Sumel Ashique – författare

Mitochondria and Cancer: From Basic Science to Clinical Applications-Understanding Pathogenesis, Therapy Resistance, and Disease Relapse offers comprehensive perspectives about the role of mitochondria in cancer biology and treatment. This book integrates fundamental scientific knowledge with clinical relevance, presenting recent findings that will engage oncology researchers and provide valuable recommendations for cancer prevention and prognosis. In response to the rising global cancer incidence, this book serves as a comprehensive guide to mitochondrial metabolism in oncology, furthering cancer study and management. It explores a wide range of topics that highlight the multifaceted role of mitochondria in cancer, including tumor microenvironment, cancer stem cells, microbiota, resistance mechanisms, mitochondria-enhancing strategies, and targeted therapies. It includes technical details, research findings, and discussions on the implications of mitochondrial research in cancer treatment and management. Its distinguishing aspects include its comprehensive coverage and diverse perspectives from global experts, providing a well-rounded view of current research.Delivers an in-depth analysis of how mitochondrial alterations contribute to cancer formation, disease progression, and resistance to conventional and targeted therapiesPresents comprehensive insights into the dynamic interactions between mitochondria in cancer cells, tumor microenvironment, and microbiota, highlighting their collective influence on cancer progression and therapeutic outcomesCombines fundamental scientific knowledge with clinical relevance, covering a wide array of topics from mitochondrial metabolism to innovative therapeutic strategies

Unlocking Sirtuins: Cellular Biology to Translational Research explores the intricate roles of sirtuins, from basic principles to clinical significance. The book is organized into six parts, covering foundational concepts, roles in aging and metabolism, disease pathology, therapeutic strategies, future research directions, and potential challenges. Topics include the structure and evolution of sirtuins, their mechanisms of action, and their impact on neurodegenerative diseases, cardiovascular health, and cancer. The book also features detailed chapters on sirtuin modulators, drug discovery, the latest technologies and tools in the field, emerging trends, and the challenges, ethical considerations and future directions of sirtuin-targeted therapies.The book's content is complemented by case studies, clinical insights, and step-by-step procedures, offering a comprehensive and practical exploration of the subject. Users will find an in-depth overview of sirtuin biology, bridging fundamental science with clinical applications. This comprehensive resource will serve as an essential resource for researchers, clinicians, and advanced students working across cellular and molecular biology, biochemistry, pharmacology, aging, metabolic disorders, translational medicine, and related fields.Provides an interdisciplinary overview of sirtuin biology, bridging foundational science with translational researchFacilitates the development of sirtuin-targeted therapies for a variety of diseases, including cancer and neurodegenerative disordersHighlights cutting-edge tools and technologies for sirtuin analysisIncludes case studies and step-by-step procedures to support scientists in their own research

Signaling Pathways in Breast Cancer: Molecular Mechanisms, Therapeutic Strategies, and Multidrug Resistance provides an in-depth exploration of the complex molecular mechanisms that drive breast cancer progression. The book focuses on critical signaling pathways, including PI3K/Akt/mTOR, MAPK/ERK, JAK/STAT, Wnt/?-catenin, and Notch, elucidating their roles in tumor development, survival, and therapeutic resistance. The content offers a comprehensive overview of these pathways, detailing their dysregulation in breast cancer and implications for targeted therapeutic strategies. It discusses FDA-approved treatments, emerging therapies, and the mechanisms behind drug resistance, integrating recent research findings to highlight novel molecular targets and biomarker discovery. This book serves as a valuable resource for researchers, clinicians, and students, bridging the gap between basic molecular biology and clinical applications. By providing structured insights into complex signaling networks and therapeutic interventions, it equips readers with essential knowledge for developing innovative approaches to breast cancer management and improving patient outcomes.Provides a detailed exploration of critical signaling pathways such as PI3K/Akt, MAPK, JAK/STAT, and Notch, elucidating their roles in tumor initiation, progression, and resistance to therapyDiscusses FDA-approved targeted therapies and emerging treatment strategies, including immunotherapy and personalized medicineAddresses mechanisms of drug resistance and potential strategies for overcoming resistanceIncludes case studies and biomarker-based approaches that link molecular mechanisms to clinical outcomesOffers insights into ongoing clinical trials and future directions in breast cancer therapy

