through which prebiotics, probiotics, and synbiotics interact with the human body in relation to type-2 diabetes, obesity, Phenylketonuria, and Hemochromatosis. Additionally, the book highlights the potential impact of probiotics and synbiotics on oxidative stress, inflammation, lipid metabolism, and blood pressure. Furthermore, this book focuses on the gut-brain axis and how synbiotics may influence neurotransmitter metabolism. With an emphasis on the gut-microbiota axis, this book presents a compelling narrative that explores the rationality behind synbiotic use and offers a glimpse into future perspectives for managing metabolic disorders effectively. This book is intended for researchers in the fields of nutraceuticals, nanomedicine, endocrinology, nutrition, gastroenterology, and metabolic medicine who are working in the field of probiotics, prebiotics, and symbiotics for the treatment of metabolic disorders.

This book offers a comprehensive and multi-faceted examination of gastrointestinal inflammations, discussing factors that impact gut health. The initial chapters establish a foundational understanding of gastrointestinal inflammations and the critical role of the gut microbiota. The book then delves into the complex pathophysiology and various risk factors associated with these conditions, offering insights into the latest diagnostic, screening, and prevention techniques. It explores the dynamic interactions between the gut and the brain as well as the biochemical interplays involving short-chain fatty acids, reactive oxygen species, and superoxide dismutases. Additionally, the book thoroughly discusses the impact of genetics on gastrointestinal health, the interactions between antibiotics and gut microbiota, and the pivotal role of the immune system in inflammation. It highlights advancements in diagnostic technologies and gut microbiota-based strategies, along with the use of nanoparticles in treatment. The book also examines the psychological aspects associated with gastrointestinal inflammations, emphasizing the importance of mental health for physical well-being. It assesses the potential of functional foods, various types of nanocarriers, and plant-based bioactives in managing gastrointestinal inflammations. As such, this book is primarily intended for researchers and students in the fields of gastroenterology and microbiology.Key Features:Provides an extensive overview of gastrointestinal inflammations, starting from the basic concepts of the gut microbiota to complex pathophysiological aspectsDelves into the latest advancements in diagnostic, screening, and prevention techniques, highlighting cutting-edge technologies and approaches in gastroenterologyExplores the role of the immune system and the impact of genetics and diet on gastrointestinal healthExamines use of probiotics, prebiotics, postbiotics, and various nanotechnology-based approaches for gastrointestinal inflammation managementEmphasis on the psychological factors associated with gastrointestinal inflammations

This book presents the evolution, challenges, and opportunities in the field of drug delivery. From foundational concepts to cutting-edge technologies, each chapter of Novel Drug Delivery Approaches: From Fundamentals to Advanced Carrier Systems delves into critical aspects that shape the landscape of drug delivery systems. It highlights the crucial role of translational research in bridging the gap between scientific discoveries and clinical applications. Subsequent chapters explore the diverse materials and technologies driving advancements in drug delivery, ranging from polymers and nanoparticles to colonic and intracellular delivery systems. Special emphasis is placed on specific applications and systems, including the role of metallic nanoparticles and nucleic acid-based therapeutic delivery systems. Emerging areas such as nasopulmonary and ocular drug delivery systems are thoroughly examined, uncovering challenges and opportunities in these specialized fields. Additionally, this book addresses the complexities of targeted carrier-based intracellular drug delivery, aiming to enhance treatment efficacy while minimizing toxicity. It provides insights into innovative approaches and challenges in brain drug delivery, transdermal drug therapy, and delivery systems for combating viral infections. Furthermore, this book delves into critical aspects of scaling, efficacy, safety, and regulatory considerations.This book caters to researchers in biomedical sciences, pharmaceutical sciences, and biotechnology.Key FeaturesOffers an extensive examination of drug delivery, spanning foundational concepts to the latest advancementsProvides insights into a diverse array of materials and technologies driving drug delivery advancementsExplores insights into potential future trends and innovations of nasopulmonary and ocular drug delivery systemsHighlights colonic drug delivery for gastrointestinal treatments and the use of nanoparticles for intracellular deliveryDiscusses quality by design (QbD) approaches in designing novel drug delivery systems and the scale-up technologies for nanomedicine

