Harleen Kaur – författare

Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS).

This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization.

Therapeutic Monoclonal Antibodies: From Lot Release to Stability Testing is a highly topical resource on a subject of interest for scientists and researchers working on monoclonal antibodies' characterization, release testing, stability testing and similarity assessments of monoclonal antibodies in the biopharmaceutical industry. Monoclonal antibodies (mAbs) are large, extremely complex and dynamic biomolecules, so it can be challenging to develop well-characterized therapeutic antibodies that meet regulatory expectations that are also in-line with commercialized standards for different drug markets.Lot release testing and understanding the stability of the mAb over a period of time, and in different environmental conditions, is an indispensable aspect of mAb physicochemical characterization. This book covers the process, including extensive analysis that starts with quantifying the purity attribute to glycan profiling and identifying the mAb primary structure. The book has a primary purpose of focusing on both Lot release testing and stability testing of monoclonal antibodies (subjects not covered in any great detail in other books).

Based on the IOM''s estimate of 44,000 deaths annually, medical errors rank as the eighth leading cause of death in the U.S. Clearly medical errors are an epidemic that needs to be contained. Despite these numbers, patient safety and medical errors remain an issue for physicians and other clinicians. This book bridges the issues related to patient safety by providing clinically relevant, vignette-based description of the areas where most problems occur. Each vignette highlights a particular issue such as communication, human facturs, E.H.R., etc. and provides tools and strategies for improving quality in these areas and creating a safer environment for patients.

Based on the IOM''s estimate of 44,000 deaths annually, medical errors rank as the eighth leading cause of death in the U.S. Clearly medical errors are an epidemic that needs to be contained. Despite these numbers, patient safety and medical errors remain an issue for physicians and other clinicians. This book bridges the issues related to patient safety by providing clinically relevant, vignette-based description of the areas where most problems occur. Each vignette highlights a particular issue such as communication, human facturs, E.H.R., etc. and provides tools and strategies for improving quality in these areas and creating a safer environment for patients.

Buying decision making is a complicated process, in which a consumer’s decision is under the influence of others. The buyer’s decision making is directed in such a way that they must act as a consumer in society. Media and family are key socializing agents for adolescents. Moreover, changes in the socio-cultural environment in India necessitate that adolescents’ influence in family’s buying decision making should be investigated. In comparison to Western society, Indian society is quite different when compared in terms of family composition and structure, behavior, values and norms which impact adolescents’ buying decision making.

Adolescents, Family and Consumer Behaviour studies the role of consumer socialization agents for adolescents, examining socio-economic factors that influence adolescents’ buying decision making in Indian urban families. It aims to discover the influence tactics that adolescents employ and to qualitatively analyse how marketers in turn influence adolescents. It addresses the topics with regard to strategic management and marketing and will be of interest to researchers, academics, practitioners, and students in the fields of management, entrepreneurship, small business management, and human resource management.

Buying decision making is a complicated process, in which a consumer’s decision is under the influence of others. The buyer’s decision making is directed in such a way that they must act as a consumer in society. Media and family are key socializing agents for adolescents. Moreover, changes in the socio-cultural environment in India necessitate that adolescents’ influence in family’s buying decision making should be investigated. In comparison to Western society, Indian society is quite different when compared in terms of family composition and structure, behavior, values and norms which impact adolescents’ buying decision making.

Adolescents, Family and Consumer Behaviour studies the role of consumer socialization agents for adolescents, examining socio-economic factors that influence adolescents’ buying decision making in Indian urban families. It aims to discover the influence tactics that adolescents employ and to qualitatively analyse how marketers in turn influence adolescents. It addresses the topics with regard to strategic management and marketing and will be of interest to researchers, academics, practitioners, and students in the fields of management, entrepreneurship, small business management, and human resource management.

Various Multiple Criteria Decision-Making (MCDM) techniques in one book: 13 MCDM techniques have been applied, namely, WSM, WPM, WASPAS, GRA, SMART, CRITIC, ENTROPY, EDAS, MOORA, AHP, TOPSIS, VIKOR, and new tools: MDEMATEL, Fuzzy MDEMATEL, Modified Fuzzy TOPSIS and Modified Fuzzy VIKOR. To date, no other book possesses this many tools.

Various quantitative techniques: Different quantitative techniques have been applied, namely, Cronbach alpha, Chi-square and ANOVA (for demographic analysis), Percent Point Score and Central Tendency (response analysis), Factor Analysis, Correlation and Regression. To date, no other book possesses this many tools.

Interpretive Structural Modelling: ISM has been applied for verifying MCDM results through MICMAC analysis and ISM model thus paving the way for model through SEM. Structural Equation Modelling: SEM using AMOS in PASW has been applied for model development.

New MCDM techniques developed: In the process during qualitative analysis, new tools have been developed and their results have been compared with other existing MCDM tools and the results are encouraging. The new techniques are MDEMATEL, Fuzzy MDEMATEL, Modified Fuzzy TOPSIS and Modified Fuzzy VIKOR.

