Dr. Gautam Sethi is a tenured Associate Professor in the Department of Pharmacology at the Yong Loo Lin School of Medicine, National University of Singapore. His research focuses on elucidating the molecular mechanisms underlying cancer initiation and progression, particularly the activation of oncogenic transcription factors by carcinogens and inflammatory agents, and the identification of novel therapeutic inhibitors. Dr. Sethi has made substantial and direct scholarly contributions to the fields of gut microbiota, cancer pathophysiology, and host–microbiome interactions, with particular emphasis on immunotherapy, tumor microenvironment modulation, metabolic signaling, and therapy response prediction. He has authored numerous peer‑reviewed research and review articles in high‑impact journals, received multiple international awards, and serves on the editorial boards of more than 15 international journals. Dr. Fabio Fusi is an Associate Professor of Pharmacology at the Department of Biotechnology, Chemistry and Pharmacy at the University of Siena, Italy. With over 30 years of research experience, he has authored and co-authored more than 100 peer-reviewed publications, with significant contributions to the understanding of quercetin’s mechanisms in vascular smooth muscle. His collaborative research has also uncovered quercetin's role in modulating vascular reactivity through PKG-mediated KCa1.1 channel stimulation and its impact on perivascular adipose tissue signaling. As a principal investigator, he has led international projects on medicinal plants and natural product pharmacology with institutions in South Africa, Vietnam, and Slovakia. Dr. Fusi serves as Associate Editor for Frontiers in Pharmacology and is a member of the PhD program in Biochemistry and Molecular Biology at the University of Siena. His ongoing research continues to bridge molecular pharmacology and nutraceutical innovation, positioning him as a leading expert in the therapeutic potential of quercetin and related compounds Dr Lekshmi R. Nath is working as an Associate Professor in the Department of Pharmacognosy at Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, India. She pursued her PhD. in Cancer Research Program. She has more than 50 publications and has been invited as a resource person to many national and international conferences. She is the editorial board member and reviewer of high-impact scientific journals. Her current research interest includes the study of signalling events associated with the fatty liver to Hepatocellular carcinoma, elucidating the role of plant-derived pure compounds in cancer chemoprevention, chemo sensitization, and chemotherapy. She is also exploring the potential of traditional knowledge for cancer and various infectious diseases, their mechanism of action and validation through pre-clinical models

• Part I – Introduction to Quercetin Research1. An overview of Quercetin in Drug Discovery2. Pharmacological Properties3. Quercetin and ion channels: the good, the bad and the not so uglyPart II - Therapeutic Applications: focus on cardiovascular diseases4. Integrative AI and Bioinformatic Strategies to Elucidate Quercetin’s Cardiovascular Pharmacological Profile5. How to improve quercetin cardiovascular and antidiabetic activity through structural modification6. The effect of quercetin on lipid metabolismPart III - Therapeutic Applications: Focus on Cardiovascular diseases7. Antioxidant, anti-inflammatory, and anticancer activities8. Multitarget inhibitory properties - Signaling pathways and molecular targets9. Anti-proliferative, anti-metastatic and anti- angiogenic effects of quercetin10. Mechanisms of chemopreventative action of quercetinPart IV - Other Therapeutic Applications11. Dermatology, gastroenterology and ophthalmology12. Role of quercetin in treatment of inflammatory diseases13. Quercetin in Obesity Management: Biological Actions, Preclinical Insights, and Translational Challenges14. Alzheimer’s DiseasePart V - Drug Development15. Augmented quercetin: synthetic derivatives and prodrugs16. Bioavailability17. Drug formulation and deliveryPart VI - Clinical Application18. Quercetin in Human Health

Dr. Gautam Sethi is a tenured Associate Professor in the Department of Pharmacology at the Yong Loo Lin School of Medicine, National University of Singapore. His research focuses on elucidating the molecular mechanisms underlying cancer initiation and progression, particularly the activation of oncogenic transcription factors by carcinogens and inflammatory agents, and the identification of novel therapeutic inhibitors. Dr. Sethi has made substantial and direct scholarly contributions to the fields of gut microbiota, cancer pathophysiology, and host–microbiome interactions, with particular emphasis on immunotherapy, tumor microenvironment modulation, metabolic signaling, and therapy response prediction. He has authored numerous peer‑reviewed research and review articles in high‑impact journals, received multiple international awards, and serves on the editorial boards of more than 15 international journals. Dr. Fabio Fusi is an Associate Professor of Pharmacology at the Department of Biotechnology, Chemistry and Pharmacy at the University of Siena, Italy. With over 30 years of research experience, he has authored and co-authored more than 100 peer-reviewed publications, with significant contributions to the understanding of quercetin’s mechanisms in vascular smooth muscle. His collaborative research has also uncovered quercetin's role in modulating vascular reactivity through PKG-mediated KCa1.1 channel stimulation and its impact on perivascular adipose tissue signaling. As a principal investigator, he has led international projects on medicinal plants and natural product pharmacology with institutions in South Africa, Vietnam, and Slovakia. Dr. Fusi serves as Associate Editor for Frontiers in Pharmacology and is a member of the PhD program in Biochemistry and Molecular Biology at the University of Siena. His ongoing research continues to bridge molecular pharmacology and nutraceutical innovation, positioning him as a leading expert in the therapeutic potential of quercetin and related compounds Dr Lekshmi R. Nath is working as an Associate Professor in the Department of Pharmacognosy at Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, India. She pursued her PhD. in Cancer Research Program. She has more than 50 publications and has been invited as a resource person to many national and international conferences. She is the editorial board member and reviewer of high-impact scientific journals. Her current research interest includes the study of signalling events associated with the fatty liver to Hepatocellular carcinoma, elucidating the role of plant-derived pure compounds in cancer chemoprevention, chemo sensitization, and chemotherapy. She is also exploring the potential of traditional knowledge for cancer and various infectious diseases, their mechanism of action and validation through pre-clinical models

