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2 produkter
2 produkter
Origins of Depression: Current Concepts and Approaches
Report of the Dahlem Workshop on The Origins of Depression: Current Concepts and Approaches Berlin 1982, Oct.31 – Nov. 5
Häftad, Engelska, 2011
1 105 kr
Skickas inom 10-15 vardagar
3 and a fraction mayor may not respond to treatment. On the behavioral level, animal research shows that a variety of experimental conditions can induce de pression. The same is true in the field of treatment, where pharmacologically highly different drugs can equally alleviate depression in animals and hu mans. The question as to whether this is due to a heterogeneity of depressive subjects based on different pathogenetic mechanisms is open to discussion. We can look for common features of all possible causal factors in the hope of finding a single basic mechanism. Many divergent findings may also be ex plained as peripheral changes of a highly complicated dynamic system. In the field of psychopharmacology, a circular reasoning has become evident in the sense that originally the clinical antidepressive response was founded on empirical grounds only. In a second step, an attempt was made to characterize some clinically active compounds pharmacologically, and in a third, further compounds were developed based on aspects of the pharmaco logical profiles. Moreover, the post hoc development of a pharmacological screening method has the serious disadvantage of delaying breakthroughs into new fields.
Del 16 - Journal of Neural Transmission. Supplementa
Current Topics in Extrapyramidal Disorders
Häftad, Engelska, 2011
556 kr
Skickas inom 10-15 vardagar
The scientific work of Walther Birkmayer is grounded on his ability to turn what was often a mass of clinical details into the basis for a hypothesis for a new therapeutic approach toward solving the problems of a patient's illness. Birkmayer first became known when, during the Second World War, he built up a clinic for brain injuries in Vienna, in which over 3000 patients were treated. The study of changes in the autonomic functions of the nervous system in these patients as well as the problems of rehabilitation were published in a monograph, "Hirn- verletzungen". Consequently, this was his major scientific interest during the post-war years. His book, "Klinik und Therapie der vegetativen Funktionsstorungen" published with W. Winkler, brought Birkmayer recognition in the German-speaking world. In 1954 he took over the Neurological Department of the Geriatric Hospital of Vienna in Lainz, where he remained until his retirement in 1975. International acclaim followed his breakthrough with the clinical application of L-DOPA in Parkinson's disease.Birkmayer, as a strong adherent to the scientific interpretation of neurological and psychiatric disease, has encouraged multidisciplinary research. This is reflected in his establishment of the former Ludwig Boltzmann- Institute of Neurochemistry, in which pharmacological, biochemical and histopathological research into neuropsychiatric diseases was performed under one roof. Further to his initial work on L-DOPA, Birkmayer has been in the forefront of supplementary parkinsonian therapy using enzyme inhibitors: benserazide in 1967, unselective monoamine oxidase inhibitors in 1962 and deprenyl in 1975.