Qualitative Model Developed: As the title says, Sustainable Green Development and Manufacturing Performance through Modern Production Techniques. It is a need-of-the-hour topic, as industries must maintain their performance (sustainable development) and, while sustaining, they have to keep in mind green issues (that is, environment-related issues, especially during the COVID-19 pandemic) and adopt advanced manufacturing and maintenance techniques. A model for this has been developed which will be helpful to both academicians and industrialists.

Real-time Case Studies: Case studies in two industries of differing origins, different manufacturing sectors, different products, and comparing their units in the country of their origin and India.

Dr. Chandan Deep Singh is an assistant professor in the Department of Mechanical Engineering, Punjabi University, Patiala, Punjab (India). He is a co-author of Adolescents, Family and Consumer Behaviour (Routledge, 2020) and of Manufacturing Competency and Strategic Success in the Automobile Industry (CRC Press, 2019).

Dr. Harleen Kaur is a manager (HR) at DELBREC Industries, Pvt. Ltd., Chandigarh. She co-authored Adolescents, Family and Consumer Behaviour (Routledge, 2020).

Various Multiple Criteria Decision-Making (MCDM) techniques in one book: 13 MCDM techniques have been applied, namely, WSM, WPM, WASPAS, GRA, SMART, CRITIC, ENTROPY, EDAS, MOORA, AHP, TOPSIS, VIKOR, and new tools: MDEMATEL, Fuzzy MDEMATEL, Modified Fuzzy TOPSIS and Modified Fuzzy VIKOR. To date, no other book possesses this many tools.

Various quantitative techniques: Different quantitative techniques have been applied, namely, Cronbach alpha, Chi-square and ANOVA (for demographic analysis), Percent Point Score and Central Tendency (response analysis), Factor Analysis, Correlation and Regression. To date, no other book possesses this many tools.

Interpretive Structural Modelling: ISM has been applied for verifying MCDM results through MICMAC analysis and ISM model thus paving the way for model through SEM. Structural Equation Modelling: SEM using AMOS in PASW has been applied for model development.

New MCDM techniques developed: In the process during qualitative analysis, new tools have been developed and their results have been compared with other existing MCDM tools and the results are encouraging. The new techniques are MDEMATEL, Fuzzy MDEMATEL, Modified Fuzzy TOPSIS and Modified Fuzzy VIKOR.

Qualitative Model Developed: As the title says, Sustainable Green Development and Manufacturing Performance through Modern Production Techniques. It is a need-of-the-hour topic, as industries must maintain their performance (sustainable development) and, while sustaining, they have to keep in mind green issues (that is, environment-related issues, especially during the COVID-19 pandemic) and adopt advanced manufacturing and maintenance techniques. A model for this has been developed which will be helpful to both academicians and industrialists.

Real-time Case Studies: Case studies in two industries of differing origins, different manufacturing sectors, different products, and comparing their units in the country of their origin and India.

Dr. Chandan Deep Singh is an assistant professor in the Department of Mechanical Engineering, Punjabi University, Patiala, Punjab (India). He is a co-author of Adolescents, Family and Consumer Behaviour (Routledge, 2020) and of Manufacturing Competency and Strategic Success in the Automobile Industry (CRC Press, 2019).

Dr. Harleen Kaur is a manager (HR) at DELBREC Industries, Pvt. Ltd., Chandigarh. She co-authored Adolescents, Family and Consumer Behaviour (Routledge, 2020).

The book provides insight into various technologies adopted and to be adopted in the future by industries and measures the impact of these technologies on manufacturing performance and their sustainability.

Businesses and manufacturers face a slew of demands beyond the usual issues of staying agile and surviving in a competitive landscape within a rapidly changing world. Factories of the Future deftly takes the reader through the continuous technology changes and looks ten years down the road at what manufacturing will mostly look like.

The book is divided into two parts: Emerging technologies and advancements in existing technologies. Emerging technologies consist of Industry 4.0 and 5.0 themes, machine learning, intelligent machining, advanced maintenance, reliability, and green manufacturing. The advances of existing technologies consist of digital manufacturing, artificial intelligence in machine learning, Internet of Things, product life cycle, and the impact of factories on the future of manufacturing performance of the manufacturing industries.

Readers will find in this illuminating book:

The book provides insight into various technologies adopted and to be adopted in the future by industries and measures the impact of these technologies on manufacturing performance and their sustainability.

Businesses and manufacturers face a slew of demands beyond the usual issues of staying agile and surviving in a competitive landscape within a rapidly changing world. Factories of the Future deftly takes the reader through the continuous technology changes and looks ten years down the road at what manufacturing will mostly look like.

The book is divided into two parts: Emerging technologies and advancements in existing technologies. Emerging technologies consist of Industry 4.0 and 5.0 themes, machine learning, intelligent machining, advanced maintenance, reliability, and green manufacturing. The advances of existing technologies consist of digital manufacturing, artificial intelligence in machine learning, Internet of Things, product life cycle, and the impact of factories on the future of manufacturing performance of the manufacturing industries.

