Joseph T. Coyle - Böcker

Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions.

This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases.

Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material

Harris' Developmental Neuropsychiatry: The Interface with Cognitive and Social Neuroscience provides updated information to the first edition which was awarded Dewey's Medical Book of the Year. The outcome of many discussions with faculty members, residents, medical students, and nonmedical professionals over the past three decades at the Johns Hopkins Medical Institution, Harvard Medical School, and McLean Hospital, this revamped second edition provides a comprehensive summary of knowledge and literature acquired through the authors' work with children and adolescents with developmental disorders and their families. This second edition features new material including epigenetics, social and affective neuroscience, updated DSM definitions and criteria for specific disorders, as well as all the latest genetics from the past 15 years. Harris' Developmental Neurospychiatry will be an invaluable resource for medical and graduate students.

N-acetylaspartate, or NAA, is the acetylated form of the amino acid aspartate, and it is present exclusively in the nervous system. Indeed, NAA is one of the most highly concentrated chemicals found in the brain of humans and animals, and yet the functions served by this brain-specific metabolite remain elusive, and controversial. Despite the uncertainties surrounding the functions of NAA in the development and operation of the nervous system, this molecule has attracted the attention of researchers and clinicians for two distinct reasons. First, the acetyl proton on NAA gives off a very prominent signal in water-suppressed, proton magnetic resonance spectroscopy (MRS), which permits clinicians to monitor levels of NAA in the brains of patients in a non-invasive manner. Because NAA is found primarily in neurons, and because the levels in the brain have been found to change rapidly after injury, or slowly during neurodegenerative diseases, MRS has become a preferred method of analyzing nerve cell dysfunction and death without surgical intervention. The second reason that NAA has attracted attention in recent years is that a congenital genetic disorder of NAA metabolism has been found to be the cause of the neurodegenerative disorder known as Canavan’s disease. Canavan’s disease is an inherited leukodystrophy that involves myelination pathologies of cortical white matter, leading to death within 10 years of birth. The genetic mutation results in a defective enzyme that de-acetylates NAA in the brain, resulting in a significant rise in NAA levels in the brain and urine. This enzyme, known as aspartoacylase (ASPA), appears to be involved in the process of myelination, such that a defective enzyme results in a disruption of the myelination of nerve fibers during development. The purpose of this symposium is to bring together investigators from around the world who are interested in the study of NAA, and the roles it plays in neuronaldevelopment and functioning. It is hoped that bringing researchers and clinicians together in such a forum will facilitate rapid progress in this emerging field, and will help lead to discoveries that can alleviate the suffering caused by a deadly, inheritable infantile disease.

Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.

Hypnosis, confabulation, source amnesia, flashbulb memories, repression--these and numerous additional topics are explored in this timely collection of essays by eminent scholars in a range of disciplines. This is the first book on memory distortion to unite contributions from cognitive psychology, psychopathology, psychiatry, neurobiology, sociology, history, and religious studies. It brings the most relevant group of perspectives to bear on some key contemporary issues, including the value of eyewitness testimony and the accuracy of recovered memories of sexual abuse.The distinguished contributors to this volume explore the full range of biological phenomena and social ideas relevant to understanding memory distortion, including the reliability of children's recollections, the effects of hypnosis on memory, and confabulation in brain-injured patients. They also look into the activity and role of brain systems, cellular bases of memory distortion, and the effects of emotion and trauma on the accuracy of memory. In a section devoted to the social aspects of memory distortion, additional essays analyze the media's part in distorting social memory, factors influencing historical reconstruction of the collective past, and memory distortion in religion and other cultural constructs. Daniel Schacter launches the collection with a history of psychological memory distortions. Subsequent highlights include new empirical findings on memory retrieval by a pioneer in the field, some of the foremost research on computational models, studies of the relationship between emotion and memory, new findings on amnesia by a premier neuroscientist, and reflections on the power of collective amnesia in U.S. history, the Nazi Holocaust, and ancient Egypt.