Emmanuel Lesaffre - Böcker
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9 produkter
9 produkter
Survival Analysis with Interval-Censored Data
A Practical Approach with Examples in R, SAS, and BUGS
Häftad, Engelska, 2020
738 kr
Skickas inom 10-15 vardagar
Survival Analysis with Interval-Censored Data: A Practical Approach with Examples in R, SAS, and BUGS provides the reader with a practical introduction into the analysis of interval-censored survival times. Although many theoretical developments have appeared in the last fifty years, interval censoring is often ignored in practice. Many are unaware of the impact of inappropriately dealing with interval censoring. In addition, the necessary software is at times difficult to trace. This book fills in the gap between theory and practice. Features:-Provides an overview of frequentist as well as Bayesian methods.-Include a focus on practical aspects and applications.-Extensively illustrates the methods with examples using R, SAS, and BUGS. Full programs are available on a supplementary website.The authors:Kris Bogaerts is project manager at I-BioStat, KU Leuven. He received his PhD in science (statistics) at KU Leuven on the analysis of interval-censored data. He has gained expertise in a great variety of statistical topics with a focus on the design and analysis of clinical trials.Arnošt Komárek is associate professor of statistics at Charles University, Prague. His subject area of expertise covers mainly survival analysis with the emphasis on interval-censored data and classification based on longitudinal data. He is past chair of the Statistical Modelling Society and editor of Statistical Modelling: An International Journal.Emmanuel Lesaffre is professor of biostatistics at I-BioStat, KU Leuven. His research interests include Bayesian methods, longitudinal data analysis, statistical modelling, analysis of dental data, interval-censored data, misclassification issues, and clinical trials. He is the founding chair of the Statistical Modelling Society, past-president of the International Society for Clinical Biostatistics, and fellow of ISI and ASA.
761 kr
Skickas inom 7-10 vardagar
The growth of biostatistics has been phenomenal in recent years and has been marked by considerable technical innovation in both methodology and computational practicality. One area that has experienced significant growth is Bayesian methods. The growing use of Bayesian methodology has taken place partly due to an increasing number of practitioners valuing the Bayesian paradigm as matching that of scientific discovery. In addition, computational advances have allowed for more complex models to be fitted routinely to realistic data sets. Through examples, exercises and a combination of introductory and more advanced chapters, this book provides an invaluable understanding of the complex world of biomedical statistics illustrated via a diverse range of applications taken from epidemiology, exploratory clinical studies, health promotion studies, image analysis and clinical trials.Key Features: Provides an authoritative account of Bayesian methodology, from its most basic elements to its practical implementation, with an emphasis on healthcare techniques.Contains introductory explanations of Bayesian principles common to all areas of application.Presents clear and concise examples in biostatistics applications such as clinical trials, longitudinal studies, bioassay, survival, image analysis and bioinformatics.Illustrated throughout with examples using software including WinBUGS, OpenBUGS, SAS and various dedicated R programs.Highlights the differences between the Bayesian and classical approaches.Supported by an accompanying website hosting free software and case study guides.Bayesian Biostatistics introduces the reader smoothly into the Bayesian statistical methods with chapters that gradually increase in level of complexity. Master students in biostatistics, applied statisticians and all researchers with a good background in classical statistics who have interest in Bayesian methods will find this book useful.
1 220 kr
Skickas inom 7-10 vardagar
Statistical and Methodological Aspects of Oral Health Research provides oral health researchers with an overview of the methodological aspects that are important in planning, conducting and analyzing their research projects whilst also providing biostatisticians with an idea of the statistical problems that arise when tackling oral health research questions. This collection presents critical reflections on oral health research and offers advice on practical aspects of setting up research whilst introducing the reader to basic as well as advanced statistical methodology.Features: An introduction to research methodology and an exposition of the state of the art.A variety of examples from oral health research.Contributions from well-known oral health researchers, epidemiologists and biostatisticians, all of whom have rich experience in this area.Recent developments in statistical methodology prompted by a variety of dental applications.Presenting both an introduction to research methodology and an exposition of the latest advances in oral health research, this book will appeal both beginning and experienced oral health researchers as well as biostatisticians and epidemiologists.
4 497 kr
Skickas inom 7-10 vardagar
Offers an in-depth report on advanced statistical tools for public health disease surveillance, which is the result of a prestigious World Health Organisation (WHO) and EU Biomed programme initiative. Traditionally, the role of public health disease surveillance has been to identify and evaluate morbidity and mortality but increasingly, more sophisticated methods are being applied as the authorities extend their studies to include control and prevention of disease. This book brings together leading experts to discuss complex methodologies for the statistical evaluation of disease mapping and risk assessment. It includes a broad variety of statistical techniques and where appropriate, examples are included on topical issues such as the analysis of putative health hazards. For easy reference the text is presented in five distinct sections, each with an introductory review: * Disease Mapping * Clustering of Disesase * Ecological Analysis * Risk Assessment for Putative Sources of Hazard * Public Health Applications and Case Studies Representative of the most pertinent issues within disease surveillance and mapping, this book will provide an accessible overview for statisticians and epidemiologists.
724 kr
Skickas inom 10-15 vardagar
Since the early 2000s, there has been increasing interest within the pharmaceutical industry in the application of Bayesian methods at various stages of the research, development, manufacturing, and health economic evaluation of new health care interventions. In 2010, the first Applied Bayesian Biostatistics conference was held, with the primary objective to stimulate the practical implementation of Bayesian statistics, and to promote the added-value for accelerating the discovery and the delivery of new cures to patients.This book is a synthesis of the conferences and debates, providing an overview of Bayesian methods applied to nearly all stages of research and development, from early discovery to portfolio management. It highlights the value associated with sharing a vision with the regulatory authorities, academia, and pharmaceutical industry, with a view to setting up a common strategy for the appropriate use of Bayesian statistics for the benefit of patients. The book covers:Theory, methods, applications, and computingBayesian biostatistics for clinical innovative designsAdding value with Real World EvidenceOpportunities for rare, orphan diseases, and pediatric developmentApplied Bayesian biostatistics in manufacturingDecision making and Portfolio management Regulatory perspective and public health policies Statisticians and data scientists involved in the research, development, and approval of new cures will be inspired by the possible applications of Bayesian methods covered in the book. The methods, applications, and computational guidance will enable the reader to apply Bayesian methods in their own pharmaceutical research.
