Anoop Kumar - Böcker

Microbiota-Gut-Brain Axis and CNS Disorders: Recent Progress and Perspectives on Human Disease summarizes the main findings on gut-brain axis in different types of CNS disorders, providing a complete overview of the field. The content helps unravel the complex interactions of the microbiota-gut-brain-axis in CNS disorders to pave a better understanding of microbiota-mediated pathogenesis, avenues for noninvasive prognosis, and therapeutic possibilities leveraging microbiota-gut-brain-axis modulations. Coverage includes the role of the microbiota-gut-brain axis and gut virome on human diseases including Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, Depression and Anxiety, Autism Spectrum Disorder, Multiple Sclerosis, Stroke, and others.This book will satisfy the urgent need for a broader view of the current associations between gut microbiota alterations and development of CNS disorders, including the use of novel therapeutic approaches for restoring the correct intestinal bacteria content. It is the perfect reference for translational and clinical gut and microbiome researchers tackling the challenges of delivering genes and drugs in a more targeted and efficient manner for the treatment of CNS disorders.Discusses the development of both health and disease in interdisciplinary research involving gut microbiologyProvides an understanding the role of Microbiome-Gut-Brain axis in neurodegenerative and neurodevelopmental diseases, including central nervous system (CNS) malignanciesDelivers a compilation of current clinical studies to further investigate the role of diet in varying neurological disorders

Applications of Nanotherapeutics and Nanotheranostics in Managing Infectious Diseases discusses how nanotechnology aids in overcoming the existing traditional approaches in combating diseases. The book explores the emerging trends of using nanoparticles for nanotherapeutics and nanotheranostics and their role in the efficient diagnosis and treatment of infectious microbial diseases. Sections covers nanotherapeutic impregnated medical devices, nanotherapeutics as vaccines, related regulatory requirements, the application of nanotherapeutics and nanotheranostics in diagnosing and treating specific infectious diseases, including bacterial infections, viral infections, fungal infestations, parasitic infestations, and other infectious conditions.With chapter contributions from experts in the fields, this book offers a comprehensive reference for researchers, scientists, and industry professionals working on infectious diseases and the application of nanoparticles to effectively diagnose, treat, and manage them.Discusses the mechanisms behind the enhanced therapeutic potential of using nanomaterial as an efficient drug delivery system to meet the challenges of combating various complex diseasesEmphasizes the recent advances in interdisciplinary research on processing, morphology, structure, and properties of nanostructured materials and their applications in the treatment of infectious diseasesCovers different types of nanoparticles, their role in drug delivery and the latest updates in regulatory requirements, patents, clinical trials, and commercial flexibility

Cellular Therapies for Cancer Treatment: Advancements in Drug Delivery Strategies explores the innovative use of cellular therapy to combat cancer, placing an emphasis on state-of-the-art delivery approaches. By covering a variety of cellular therapies for cancer, such as stem cells, immune cells, and others, this book provides a comprehensive introduction to the field. It describes ways to deliver drugs that target cancer cells more efficiently, decrease off-target effects, and enhance therapy outcomes. Sections provide a brief overview of cancer cell biology, describe the need for advance drug delivery systems, and address challenges and future directions.The book also goes into the ideas behind cellular therapies and how they may overcome drug resistance and make existing cancer treatments more effective. By elaborating on the value of diversity and inclusion in cancer research and treatment, the book also emphasizes the importance of all patients having equal access to innovative therapies. All things considered, this book is a great tool for researchers, doctors, and students in the cancer treatment sector.Gives a comprehensive overview of cellular therapies for cancer treatment, covering basic principles and advanced applicationsProvides access to the latest research advancements, emerging trends, and innovative methodologies in clinical biochemistryOffers real-world case studies and practical insights, illustrating how clinical biochemistry principles are applied in healthcare and research

Inflammation and Cancer: Mechanisms, Diagnosis, and Therapeutic Strategies delves into the intricate relationship between inflammation and cancer, a crucial area of contemporary biomedical research. Sections provide an overview of inflammation's role in cancer, discussing molecular connections and signaling pathways. Chapters explore inflammatory pathways in various cancers, including breast, oral, lung, prostate, skin, and gastrointestinal cancers. The book also covers tumorigenesis, metastasis, preventive strategies, inflammatory biomarkers for cancer diagnosis, and innovative therapeutic designs. Final chapters focus on the dual role of platelets, targeting tumor-associated macrophages, novel treatment approaches, and recent advances in the field.This title offers substantial benefits to researchers, clinicians, and healthcare professionals by providing a thorough understanding of the cellular and molecular pathways linking inflammation and cancer, aiding in the development of effective anti-cancer immunotherapies. By highlighting the latest research and potential therapeutic strategies, this book serves as an essential resource for anyone dedicated to combating cancer through innovative and informed immunotherapeutic approaches.Explores the intricate relationship between inflammation and cancer, tumor initiation, and progressionProvides a comprehensive analyses of inflammatory pathways in various cancersOffers insights into molecular mechanisms and the inflammatory signaling pathways crucial for developing effective anti-cancer therapiesHighlights innovative immunotherapeutic strategies and preventive measures to more effectively target cancerConveys the latest research advancements and future directions in cancer-related inflammation studies