This book explores the potential role of prebiotics, probiotics, and synbiotics in managing various metabolic disorders, chronic diseases, and metabolic syndromes. The initial chapter provides an overview of metabolic disorders, including their classification, symptoms, and underlying causes. Additionally, the chapter discusses the intricate signaling pathways and mechanisms through which prebiotics, probiotics, and synbiotics interact with the human body in relation to type-2 diabetes, obesity, Phenylketonuria, and Hemochromatosis. Additionally, the book highlights the potential impact of probiotics and synbiotics on oxidative stress, inflammation, lipid metabolism, and blood pressure. Furthermore, this book focuses on the gut-brain axis and how synbiotics may influence neurotransmitter metabolism. With an emphasis on the gut-microbiota axis, this book presents a compelling narrative that explores the rationality behind synbiotic use and offers a glimpse into future perspectives for managing metabolic disorders effectively. This book is intended for researchers in the fields of nutraceuticals, nanomedicine, endocrinology, nutrition, gastroenterology, and metabolic medicine who are working in the field of probiotics, prebiotics, and symbiotics for the treatment of metabolic disorders.

This book offers a comprehensive and multi-faceted examination of gastrointestinal inflammations, discussing factors that impact gut health. The initial chapters establish a foundational understanding of gastrointestinal inflammations and the critical role of the gut microbiota. The book then delves into the complex pathophysiology and various risk factors associated with these conditions, offering insights into the latest diagnostic, screening, and prevention techniques. It explores the dynamic interactions between the gut and the brain as well as the biochemical interplays involving short-chain fatty acids, reactive oxygen species, and superoxide dismutases. Additionally, the book thoroughly discusses the impact of genetics on gastrointestinal health, the interactions between antibiotics and gut microbiota, and the pivotal role of the immune system in inflammation. It highlights advancements in diagnostic technologies and gut microbiota-based strategies, along with the use of nanoparticles in treatment. The book also examines the psychological aspects associated with gastrointestinal inflammations, emphasizing the importance of mental health for physical well-being. It assesses the potential of functional foods, various types of nanocarriers, and plant-based bioactives in managing gastrointestinal inflammations. As such, this book is primarily intended for researchers and students in the fields of gastroenterology and microbiology.Key Features:Provides an extensive overview of gastrointestinal inflammations, starting from the basic concepts of the gut microbiota to complex pathophysiological aspectsDelves into the latest advancements in diagnostic, screening, and prevention techniques, highlighting cutting-edge technologies and approaches in gastroenterologyExplores the role of the immune system and the impact of genetics and diet on gastrointestinal healthExamines use of probiotics, prebiotics, postbiotics, and various nanotechnology-based approaches for gastrointestinal inflammation managementEmphasis on the psychological factors associated with gastrointestinal inflammations