2 166 kr
Skickas inom 10-15 vardagar
Since the early 2000s, there has been increasing interest within the pharmaceutical industry in the application of Bayesian methods at various stages of the research, development, manufacturing, and health economic evaluation of new health care interventions. In 2010, the first Applied Bayesian Biostatistics conference was held, with the primary objective to stimulate the practical implementation of Bayesian statistics, and to promote the added-value for accelerating the discovery and the delivery of new cures to patients.This book is a synthesis of the conferences and debates, providing an overview of Bayesian methods applied to nearly all stages of research and development, from early discovery to portfolio management. It highlights the value associated with sharing a vision with the regulatory authorities, academia, and pharmaceutical industry, with a view to setting up a common strategy for the appropriate use of Bayesian statistics for the benefit of patients. The book covers: Theory, methods, applications, and computing Bayesian biostatistics for clinical innovative designs Adding value with Real World Evidence Opportunities for rare, orphan diseases, and pediatric development Applied Bayesian biostatistics in manufacturing Decision making and Portfolio management Regulatory perspective and public health policies Statisticians and data scientists involved in the research, development, and approval of new cures will be inspired by the possible applications of Bayesian methods covered in the book. The methods, applications, and computational guidance will enable the reader to apply Bayesian methods in their own pharmaceutical research.
Survival Analysis with Interval-Censored Data
A Practical Approach with Examples in R, SAS, and BUGS
Inbunden, Engelska, 2017
1 033 kr
Skickas inom 10-15 vardagar
Survival Analysis with Interval-Censored Data: A Practical Approach with Examples in R, SAS, and BUGS provides the reader with a practical introduction into the analysis of interval-censored survival times. Although many theoretical developments have appeared in the last fifty years, interval censoring is often ignored in practice. Many are unaware of the impact of inappropriately dealing with interval censoring. In addition, the necessary software is at times difficult to trace. This book fills in the gap between theory and practice. Features:-Provides an overview of frequentist as well as Bayesian methods.-Include a focus on practical aspects and applications.-Extensively illustrates the methods with examples using R, SAS, and BUGS. Full programs are available on a supplementary website.The authors:Kris Bogaerts is project manager at I-BioStat, KU Leuven. He received his PhD in science (statistics) at KU Leuven on the analysis of interval-censored data. He has gained expertise in a great variety of statistical topics with a focus on the design and analysis of clinical trials.Arnošt Komárek is associate professor of statistics at Charles University, Prague. His subject area of expertise covers mainly survival analysis with the emphasis on interval-censored data and classification based on longitudinal data. He is past chair of the Statistical Modelling Society and editor of Statistical Modelling: An International Journal.Emmanuel Lesaffre is professor of biostatistics at I-BioStat, KU Leuven. His research interests include Bayesian methods, longitudinal data analysis, statistical modelling, analysis of dental data, interval-censored data, misclassification issues, and clinical trials. He is the founding chair of the Statistical Modelling Society, past-president of the International Society for Clinical Biostatistics, and fellow of ISI and ASA.
Understanding Evidence-Based Rheumatology
A Guide to Interpreting Criteria, Drugs, Trials, Registries, and Ethics
Inbunden, Engelska, 2014
1 105 kr
Skickas inom 10-15 vardagar
It is imperative that health professionals caring for patients with rheumatic diseases understand how to correctly interpret evidence in their field, taking into account the merits and shortcomings of available data. Understanding Evidence-Based Rheumatology offers a practical assessment of criteria, drugs, trials, and registries and provides useful tools for successfully interpreting this data. The book introduces readers to basic analysis of trial design, statistics and application of data through no-nonsense, easy-to-follow insights. Using numerous examples, chapters outline the difficulties physicians encounter when measuring disease activity in rheumatology and offer strategies for systematically approaching these situations. Ethical issues in study design and reporting are examined and the book closes with a summary of future directions for scientific and clinical studies in rheumatology.Understanding Evidence-Based Rheumatology is an invaluable resource for trainees, clinicians and scientists, preparing them with the necessary tools to correctly gather evidence and shed light on the difficult practice of rheumatology.
Understanding Evidence-Based Rheumatology
A Guide to Interpreting Criteria, Drugs, Trials, Registries, and Ethics
Häftad, Engelska, 2016
1 738 kr
Skickas inom 5-8 vardagar
It is imperative that health professionals caring for patients with rheumatic diseases understand how to correctly interpret evidence in their field, taking into account the merits and shortcomings of available data. Understanding Evidence-Based Rheumatology offers a practical assessment of criteria, drugs, trials, and registries and provides useful tools for successfully interpreting this data. The book introduces readers to basic analysis of trial design, statistics and application of data through no-nonsense, easy-to-follow insights. Using numerous examples, chapters outline the difficulties physicians encounter when measuring disease activity in rheumatology and offer strategies for systematically approaching these situations. Ethical issues in study design and reporting are examined and the book closes with a summary of future directions for scientific and clinical studies in rheumatology.Understanding Evidence-Based Rheumatology is an invaluable resource for trainees, clinicians and scientists, preparing them with the necessary tools to correctly gather evidence and shed light on the difficult practice of rheumatology.