Mitochondria-targeted Drug Delivery Strategies for Cancer Therapy explores the innovative use of biocompatible, multifunctional nanoplatforms to target mitochondria for selective drug delivery, enhancing treatment efficacy while minimizing side effects. The book provides a comprehensive overview of the role of nanotechnology in cancer treatment, reviewing the basics of nanotechnology and cancer biology, advanced nanoengineering strategies, and the development of mitochondria-targeted drug delivery systems, such as liposomal therapies, photosensitizer nanoparticles, and peptides for cancer treatment, along with strategies to modulate mitochondrial functions using nanomaterials.This is a valuable resource to researchers and scientists interested in the application of nanotechnology for improved cancer therapy as it provides a thorough overview of real-world applications and future research trends as well as a discussion on overcoming challenges in mitochondrial targeting.Reviews the principles of mitochondria-targeted drug delivery, including the design of nanocarriers, mechanisms of mitochondrial targeting, and methods for evaluating delivery efficiencyIncludes case studies and examples from recent research to illustrate the application of nanotechnology in targeting mitochondria for cancer treatmentDiscusses future research directions in the field, including emerging trends and technologies that may further advance mitochondria-targeted drug delivery for cancer treatment

This book provides detailed concepts and information on principles and processes of signal analysis in pharmacovigilance along with case studies. It covers the fundamental concepts and principles of pharmacovigilance, emphasizing the need for robust signal detection and analysis methods. The book reviews the diverse array of databases and tools employed for signal detection, including electronic health records (EHRs), social media mining, claims data, and distributed data networks. In turn, the book discusses the application of molecular dynamics, molecular docking, and the use of the FDA Adverse Event Reporting System (FAERS) database in signal analysis. Toward the end, the book explores the identification, validation, and assessment of signals associated with vaccines. This book is useful for graduate, post-graduate students of pharmaceutical sciences, and scientists in pharmacology research and drug development.

Crops suffer from biotic and abiotic stress during their growing period. Biotic stress in crops is caused by living organisms, specifically viruses, bacteria, fungi, nematodes, insects, arachnids, phanerogamic plants, and weeds. They directly deprive their host of its nutrients leading to reduced plant vigor and, in extreme cases, death of the host plant causing up to 40% yield losses and significantly reducing the quality of the produce annually. This has led to increased concern over food safety and nutritional security in India as well as abroad. Climate change and human interventions have altered ecosystems, reducing biodiversity and creating new niches where pests and pathogens can thrive, and new pests and diseases of crops. The integrative strategies for the management of biotic stresses of crops include managing pests by enhancing the resistance of host plants. Biological, cultural, physical, and chemical methods are needed.In this book, 29 chapters are included covering the general topic and specific crop-based strategies to manage the stresses caused by insect pests and diseases of different crops such as cereals, pulses, oilseeds, vegetables, fruits, cash crops, medicinal and aromatic plants, spices, and plantation crops by using different approaches with the latest information. At the end of each chapter, references are cited which may facilitate the reader to get more detailed information. The book also focuses more on diagnosis of biotic stresses and management by adding recent information, which has practical utility.The purpose of this book is to provide recent information in the field of biotic stress management in crops to students, researchers, teachers, extension workers and farmers, and those who deal with crops that are vulnerable to biotic stress.

This book offers a comprehensive and multi-faceted examination of gastrointestinal inflammations, discussing factors that impact gut health. The initial chapters establish a foundational understanding of gastrointestinal inflammations and the critical role of the gut microbiota. The book then delves into the complex pathophysiology and various risk factors associated with these conditions, offering insights into the latest diagnostic, screening, and prevention techniques. It explores the dynamic interactions between the gut and the brain as well as the biochemical interplays involving short-chain fatty acids, reactive oxygen species, and superoxide dismutases. Additionally, the book thoroughly discusses the impact of genetics on gastrointestinal health, the interactions between antibiotics and gut microbiota, and the pivotal role of the immune system in inflammation. It highlights advancements in diagnostic technologies and gut microbiota-based strategies, along with the use of nanoparticles in treatment. The book also examines the psychological aspects associated with gastrointestinal inflammations, emphasizing the importance of mental health for physical well-being. It assesses the potential of functional foods, various types of nanocarriers, and plant-based bioactives in managing gastrointestinal inflammations. As such, this book is primarily intended for researchers and students in the fields of gastroenterology and microbiology.Key Features:Provides an extensive overview of gastrointestinal inflammations, starting from the basic concepts of the gut microbiota to complex pathophysiological aspectsDelves into the latest advancements in diagnostic, screening, and prevention techniques, highlighting cutting-edge technologies and approaches in gastroenterologyExplores the role of the immune system and the impact of genetics and diet on gastrointestinal healthExamines use of probiotics, prebiotics, postbiotics, and various nanotechnology-based approaches for gastrointestinal inflammation managementEmphasis on the psychological factors associated with gastrointestinal inflammations

