Philip Scheltens – författare

Functional magnetic resonance imaging (FMRI) has become the most widely used method for imaging normal brain function in a relatively short period of time. The use of FMRI in clinically related research has been much slower; however, FMRI is now becoming a valuable tool in the study of many neurological and psychiatric disorders.This book explains the status of current clinical applications of FMRI in preoperative evaluation, diagnosis and discrimination of pathology, and in understanding recovery, therapeutics and rehabilitation of neurological and psychiatric conditions. Individual chapters cover the use of FMRI in the preoperative assessment of both motor function and language as well as in the assessment of age-related changes in memory. More focused chapters cover the use of FMRI in specific medical conditions including dementia, schizophrenia, depression and anxiety disorders, stroke, Parkinson's disease and multiple sclerosis. The book concludes with a chapter on the role of FMRI in monitoring changes in brain function following exposure to clinical pharmacotherapeutics and experimental drug compounds. This book will be of interest to both novice FMRI researchers and expert FMRI scientists as well as to clinicans in neurology, radiology and psychiatry.

This issue of Medical Clinics covers the important advances surrounding the early intervention of Alzheimer's Disease. Guest edited by world-renowned experts from around the world, the topics covered will include evaluation of new diagnostic criteria, CSF biomarkers, diagnostic imaging, neurocognitive approaches, breaking clinical trials and more.

This up-to-date, superbly illustrated book is a practical guide to the effective use of neuroimaging in the patient with cognitive decline. It sets out the key clinical and imaging features of the various causes of dementia and directs the reader from clinical presentation to neuroimaging and on to an accurate diagnosis whenever possible.  After an introductory chapter on the clinical background, the available "toolbox" of structural and functional neuroimaging techniques is reviewed in detail, including CT, MRI and advanced MR techniques, SPECT and PET, and image analysis methods. The imaging findings in normal ageing are then discussed, followed by a series of chapters that carefully present and analyze the key findings in patients with dementias. Throughout, a practical approach is adopted, geared specifically to the needs of clinicians (neurologists, radiologists, psychiatrists, geriatricians) working in the field of dementia, for whom this book will prove an invaluable resource.

The numerous ways in which man and animals are affected by their physical environment, and the inborn and adaptive responses to change in the "milieu exterieur" have fascinated curious minds since the earliest days of recorded history. Development of the scientific method with its emphasis on evidence obtained through experimentation-perhaps best illustrated in this field by Paul Bert''s encyclopedic work-allowed several generations of our predecessors to establish firmly some facts and reject erroneous beliefs, but it was only during the early 1940s that environmental physiology put on its seven-league boots. In 1941, a young physiologist named Hermann Rahn was recruited by Wallace O. Fenn, then Chairman of the Department of Physiology at the University of Rochester, who was engaged in a study of the effects of altitude on human performance. The years that followed witnessed some of Hermann Rahn''s early achievements not only in the area of altitude, but in other aspects of environmental physiology as well. In particular, he participated in the definitive studies of human adaptive mechanisms in arid climates which formed the basis of Edward Adolph''s classic "Physi­ ology of Man in the Desert" (Wiley/Interscience, NY 1947). During those golden years, environmental physiology flourished, and important dis­ coveries were reported in a seemingly endless stream from many labora­ tories.

The numerous ways in which man and animals are affected by their physical environment, and the inborn and adaptive responses to change in the "milieu exterieur" have fascinated curious minds since the earliest days of recorded history. Development of the scientific method with its emphasis on evidence obtained through experimentation-perhaps best illustrated in this field by Paul Bert's encyclopedic work-allowed several generations of our predecessors to establish firmly some facts and reject erroneous beliefs, but it was only during the early 1940s that environmental physiology put on its seven-league boots. In 1941, a young physiologist named Hermann Rahn was recruited by Wallace O. Fenn, then Chairman of the Department of Physiology at the University of Rochester, who was engaged in a study of the effects of altitude on human performance. The years that followed witnessed some of Hermann Rahn's early achievements not only in the area of altitude, but in other aspects of environmental physiology as well. In particular, he participated in the definitive studies of human adaptive mechanisms in arid climates which formed the basis of Edward Adolph's classic "Physi­ ology of Man in the Desert" (Wiley/Interscience, NY 1947). During those golden years, environmental physiology flourished, and important dis­ coveries were reported in a seemingly endless stream from many labora­ tories.

This up-to-date, superbly illustrated book is a practical guide to the effective use of neuroimaging in the patient with cognitive decline. It sets out the key clinical and imaging features of the various causes of dementia and directs the reader from clinical presentation to neuroimaging and on to an accurate diagnosis whenever possible.  After an introductory chapter on the clinical background, the available "toolbox" of structural and functional neuroimaging techniques is reviewed in detail, including CT, MRI and advanced MR techniques, SPECT and PET, and image analysis methods. The imaging findings in normal ageing are then discussed, followed by a series of chapters that carefully present and analyze the key findings in patients with dementias. Throughout, a practical approach is adopted, geared specifically to the needs of clinicians (neurologists, radiologists, psychiatrists, geriatricians) working in the field of dementia, for whom this book will prove an invaluable resource.