This book reviews the pivotal role of prebiotics, probiotics, and postbiotics in modulating the gut–brain axis, offering insights into their potential therapeutic applications and impact on neurological health. The initial chapters provide a foundational overview of prebiotics and introduce readers to the concept of the gut–brain axis. These chapters discuss bidirectional communication within the gut–brain axis and the impacts of gut dysbiosis on neurological health. Further chapters investigate the relationship between the gut–brain axis and autoimmune diseases, as well as the role of probiotics in major neurodegenerative diseases such as Alzheimer’s and Parkinson’s, amyotrophic lateral sclerosis (ALS), Huntington’s disease, and conditions like multiple sclerosis (MS), epilepsy, and seizures. The book also examines the influence of prebiotics on mental health disorders such as anxiety and depression, and their impact on ischemic stroke via the gut–brain axis. It further covers the role of probiotics in reactive oxygen species (ROS) and inflammation-mediated neurodegenerative diseases and explores the correlation between gut microbiota, malnutrition, and neurological disorders. The book explores signaling pathways within the gut–brain axis and their relationships with neurological disorders, the application of prebiotics as functional foods, and the therapeutic potential of postbiotics and psychobiotics. This book is intended for scientists and researchers in the fields of microbiology, neuroscience, and gastroenterology. The book:Provides a thorough understanding of prebiotics, probiotics, and postbiotics, and their roles in the gut–brain axisExplores bidirectional communication within the gut–brain axis and its impact on neurological healthExamines the relationship between the gut microbiota and various neurological disordersDiscusses the influence of prebiotics and probiotics on mental health disorders such as anxiety and depressionInvestigates the connection between the gut–brain axis and autoimmune diseasesCovers advanced tools and bioinformatics approaches for studying gut microbiota and neurodegeneration

This book provides concepts, procedures, guidelines, and regulatory affairs in drug development. Pharmaceutical Regulatory Affairs: Principles and Practices begins with a detailed overview of the drug development life cycle, from initial discovery and preclinical research to clinical trials and market approval, addressing scientific, regulatory, and ethical considerations at each stage. The book covers the evolution of global trade agreements like the General Agreement on Tariff and Trades (GATT) and the World Trade Organization’s (WTO) impact on pharmaceuticals, highlighting issues surrounding pharmaceutical patents and intellectual property rights. It discusses the importance of the Scale-Up and Post-Approval Changes (SUPAC) guidelines in ensuring quality and consistency in drug manufacturing post-approval and examines the World Health Organization's (WHO) guidelines on technology development and transfer. The fundamentals of regulatory affairs are covered, emphasizing the roles and responsibilities of regulatory professionals. The book provides an in-depth look at regulatory frameworks of major agencies worldwide, including the Central Drugs Standard Control Organization (CDSCO) in India, the Food and Drug Administration (FDA) in the US, the European Medicines Agency (EMA) in the EU, the Therapeutic Goods Administration (TGA) in Australia, the Pharmaceuticals and Medical Devices Agency (PMDA) in Japan, Health Canada, and regulatory authorities in emerging markets. It also addresses the international regulatory landscape for medical devices and reviews foundational pharmaceutical regulations. Additionally, the text explores regulatory guidelines for clinical testing, including the roles and responsibilities under pharmaceutical legislation, principles of bioethics and biosafety, the digital transformation in clinical trials, and the critical role of pharmacovigilance. The book concludes with an examination of the global regulatory scenario for pharmaceutical excipients, providing a detailed roadmap through the complexities of drug development, regulatory compliance, and global standards. This book is valuable for professionals, researchers, and students of pharmaceutical sciences.