This book comprehensively covers the principles, methodology, and applications of network pharmacology in drug discovery, pharmacovigilance, and precision medicine. The initial chapters guide readers through the principles and processes, detailing step-by-step procedures such as creating networks for compounds and disease targets. The intersection of network pharmacology with quantitative systems pharmacology is explored, along with an examination of various databases and essential software tools for conducting network pharmacological studies. It discusses the role of machine learning and AI in network pharmacology, delves into the application of systems biology for understanding complex diseases' pathogenesis, and highlights its contribution to drug discovery and repurposing. The book reviews the role of network pharmacology in different stages of drug discovery and repurposing, emphasizing its application in shaping drug formulations for enhanced efficacy and reduced side effects. Towards the end, it addresses translatability issues in drug discovery and repositioning predictions in clinical practice. This book caters to professionals, researchers, and advanced students in the pharmaceutical sciences. Key Features:Presents principles, methodologies, and applications of network pharmacologyExplores the intersection of network pharmacology with quantitative systems pharmacologyHighlights the role of machine learning and artificial intelligence in network pharmacologyReviews the role of network pharmacology in different stages of drug discovery and repurposingExamines the pivotal role of network pharmacology in precision medicine

This book comprehensively provides the research and validation of herbal medicines within modern clinical trials. The book covers the basics of herbal remedies, their historical and cultural contexts, and delves into specific methodologies such as traditional evidence-based medicine, reverse pharmacology, and integrative medicine. It examines pharmacokinetics and pharmacodynamics, herb-drug interactions, and outlines the roles of various stakeholders in herbal medicine trials. Detailed attention is given to quality control, standardization, and safety evaluation, alongside methods for conducting randomized clinical trials. Ethical and regulatory challenges are addressed extensively, with separate focus on regulations in the US, EU, and non-EU countries, including specific challenges in the Indian system of medicines. The text also highlights the use of artificial intelligence and machine learning in clinical trials, presents recent advancements, best practices, and the future trends in herbal medicine research.Key Features:· Provides a thorough overview of herbal medicines, detailing their historical and cultural backgrounds alongside modern scientific research· Explores specific research methodologies like traditional evidence-based medicine, reverse pharmacology, and integrative medicine approaches tailored to herbal medicines· Includes in-depth examinations of how herbal medicines interact within the body and with other drugs· Emphasizes the importance of standardization, quality control, and safety evaluation strategies in conducting clinical trials for herbal medicines· Discusses ethical and regulatory challenges, with specific sections on regulations in the U.S., EU, non-EU countriesThis book is an essential resource for regulatory professionals, researchers, and clinicians seeking to bridge traditional herbal practices with rigorous scientific research.

This book comprehensively reviews fundamental principles, ethical considerations, regulatory frameworks, and emerging trends in clinical research. The introductory chapters explore the fundamentals of clinical research, its historical context, and the pivotal role of key stakeholders. The book explores regulatory frameworks in various regions, including the USA, EU countries, non-EU countries, and India. It also delves into the implementation of International Conference on Harmonization (ICH) guidelines, ensuring compliance and quality in clinical trials. It meticulously dissects ethical considerations, delving into historical breaches to underscore the paramount importance of ethical integrity. The chapters outline regulatory standards, emphasize data accuracy and confidentiality, and prepare researchers for regulatory inspections and audits. Moreover, the chapter provides a concise yet comprehensive guide to protocol development and statistical analysis in clinical research. From the inception of research protocols to the intricacies of statistical analysis, the book offers practical insights and methodologies crucial for conducting rigorous and ethically sound research. Moreover, it critically examines emerging trends, from the integration of digital health technologies to the burgeoning role of machine learning and artificial intelligence. This book is intended for researchers, healthcare professionals, and regulatory stakeholders.Key Features: Provides an in-depth examination of the fundamental principles underlying clinical researchReview regulatory frameworks across multiple regions including the USA, EU, non-EU countries, and IndiaDiscusses the importance of ethics in clinical research, the role of ethical committees, and the informed consent processCovers fundamental clinical research methods, including study design, protocol development, and statistical analysisAddresses cutting-edge trends and innovations within clinical research, including the application of machine learning and AI tools