This book provides a comprehensive examination of wound healing, starting with the foundational knowledge, including the factors affecting it, and the principles guiding wound healing. It delves into the molecular underpinnings of wound healing, particularly in the context of diabetes, and discusses the challenges of chronic wound healing, including the limitations of existing treatments. It explores the current status and future prospects of nanomaterials, including innovative approaches such as smart 3D printed hydrogels, drug-loaded nanomaterials, and natural bioactive compounds encapsulated within nanomaterials. The book also introduces bio-inspired nanomaterials and their application in wound dressings and tissue regeneration, emphasizing the diagnostic-to-therapeutic strategy continuum. Further chapters cover the specific roles of nano-biomaterials in diabetic wound healing, skin tissue engineering, and the antibacterial properties of nanomaterials that promote wound healing. It looks into engineered nanomaterials, green synthesized nanomaterials for wound healing and cell growth stimulation, and the advanced application of nanocellulose. The role of the immune system in wound healing and strategies for modulating immune responses to enhance healing processes are explored. Lastly, the book addresses the mechanisms of nanomaterials in wound healing, their recent advancements, limitations, future perspectives, and the importance of conducting toxicity studies on nanomaterials used for wound healing. This book is an invaluable resource for researchers, clinical practitioners, and students of biomedical engineering, human physiology, and nanotechnology.Key Features:Offers a thorough exploration of wound healing processes, starting from basic principles to advanced molecular insightsPresents the use of nanomaterials in wound healing, including smart 3D printed hydrogels, drug-loaded nanomaterials, and bioactive compoundsAddresses the challenges associated with chronic wound healing, especially in the context of diabetesIntroduces bio-inspired nanomaterials and their application in wound dressings and tissue regeneration.Examines the role of the immune system in wound healing and discusses strategies to modulate immune responses

This book reviews the pivotal role of prebiotics, probiotics, and postbiotics in modulating the gut–brain axis, offering insights into their potential therapeutic applications and impact on neurological health. The initial chapters provide a foundational overview of prebiotics and introduce readers to the concept of the gut–brain axis. These chapters discuss bidirectional communication within the gut–brain axis and the impacts of gut dysbiosis on neurological health. Further chapters investigate the relationship between the gut–brain axis and autoimmune diseases, as well as the role of probiotics in major neurodegenerative diseases such as Alzheimer’s and Parkinson’s, amyotrophic lateral sclerosis (ALS), Huntington’s disease, and conditions like multiple sclerosis (MS), epilepsy, and seizures. The book also examines the influence of prebiotics on mental health disorders such as anxiety and depression, and their impact on ischemic stroke via the gut–brain axis. It further covers the role of probiotics in reactive oxygen species (ROS) and inflammation-mediated neurodegenerative diseases and explores the correlation between gut microbiota, malnutrition, and neurological disorders. The book explores signaling pathways within the gut–brain axis and their relationships with neurological disorders, the application of prebiotics as functional foods, and the therapeutic potential of postbiotics and psychobiotics. This book is intended for scientists and researchers in the fields of microbiology, neuroscience, and gastroenterology. The book:Provides a thorough understanding of prebiotics, probiotics, and postbiotics, and their roles in the gut–brain axisExplores bidirectional communication within the gut–brain axis and its impact on neurological healthExamines the relationship between the gut microbiota and various neurological disordersDiscusses the influence of prebiotics and probiotics on mental health disorders such as anxiety and depressionInvestigates the connection between the gut–brain axis and autoimmune diseasesCovers advanced tools and bioinformatics approaches for studying gut microbiota and neurodegeneration

This book provides concepts, procedures, guidelines, and regulatory affairs in drug development. Pharmaceutical Regulatory Affairs: Principles and Practices begins with a detailed overview of the drug development life cycle, from initial discovery and preclinical research to clinical trials and market approval, addressing scientific, regulatory, and ethical considerations at each stage. The book covers the evolution of global trade agreements like the General Agreement on Tariff and Trades (GATT) and the World Trade Organization’s (WTO) impact on pharmaceuticals, highlighting issues surrounding pharmaceutical patents and intellectual property rights. It discusses the importance of the Scale-Up and Post-Approval Changes (SUPAC) guidelines in ensuring quality and consistency in drug manufacturing post-approval and examines the World Health Organization's (WHO) guidelines on technology development and transfer. The fundamentals of regulatory affairs are covered, emphasizing the roles and responsibilities of regulatory professionals. The book provides an in-depth look at regulatory frameworks of major agencies worldwide, including the Central Drugs Standard Control Organization (CDSCO) in India, the Food and Drug Administration (FDA) in the US, the European Medicines Agency (EMA) in the EU, the Therapeutic Goods Administration (TGA) in Australia, the Pharmaceuticals and Medical Devices Agency (PMDA) in Japan, Health Canada, and regulatory authorities in emerging markets. It also addresses the international regulatory landscape for medical devices and reviews foundational pharmaceutical regulations. Additionally, the text explores regulatory guidelines for clinical testing, including the roles and responsibilities under pharmaceutical legislation, principles of bioethics and biosafety, the digital transformation in clinical trials, and the critical role of pharmacovigilance. The book concludes with an examination of the global regulatory scenario for pharmaceutical excipients, providing a detailed roadmap through the complexities of drug development, regulatory compliance, and global standards. This book is valuable for professionals, researchers, and students of pharmaceutical sciences.