Readers will find in this illuminating book:

Condition-Based Maintenance and Residual Life Prediction is essential for those looking to effectively implement condition-based maintenance strategies and enhance fault detection through a comprehensive understanding of vibration data analysis and residual life prediction, addressing key challenges in the field.

Issues related to condition-based maintenance include its high initial cost, new techniques that can be difficult to implement due to resistance, older equipment that can be difficult to retrofit with sensors and monitoring equipment, and difficult-to-access equipment during production that is difficult to spot-measure. Keeping the above issues in mind, a general handbook for condition-based maintenance and residual life prediction is required to carry out in fault detection.

Condition-Based Maintenance and Residual Life Prediction aims to develop, analyze, and model condition-based maintenance and residual life prediction through vibration data. The analysis of vibration responses will aid in developing a fault detection system. The sources of vibration may be due to the presence of different types of defects, such as cracks in the shaft, a bent shaft, or misalignment of shafts. This will give designers a diagnostic tool for predicting the trends of vibration conditions, leading to early fault detection. The devised tool will be capable of quantifying the amplitude of vibration based on the severity of defects. With the features available in the devised diagnostic tool, the proposed model can be used for design, predictive maintenance, and condition-based maintenance.

Condition-Based Maintenance and Residual Life Prediction is essential for those looking to effectively implement condition-based maintenance strategies and enhance fault detection through a comprehensive understanding of vibration data analysis and residual life prediction, addressing key challenges in the field.

Issues related to condition-based maintenance include its high initial cost, new techniques that can be difficult to implement due to resistance, older equipment that can be difficult to retrofit with sensors and monitoring equipment, and difficult-to-access equipment during production that is difficult to spot-measure. Keeping the above issues in mind, a general handbook for condition-based maintenance and residual life prediction is required to carry out in fault detection.

Condition-Based Maintenance and Residual Life Prediction aims to develop, analyze, and model condition-based maintenance and residual life prediction through vibration data. The analysis of vibration responses will aid in developing a fault detection system. The sources of vibration may be due to the presence of different types of defects, such as cracks in the shaft, a bent shaft, or misalignment of shafts. This will give designers a diagnostic tool for predicting the trends of vibration conditions, leading to early fault detection. The devised tool will be capable of quantifying the amplitude of vibration based on the severity of defects. With the features available in the devised diagnostic tool, the proposed model can be used for design, predictive maintenance, and condition-based maintenance.

Unlock the transformative potential of the Metaverse with this crucial book that delves into vital information, security concerns, and innovative applications that can significantly enhance personalized patient care in a rapidly evolving digital landscape.

This book explores insights into information security concerns, preventive measures, and their impact on healthcare applications in the Metaverse. The Metaverse is an amplified virtual world derived from the conjunction of virtual and physical space, where users can interact in an augmented world to meet each other virtually and engage in virtual activities that give authentic practice. The healthcare industry will tremendously benefit from this technology by using it to enhance personalized care for clients. Public health experts believe that while much has been said about the potential of the Metaverse in the entertainment and gaming industry, healthcare is another industry where its impact could be transformational. This volume provides a better understanding of healthcare applications in the Metaverse and why digital information security is of major concern. Recently, the world saw the impacts of the COVID-19 pandemic, which physically stopped mobility. Life is taken care of using digital interactions and the movement of information digitally through the Metaverse. This book explores implementation issues and performance evaluations of emerging technologies, along with research results and networking methods to demonstrate the immense benefits of this emerging technology.

Readers will find this book:

Audience

Researchers, students, educators, and healthcare professionals focused on information communication technologies and their benefits in healthcare.

This book attempts to create awareness about the UN-MDGs and how various ICT can be harnessed to appeal to different demographics. Current empirical evidence suggests that MDG awareness is relatively low particularly in developed countries, and that the levels of MDG awareness vary considerable across socioeconomic variables or demographics from United Nations perspective. It also examines how ICT can be used to bring about technical and social innovations strengthen livelihoods, support economic development, water and climate resilience and improve the education and health sectors and enhance development opportunities. Several studies are highlighted that reinforce the view that government support and private sector expertise and funding are important factors in ICT-based e-government solutions in developing countries.

The book also builds on the thesis that a strong connection between competencies in mathematics, science, and information communication/technology is required to build logical concepts and critical thinking skills. It also examines the opportunities and barriers of promoting students’ learning skills, including communication, cooperation, collaboration and connection using the Wiki tool under the blackboard platform. Finally, the book also highlights the challenges involved in application of ICT in education. This is significant for educators in order to surmount these obstacles and consequently successfully incorporate ICT into the educational system.

The chapters present the relevant literature on ICTs and the perceived barriers to ICT integration in basic education. They also focus on the implications of incorporating ICT in the basic educational system. The challenges confronting the integration of ICT in education are equally identified with a view to ensuring a more efficient application of ICT in attaining education for all.