This detailed volume focuses on best practices and conditions for maintaining the most commonly used salamander species in the laboratory. Salamanders in Regeneration Research: Methods and Protocols guides readers through experimental manipulations in vivo and in vitro, respectively. With methods on targeting a wide variety of structures, ranging from the limb to the heart and to the brain, and methods for studying genetically modified organisms and tools for mining in the genomic databases. Written in the highly successful Methods in Molecular Biology series format, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and up-to-date, Salamanders in Regeneration Research: Methods and Protocols provides a comprehensive collection of methods chapters.

This detailed volume focuses on best practices and conditions for maintaining the most commonly used salamander species in the laboratory. Salamanders in Regeneration Research: Methods and Protocols guides readers through experimental manipulations in vivo and in vitro, respectively. With methods on targeting a wide variety of structures, ranging from the limb to the heart and to the brain, and methods for studying genetically modified organisms and tools for mining in the genomic databases. Written in the highly successful Methods in Molecular Biology series format, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and up-to-date, Salamanders in Regeneration Research: Methods and Protocols provides a comprehensive collection of methods chapters.

Peanut Agriculture and Production Technology: Integrated Nutrient Management focuses on agricultural techniques and integrated nutrient management of peanuts (Arachis hypogaea L.). Peanuts are the second most important oil crop of India, occupying 5.7 million hectares, with an average production of 0.8 ton/ha, which is 23.5% of the India’s total oil seed production. Worldwide annual production of shelled peanuts was 42 million metric tons in 2014. It is the world’s 4th most important source of edible oil and the 3rd most important source of vegetable protein. The volume includes basic and advanced information on production, agrotechniques, and integrated nutrient management of Arachis hypogaea L. crop plant. It studies the physiology of the peanut, looking at the proper environmental conditions for optimal growth as well as under various subnormal conditions. It explores the methods of nitrogen application as well as the influence of different sowing dates and population densities to harvest its full yield potential. The book covers methods to achieve balanced nutrition, including using organic manures in groundnut farming to enhance yielding ability.The book will be a rich resource for those in agriculture, horticulture, and allied sciences, particularly for agricultural scientists in plant and crop physiology, agronomy, and soil science. Farm owners and managers of peanut crops and production will also benefit from the information provided in this volume.

Peanut Agriculture and Production Technology: Integrated Nutrient Management focuses on agricultural techniques and integrated nutrient management of peanuts (Arachis hypogaea L.). Peanuts are the second most important oil crop of India, occupying 5.7 million hectares, with an average production of 0.8 ton/ha, which is 23.5% of the India’s total oil seed production. Worldwide annual production of shelled peanuts was 42 million metric tons in 2014. It is the world’s 4th most important source of edible oil and the 3rd most important source of vegetable protein. The volume includes basic and advanced information on production, agrotechniques, and integrated nutrient management of Arachis hypogaea L. crop plant. It studies the physiology of the peanut, looking at the proper environmental conditions for optimal growth as well as under various subnormal conditions. It explores the methods of nitrogen application as well as the influence of different sowing dates and population densities to harvest its full yield potential. The book covers methods to achieve balanced nutrition, including using organic manures in groundnut farming to enhance yielding ability.The book will be a rich resource for those in agriculture, horticulture, and allied sciences, particularly for agricultural scientists in plant and crop physiology, agronomy, and soil science. Farm owners and managers of peanut crops and production will also benefit from the information provided in this volume.

Using the philosophy of non-duality as a framework, Anoop Kumar takes you on an exploration of identity, the core factor that is at the heart of not only spirituality, but also science, philosophy, religion, and every other facet of life, including washing the dishes on Saturday night after the guests leave. But identity isn't only about us. It also influences what we see of the world around us. What is this world, after all? How does it relate to who we are and how we experience the world? As we explore these questions, the falseness of the dichotomy of you and the world around you is exposed. We are now upon a time in which our perspectives on spirituality, science, philosophy, and religion have evolved enough to stand together in the glare of the spotlight as we ask the most practical of questions: What is the common truth among all these? How does it change my life right now? How does it change the world? Is This a Dream? includes a Foreword by Deepak Chopra

This book provides conceptual information on the various processes involved in meta-analysis.

This book provides conceptual information on the various processes involved in meta-analysis.

The book explores the field of pharmacovigilance, its historical context, along with its critical role in ensuring the safety of medications across the world.

The book explores the field of pharmacovigilance, its historical context, along with its critical role in ensuring the safety of medications across the world.