This book comprehensively reviews the role of engineered nanomaterials in wound healing. It presents green synthesized nanomaterials for wound healing and cell growth stimulation and explores the advanced application of nanocellulose. The book highlights innovative approaches like smart 3D printed hydrogels and drug-loaded nanomaterials, as well as natural bioactive compounds encapsulated within nanomaterials. It also covers advancements in nanomaterial-based drug delivery systems and the integration of artificial intelligence in wound healing. Further chapters discuss the role of the immune system and the extracellular matrix in wound healing, strategies to modulate immune responses, and recent advancements in tissue engineering. The book addresses the mechanisms, limitations, and future perspectives of nanomaterials in wound healing, and emphasizes the importance of toxicity studies.

This book discusses the role of postbiotics in human health. The initial chapter highlights the potential of postbiotics beyond traditional prebiotics and probiotics. Subsequent chapters present the beneficial effects on various health conditions, including cardiovascular disorders, cancer, diabetes, gestational diabetes, obesity, and mitochondrial disorders.The book covers the role of postbiotics in immune system modulation and inflammation-mediated metabolic disorders. It also explores the interaction of postbiotics with gut microbiota, detailing molecular mechanisms and signaling pathways. In addition, it offers current and future perspectives on postbiotics in human health, addressing their role in managing insulin resistance, glucose metabolism, metabolic endotoxemia, and inflammation in type 2 diabetes. The text provides an in-depth analysis of the impact of postbiotics on non-alcoholic fatty liver disease (NAFLD), lipid profiles, and hypertension. In addition, the chapters:1) Explore the promising concept of postbiotics and their potential beyond prebiotics and probiotics.2) Examine the beneficial effects of postbiotics on cardiovascular health, cancer, diabetes, and other conditions.3) Discuss the role of postbiotics in immune system modulation and inflammation-mediated metabolic disorders.4) Cover the interaction of postbiotics with gut microbiota, highlighting molecular mechanisms and signaling pathways.5) Analyze the current and future perspectives on postbiotics, including their impact on various metabolic disorders.This book is a useful resource for researchers and students of pharmacology and biotechnology.

This book provides a comprehensive review of the emerging role of extrachromosomal DNA (ecDNA) in cancer, highlighting its significance in tumor progression, oncogene amplification, drug resistance, and clinical applications. Extrachromosomal DNA in Cancer: Mechanisms, Biomarkers, and Therapeutic Implications explores the structural and functional characteristics of ecDNA, emphasizing its role in shaping the genetic and epigenetic landscapes of cancer cells. The book discusses the impact of ecDNA on tumor heterogeneity, metastasis, and immune evasion, providing insights into how ecDNA contributes to cancer evolution and therapeutic resistance. The text also examines cutting-edge imaging techniques, computational approaches, and non-invasive diagnostic applications of ecDNA, highlighting its potential as a biomarker in precision oncology. Additionally, it presents the novel therapeutic strategies targeting ecDNA, addressing challenges and opportunities in integrating these insights into cancer treatment.FeaturesExplores the structural formation and oncogenic role of ecDNA in tumor development and progressionDiscusses the influence of ecDNA on gene expression, epigenetics, and immune modulation in cancerExamines the role of ecDNA in drug resistance, metastasis, and disease recurrenceHighlights advanced imaging, computational tools, and non-invasive diagnostic applications of ecDNAReviews emerging therapeutic strategies targeting ecDNA for improved cancer treatment and personalized medicine This book is intended for researchers and students of cancer biology, molecular biology, and biotechnology.