• Part I – Introduction to Quercetin Research1. An overview of Quercetin in Drug Discovery2. Pharmacological Properties3. Quercetin and ion channels: the good, the bad and the not so uglyPart II - Therapeutic Applications: focus on cardiovascular diseases4. Integrative AI and Bioinformatic Strategies to Elucidate Quercetin’s Cardiovascular Pharmacological Profile5. How to improve quercetin cardiovascular and antidiabetic activity through structural modification6. The effect of quercetin on lipid metabolismPart III - Therapeutic Applications: Focus on Cardiovascular diseases7. Antioxidant, anti-inflammatory, and anticancer activities8. Multitarget inhibitory properties - Signaling pathways and molecular targets9. Anti-proliferative, anti-metastatic and anti- angiogenic effects of quercetin10. Mechanisms of chemopreventative action of quercetinPart IV - Other Therapeutic Applications11. Dermatology, gastroenterology and ophthalmology12. Role of quercetin in treatment of inflammatory diseases13. Quercetin in Obesity Management: Biological Actions, Preclinical Insights, and Translational Challenges14. Alzheimer’s DiseasePart V - Drug Development15. Augmented quercetin: synthetic derivatives and prodrugs16. Bioavailability17. Drug formulation and deliveryPart VI - Clinical Application18. Quercetin in Human Health

Dr. Gautam Sethi is a tenured Associate Professor in the Department of Pharmacology at the Yong Loo Lin School of Medicine, National University of Singapore. His research focuses on elucidating the molecular mechanisms underlying cancer initiation and progression, particularly the activation of oncogenic transcription factors by carcinogens and inflammatory agents, and the identification of novel therapeutic inhibitors. Dr. Sethi has made substantial and direct scholarly contributions to the fields of gut microbiota, cancer pathophysiology, and host–microbiome interactions, with particular emphasis on immunotherapy, tumor microenvironment modulation, metabolic signaling, and therapy response prediction. He has authored numerous peer‑reviewed research and review articles in high‑impact journals, received multiple international awards, and serves on the editorial boards of more than 15 international journals. Dr. Fabio Fusi is an Associate Professor of Pharmacology at the Department of Biotechnology, Chemistry and Pharmacy at the University of Siena, Italy. With over 30 years of research experience, he has authored and co-authored more than 100 peer-reviewed publications, with significant contributions to the understanding of quercetin’s mechanisms in vascular smooth muscle. His collaborative research has also uncovered quercetin's role in modulating vascular reactivity through PKG-mediated KCa1.1 channel stimulation and its impact on perivascular adipose tissue signaling. As a principal investigator, he has led international projects on medicinal plants and natural product pharmacology with institutions in South Africa, Vietnam, and Slovakia. Dr. Fusi serves as Associate Editor for Frontiers in Pharmacology and is a member of the PhD program in Biochemistry and Molecular Biology at the University of Siena. His ongoing research continues to bridge molecular pharmacology and nutraceutical innovation, positioning him as a leading expert in the therapeutic potential of quercetin and related compounds Dr Lekshmi R. Nath is working as an Associate Professor in the Department of Pharmacognosy at Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, India. She pursued her PhD. in Cancer Research Program. She has more than 50 publications and has been invited as a resource person to many national and international conferences. She is the editorial board member and reviewer of high-impact scientific journals. Her current research interest includes the study of signalling events associated with the fatty liver to Hepatocellular carcinoma, elucidating the role of plant-derived pure compounds in cancer chemoprevention, chemo sensitization, and chemotherapy. She is also exploring the potential of traditional knowledge for cancer and various infectious diseases, their mechanism of action and validation through pre-clinical models

• Part I – Introduction to Quercetin Research1. An overview of Quercetin in Drug Discovery2. Pharmacological Properties3. Quercetin and ion channels: the good, the bad and the not so uglyPart II - Therapeutic Applications: focus on cardiovascular diseases4. Integrative AI and Bioinformatic Strategies to Elucidate Quercetin’s Cardiovascular Pharmacological Profile5. How to improve quercetin cardiovascular and antidiabetic activity through structural modification6. The effect of quercetin on lipid metabolismPart III - Therapeutic Applications: Focus on Cardiovascular diseases7. Antioxidant, anti-inflammatory, and anticancer activities8. Multitarget inhibitory properties - Signaling pathways and molecular targets9. Anti-proliferative, anti-metastatic and anti- angiogenic effects of quercetin10. Mechanisms of chemopreventative action of quercetinPart IV - Other Therapeutic Applications11. Dermatology, gastroenterology and ophthalmology12. Role of quercetin in treatment of inflammatory diseases13. Quercetin in Obesity Management: Biological Actions, Preclinical Insights, and Translational Challenges14. Alzheimer’s DiseasePart V - Drug Development15. Augmented quercetin: synthetic derivatives and prodrugs16. Bioavailability17. Drug formulation and deliveryPart VI - Clinical Application18. Quercetin in Human Health