This comprehensive volume covers the entire field of flavonoids by explaining their complex functions in reducing chronic metabolic illnesses, from the early stages of laboratory research to the development of therapeutic uses. Flavonoids are plant-based substances proven to have potential medical benefits in managing chronic metabolic disorders. This book explores concepts in laboratory research and therapeutic capabilities to enhance awareness of flavonoids in a medical context. The book begins with a thorough examination of the basic biochemical and molecular processes that underlie long-term metabolic disorders. It looks into these bioactive substances, from their natural origins to the synthesis of innovative derivatives. Analyzing both lab research and preclinical trials critically, it provides a solid basis for understanding the exciting opportunities flavonoids bring in treating metabolic diseases. The scope of this work extends beyond theoretical domains into clinical environments. It closes the gap between bench-side findings and bedside applications by revealing the translational potential of flavonoids. It is possible to understand the practical implications and future directions of flavonoid-based therapeutics through the synthesis of evidence-based clinical studies, therapeutic approaches, and possible healthcare issues. Readers will find the book: contains cutting-edge insights into metabolic disease research and delves into recent discoveries on the molecular mechanisms of flavonoids; facilitates a viewpoint into the findings of practical clinical implementations and the progression of flavonoid investigations from controlled experimental environments to prospective therapeutic interventions;explores the scientific effects of flavonoids on chronic metabolic disorders;presents evidence from human trials and epidemiological research on flavonoid clinical processes;encompasses various aspects of preventive measures for managing widespread metabolic diseases, containing dietary recommendations, lifestyle interventions, and the potential involvement of flavonoids;offers a comprehensive guide on how to effectively utilize flavonoids for therapeutic purposes. Audience This book is intended for researchers, scientists, clinicians/physicians, and public health professionals who work in pharmacology settings. The book is a vital tool for clinicians, nutritionists, and other healthcare professionals who are concerned about cutting-edge methods for dietary guidelines to gain an understanding of flavonoids and long-term metabolic disorders.

This new volume delves into the extensive new research on inflammatory bowel disease (IBD) and gut microbiota that has led to effective therapeutic interventions. Highlighting novel methodologies and innovative treatment approaches, the book provides a comprehensive investigation of IBD, exploring the significance of gut microbiota and investigating the fundamental role of microbial imbalances in the initiation and progression of inflammatory processes as well as the prominent therapeutic consequences of restoring microbial homeostasis. From nanoparticle-based drug delivery systems that advance the bioavailability of the medicament to the use of bio-nanosensors for early detection of disease, the book covers a broad spectrum of inventions that hold potential for revolutionizing IBD treatment. The authors look at the impact of nutraceuticals, probiotics, prebiotics, functional foods, oral siRNA-based nanomedicine, and other novel drug delivery systems on gut microbiota for the management of IBD. The book also explores the role of reactive oxygen species (ROSs), superoxide dismutases (SODs), and inflammation in association with gut microbiota and IBD.

Silk represents an excellent source of natural biomaterials, and silk-based biopolymers have been used in numerous drug delivery applications. Silk has a proven track record in biomedicine owing to its superior compatibility with the human body, its superb mechanical characteristics, and its controllable propensity to decay. Due to its robust biocompatibility and its less immunogenic, non-toxic, non-carcinogenic, and biodegradable properties, silk has been widely used in biological and biomedical fields, proving to be a more efficient manner for the treatment of various diseases.This book presents a comprehensive review of silk-based biopolymer drug delivery systems, providing an introduction and going on to detail the chemistry, collection, characterization, functionalization, and numerous silk-based applications in the pharmaceutical industry and healthcare fields. It discusses its uses for oral drug delivery, for vaccine delivery systems, as natural mucoadhesive polymers for controlled drug delivery, for wound healing, etc.Exploring the many promising applications of silk-based proteins in the field of drugs and gene delivery and biomedical applications, the book emphasizes recent advancements made by academicians, researchers, and industry and regulatory scientists. It provides methodologies for the design, development, and selection of silk-based proteins in drug delivery for therapeutic applications.