This comprehensive volume covers the entire field of flavonoids by explaining their complex functions in reducing chronic metabolic illnesses, from the early stages of laboratory research to the development of therapeutic uses. Flavonoids are plant-based substances proven to have potential medical benefits in managing chronic metabolic disorders. This book explores concepts in laboratory research and therapeutic capabilities to enhance awareness of flavonoids in a medical context. The book begins with a thorough examination of the basic biochemical and molecular processes that underlie long-term metabolic disorders. It looks into these bioactive substances, from their natural origins to the synthesis of innovative derivatives. Analyzing both lab research and preclinical trials critically, it provides a solid basis for understanding the exciting opportunities flavonoids bring in treating metabolic diseases. The scope of this work extends beyond theoretical domains into clinical environments. It closes the gap between bench-side findings and bedside applications by revealing the translational potential of flavonoids. It is possible to understand the practical implications and future directions of flavonoid-based therapeutics through the synthesis of evidence-based clinical studies, therapeutic approaches, and possible healthcare issues. Readers will find the book: contains cutting-edge insights into metabolic disease research and delves into recent discoveries on the molecular mechanisms of flavonoids; facilitates a viewpoint into the findings of practical clinical implementations and the progression of flavonoid investigations from controlled experimental environments to prospective therapeutic interventions;explores the scientific effects of flavonoids on chronic metabolic disorders;presents evidence from human trials and epidemiological research on flavonoid clinical processes;encompasses various aspects of preventive measures for managing widespread metabolic diseases, containing dietary recommendations, lifestyle interventions, and the potential involvement of flavonoids;offers a comprehensive guide on how to effectively utilize flavonoids for therapeutic purposes. Audience This book is intended for researchers, scientists, clinicians/physicians, and public health professionals who work in pharmacology settings. The book is a vital tool for clinicians, nutritionists, and other healthcare professionals who are concerned about cutting-edge methods for dietary guidelines to gain an understanding of flavonoids and long-term metabolic disorders.

Discover the revolutionary potential of stem cell therapy and gain a comprehensive understanding of its applications, challenges, and ethical considerations across various medical fields with Stem Cell Therapeutics, a must-read for anyone interested in the future of medicine. Stem Cell Therapeutics delves into the forefront of medical research, exploring the revolutionary potential of stem cell therapy in combating a wide array of diseases. This comprehensive volume provides a thorough examination of the subject matter, offering insights into the latest advancements, methodologies, and applications of stem cell therapeutics. The book adopts a multidisciplinary approach, drawing upon expertise from fields such as biology, medicine, biotechnology, and bioengineering. Readers can expect to encounter in-depth discussions on the use of stem cells in treating various medical conditions, including neurodegenerative disorders, cardiovascular diseases, autoimmune conditions, and cancer. Each chapter provides a comprehensive overview of the current state of research for each disease, highlighting the challenges, successes, and prospects of stem cell-based therapies. Additionally, the book explores ethical considerations, regulatory frameworks, and commercialization strategies surrounding the field, ensuring a well-rounded understanding of the subject matter for readers at all levels of expertise.

