The Origins of Genome Architecture

Michael Lynch is Distinguished Professor of Biology at Indiana University. He received his B.S. in Biology from St. Bonaventure University, and his Ph.D. in Ecology from the University of Minnesota. Dr. Lynch has served as President of both the Society for the Study of Evolution and the American Genetic Association, and is a past council member of the Society for Molecular Biology and Evolution, and a fellow of the American Academy of Arts and Sciences. His research is focused on mechanisms of evolution at the gene, genomic, cellular, and phenotypic levels, with special attention being given to the roles of mutation, random genetic drift, and recombination.

This book is a must-read for every genome researcher. It is the most up-to-date and thorough summary of genome evolution published. Almost every page introduces interesting, unanswered problems, making it a gold mine for graduate students in search of a thesis topic."

• The Origin of Eukaryotes.- Genome Size and Organismal Complexity.- The Human Genome.- Why Population Size Matters.- Three Keys to Chromosomal Integrity.- The Nucleotide-composition Landscape.- Mobile Genetic Elements.- Genomic Expansion by Gene Duplication.- Genes in Pieces.- Transcription and Regulatory-region Complexity.- Expansion and Contraction of Organelle Genomes.- Sex Chromosome Evolution.- Genomfart.