While a combination of autophagy inhibitor and cytotoxic medicines is now being used in cancer treatment, investigating the potential of autophagy inhibitors for overcoming resistance to different anticancer medications and how this relates to the control of cancer micro environmental stressors raises several questions.

Autophagy is a catabolic process that eliminates damaged and faulty cellular components via lysosomes. It responds to adverse circumstances like nutritional deficiency, hypoxia, and oxidative damage. Reactive oxygen species (ROS) cause oxidative stress, which is a multidimensional chemical that drives various pathophysiological diseases, including cancer. In addition, the autophagy process has a double role, first preventing tumour formation, but later fostering tumour progression. A growing body of research suggests that autophagy and ROS have a complex interplay in which they can either prevent cancer growth or enhance disease genesis. While a combination of autophagy inhibitor and cytotoxic medicines is now being used in cancer treatment, investigating the potential of autophagy inhibitors for overcoming resistance to different anticancer medications and how this relates to the control of cancer micro environmental stressors raises several questions. Autophagy's dual functions as a safeguarding and cytotoxic process have drawn attention to its significance in the development of cancer.

The emerging role of gut microbiota and postbiotics has implications for the management of not only human health and diseases, but also colorectal cancer in particular, as these elements influence colorectal cancer pathogenesis, treatment, and prevention.

This book offers a wide perspective on the fundamental and state-of-the-art knowledge in radiobiology, radiation oncology, and the connection between both fields. Chapters incorporate basic concepts of cancer biology and radiobiology with advances in radiotherapy in cancer treatment for various types of cancer. Chapters review one or more areas of radiation oncology with topics ranging from the application of radiotherapy in various cancers, the use of advanced techniques such as FLASH radiotherapy, applications of artificial intelligence in treatment planning, and more importantly, the current and potential strategies to reduce the toxic effects of radiation. This book incorporates interdisciplinary concepts by exploring recent approaches like radiogenomics for personalizing radiotherapy and the effects of the microbiome on radiation research.Teaching the basics of radiobiology and connections between the theory and the practical aspects of radiotherapy techniques, this book is a useful reference for cancer researchers, practitioners, interdisciplinary researchers in related fields, and students in radiation oncology and radiobiology. Through this integration of strong scientific foundations and clinical applicability, this book provides future research directions and rationales for readers looking to expand their knowledge about radiation with the most recent and essential data on the subject.

Reactive oxygen species (ROS)-mediated inflammation plays a critical role in the onset and progression of various metabolic disorders, including obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD). Dysregulated ROS production leads to oxidative stress, which triggers chronic low-grade inflammation, disrupting cellular homeostasis and metabolic functions. This pathological interplay exacerbates insulin resistance, lipid accumulation, and mitochondrial dysfunction, creating a vicious cycle of metabolic dysregulation. Understanding the molecular mechanisms behind ROS-mediated inflammation is crucial for developing targeted therapeutic interventions to break this cycle and mitigate disease progression.This comprehensive book bridges the gap between fundamental molecular insights and translational therapeutic strategies. It begins by delving into the signaling pathways involved, such as NF-κB and Nrf2, and highlighting the role of key players like mitochondria and antioxidant systems. Later chapters explore emerging therapeutic approaches, including postbiotics, natural antioxidants, and pharmacological agents, offering practical solutions for managing metabolic disorders. By addressing this critical intersection of inflammation, oxidative stress, and metabolism, this book is a valuable guide for researchers, clinicians, and healthcare professionals who aim to tackle the global burden of metabolic diseases effectively.

The up-to-date chapters provide recent information about the effect of anticancer treatment approaches on gut microbiota, the correlation between ROS and synbiotics for effective cancer treatment, and the influence of synbiotics on inflammation and immune microenvironment for cancer treatment.

The up-to-date chapters provide recent information about the effect of anticancer treatment approaches on gut microbiota, the correlation between ROS and synbiotics for effective cancer treatment, and the influence of synbiotics on inflammation and immune microenvironment for cancer treatment.