This book provides a comprehensive understanding of the transformative potential of stem cell therapies for improving skin health and treating debilitating dermatological disorders. Stem Cell Therapy in Dermatological Disorders delves into the emerging field of stem cell therapy as a revolutionary approach to treating various dermatological conditions. This book provides a comprehensive overview of the science behind stem cell technology, focusing on its applications in skin regeneration, wound healing, and the management of chronic skin diseases. It examines the cellular and molecular mechanisms that make stem cells uniquely suited for dermatological use, exploring their ability to promote tissue repair, modulate inflammation, and restore the skin’s structural integrity. This book aims to bridge the gap between experimental research and clinical application, presenting up-to-date findings on the different types of stem cells used in dermatology, including mesenchymal stem cells, induced pluripotent stem cells, and embryonic stem cells. It highlights the role of stem cells in addressing disorders such as atopic dermatitis, psoriasis, vitiligo, and chronic non-healing wounds. Readers will find in-depth discussions on current therapeutic techniques, the challenges of translating preclinical studies to human trials, and the ethical considerations associated with stem cell therapies. In addition to discussing the state-of-the-art in stem cell-based treatments, the book also casts an eye on the future, identifying gaps in existing knowledge and potential areas for innovation. The authors provide insights into novel delivery systems, genetic engineering advancements, and combinatory approaches that may enhance the efficacy and safety of stem cell therapies in dermatology. This volume serves as an essential resource for dermatologists, researchers, and clinicians seeking to understand the transformative potential of stem cell therapies in improving skin health and treating debilitating dermatological disorders. Readers will find the book: Explores the latest breakthroughs in stem cell therapy for skin disorders;Bridges the gap between basic science and clinical applications;Discusses mesenchymal stem cells (MSCs), iPSCs, and exosome-based therapies.Audience Dermatologists, dermatopathologists, plastic surgeons, medical aestheticians, researchers, clinicians, and biotechnology and pharmaceutical professionals involved in regenerative medicine and aesthetic dermatology.

This new book explores the latest advances in probiotic research in the prevention and treatment of cancer. The volume first provides an introduction to prebiotics, probiotics, and synbiotics, covering the anticancer properties of probiotic microorganisms, the impact of their metabolites, the potential mechanisms of probiotic chemoprevention, and the feasibility of incorporating probiotics into cancer care strategies. The volume looks at studies that examine the efficacy of probiotics in the treatment and management of such cancers as bladder cancer, colorectal cancer, cervical cancers, lung cancer, brain cancer, and others. It takes an in-depth look at gut microbiota and the role of probiotics as immune boosters and also considers possible toxicology challenges of probiotics as well.

This new volume delves into the extensive new research on inflammatory bowel disease (IBD) and gut microbiota that has led to effective therapeutic interventions. Highlighting novel methodologies and innovative treatment approaches, the book provides a comprehensive investigation of IBD, exploring the significance of gut microbiota and investigating the fundamental role of microbial imbalances in the initiation and progression of inflammatory processes as well as the prominent therapeutic consequences of restoring microbial homeostasis. From nanoparticle-based drug delivery systems that advance the bioavailability of the medicament to the use of bio-nanosensors for early detection of disease, the book covers a broad spectrum of inventions that hold potential for revolutionizing IBD treatment. The authors look at the impact of nutraceuticals, probiotics, prebiotics, functional foods, oral siRNA-based nanomedicine, and other novel drug delivery systems on gut microbiota for the management of IBD. The book also explores the role of reactive oxygen species (ROSs), superoxide dismutases (SODs), and inflammation in association with gut microbiota and IBD.

The emerging role of gut microbiota and postbiotics has implications for the management of not only human health and diseases, but also colorectal cancer in particular, as these elements influence colorectal cancer pathogenesis, treatment, and prevention.

