Frederik Barkhof – Författare

Functional magnetic resonance imaging (FMRI) has become the most widely used method for imaging normal brain function in a relatively short period of time. The use of FMRI in clinically related research has been much slower; however, FMRI is now becoming a valuable tool in the study of many neurological and psychiatric disorders.This book explains the status of current clinical applications of FMRI in preoperative evaluation, diagnosis and discrimination of pathology, and in understanding recovery, therapeutics and rehabilitation of neurological and psychiatric conditions. Individual chapters cover the use of FMRI in the preoperative assessment of both motor function and language as well as in the assessment of age-related changes in memory. More focused chapters cover the use of FMRI in specific medical conditions including dementia, schizophrenia, depression and anxiety disorders, stroke, Parkinson's disease and multiple sclerosis. The book concludes with a chapter on the role of FMRI in monitoring changes in brain function following exposure to clinical pharmacotherapeutics and experimental drug compounds. This book will be of interest to both novice FMRI researchers and expert FMRI scientists as well as to clinicans in neurology, radiology and psychiatry.

In this issue of Neuroimaging Clinics, guest editors Drs. Frederik Barkhof and Yaou Liu bring their considerable expertise to the topic of Multiple Sclerosis and Associated Demyelinating Disorders. Top experts in the field discuss advanced brain imaging in CNS demyelinating diseases; new imaging markers in MS and related disorders: smoldering inflammation and central vein sign; the use of AI in MS and white matter disease; optic nerve imaging in MS and related disorders; atypical demyelinating disorders; and more. Co-Editor Frederik Barkhof, MD, has received the National Multiple Sclerosis Society and the American Academy of Neurology’s 2018 John Dystel Prize for Multiple Sclerosis Research for his many years of outstanding research in the field of MS, especially in advancing the understanding and clinical use of brain imaging.

The role of imaging of the brain and spinal cord is described across the full range of relevant conditions, including, cerebrovascular diseases, trauma, CSF disorders, developmental malformations, inflammatory diseases, epilepsy, tumors and tumor-like conditions, neurodegenerative diseases, metabolic conditions and neuromuscular disorders.

It sets out the key clinical and imaging features of the various causes of dementia and directs the reader from clinical presentation to neuroimaging and on to an accurate diagnosis whenever possible.

The numerous ways in which man and animals are affected by their physical environment, and the inborn and adaptive responses to change in the "milieu exterieur" have fascinated curious minds since the earliest days of recorded history. Development of the scientific method with its emphasis on evidence obtained through experimentation-perhaps best illustrated in this field by Paul Bert's encyclopedic work-allowed several generations of our predecessors to establish firmly some facts and reject erroneous beliefs, but it was only during the early 1940s that environmental physiology put on its seven-league boots. In 1941, a young physiologist named Hermann Rahn was recruited by Wallace O. Fenn, then Chairman of the Department of Physiology at the University of Rochester, who was engaged in a study of the effects of altitude on human performance. The years that followed witnessed some of Hermann Rahn's early achievements not only in the area of altitude, but in other aspects of environmental physiology as well. In particular, he participated in the definitive studies of human adaptive mechanisms in arid climates which formed the basis of Edward Adolph's classic "Physi­ ology of Man in the Desert" (Wiley/Interscience, NY 1947). During those golden years, environmental physiology flourished, and important dis­ coveries were reported in a seemingly endless stream from many labora­ tories.