This book offers a wide perspective on the fundamental and state-of-the-art knowledge in radiobiology, radiation oncology, and the connection between both fields. Chapters incorporate basic concepts of cancer biology and radiobiology with advances in radiotherapy in cancer treatment for various types of cancer. Chapters review one or more areas of radiation oncology with topics ranging from the application of radiotherapy in various cancers, the use of advanced techniques such as FLASH radiotherapy, applications of artificial intelligence in treatment planning, and more importantly, the current and potential strategies to reduce the toxic effects of radiation. This book incorporates interdisciplinary concepts by exploring recent approaches like radiogenomics for personalizing radiotherapy and the effects of the microbiome on radiation research.Teaching the basics of radiobiology and connections between the theory and the practical aspects of radiotherapy techniques, this book is a useful reference for cancer researchers, practitioners, interdisciplinary researchers in related fields, and students in radiation oncology and radiobiology. Through this integration of strong scientific foundations and clinical applicability, this book provides future research directions and rationales for readers looking to expand their knowledge about radiation with the most recent and essential data on the subject.

Reactive oxygen species (ROS)-mediated inflammation plays a critical role in the onset and progression of various metabolic disorders, including obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD). Dysregulated ROS production leads to oxidative stress, which triggers chronic low-grade inflammation, disrupting cellular homeostasis and metabolic functions. This pathological interplay exacerbates insulin resistance, lipid accumulation, and mitochondrial dysfunction, creating a vicious cycle of metabolic dysregulation. Understanding the molecular mechanisms behind ROS-mediated inflammation is crucial for developing targeted therapeutic interventions to break this cycle and mitigate disease progression.This comprehensive book bridges the gap between fundamental molecular insights and translational therapeutic strategies. It begins by delving into the signaling pathways involved, such as NF-κB and Nrf2, and highlighting the role of key players like mitochondria and antioxidant systems. Later chapters explore emerging therapeutic approaches, including postbiotics, natural antioxidants, and pharmacological agents, offering practical solutions for managing metabolic disorders. By addressing this critical intersection of inflammation, oxidative stress, and metabolism, this book is a valuable guide for researchers, clinicians, and healthcare professionals who aim to tackle the global burden of metabolic diseases effectively.

Cancer cells survive and thrive by radically reshaping the way they use energy, nutrients, and metabolic pathways. This book offers a clear and comprehensive exploration of this rapidly evolving field, revealing how tumors rewire core biochemical processes to sustain proliferation, evade cell death, and adapt to the pressures of the tumor microenvironment. From foundational concepts to cutting‑edge discoveries, the book provides an essential entry point for understanding the metabolic logic that underlies cancer progression. Central to this volume is an in‑depth examination of glutamine metabolism. Alongside this focus, the book extends broadly across the metabolic landscape, covering glycolysis, lipid synthesis and utilization, redox regulation, mitochondrial dynamics, and metabolic communication between cancer cells and their surrounding stromal and immune partners. Each chapter distills mechanistic insight while emphasizing translational relevance, bridging basic science with the latest therapeutic strategies and clinical applications. Written by leading researchers and clinicians, this book serves as a valuable resource for scientists, oncologists, and drug developers seeking to understand and target the metabolic vulnerabilities of cancer. Whether exploring metabolic reprogramming in cancer stem cells, evaluating biomarkers of metabolic states, or assessing emerging therapies and clinical trial data, readers will gain an integrated perspective on how metabolism shapes tumor behavior and influences treatment outcomes. This is an indispensable guide for anyone committed to advancing cancer research, improving patient care, and translating metabolic insights into meaningful therapeutic advances.

This book provides a comprehensive overview of the role of exosomes in brain diseases, including stroke, multiple sclerosis, Parkinson's disease, Alzheimer's disease, epilepsy, and depression. It covers the basics of exosome biogenesis, composition, and synthesis, as well as the therapeutic potential of exosomes in brain disorders. The correlation between exosomes and neuroinflammation, the challenges of using exosomes as a novel carrier, and engineered exosomes to deliver therapeutic protein are covered well in this book. Use of radiolabelled exosomes as a diagnostic tool and the toxicity studies of exosomes with potential overcome approaches. It is an essential resource for researchers, clinicians, and healthcare professionals working in the field of exosome research, especially on its applications in brain disorders.