Howard Adler – författare

Advances in Radiation Biology, Volume 9, provides an overview of the state of knowledge in radiation biology. The book contains nine chapters and begins with a study on the ways in which physical and chemical agents might trigger "regulatory dysfunction" and how these agents might interact with each other. This is followed by separate chapters on the mechanisms underlying changes in vascular function after doses of radiation in the therapeutic range and their role in the development of late effects in normal tissues; the future of hypoxic cell sensitizers in the clinical setting; DNA strand break formation by ionizing radiation; and major pathways which result in radiation-induced loss of cellular proliferative capacity. Subsequent chapters deal with the solid-state radiation chemistry of DNA; radiosensitivity of proliferating mammalian cells; the use of microwave/radiofrequency energy cancer treatment; and the decline of basic radiobiology.

Advances in Radiation Biology, Volume 8, provides an overview of the state of knowledge in the field of radiation biology. The book contains nine chapters and opens with a study on aspects of oxygen enhancement ratio and relative biological effectiveness that are relevant to neutron therapy. This is followed by separate chapters on the clinical application of negative pi mesons; the clinical features and cellular and biochemical defects in human diseases, with an emphasis on defects in DNA metabolism, particularly DNA repair; recombination in eukaryotes; and the principal mechanisms of DNA damage and repair in higher plants. Subsequent chapters deal with the effect of oxygen on the repair of radiation damage by cells and tissues; the effects of ionizing radiation on mammalian cells; heritable lesions affecting populations of irradiated mammalian cells; and environmental impact of tritium.

Advances in Radiation Biology, Volume 7, provides an overview of the state of knowledge in the field of radiation biology. The book contains six chapters and opens with a study on the exploitation of the unique properties of purified lesion-recognizing enzymes as the basis of assays that monitor the repair of DNA lesions in vivo. This is followed by separate chapters on the effects of radiation on living eukaryotic cells; the ecological effects of ionizing radiation; and the applicability of bacterial models of DNA repair and recovery to UV-irradiated mammalian cells. Subsequent chapters focus on acute radiation effects on the adult nervous system and the repair of DNA modified by cytotoxic, mutagenic, and carcinogenic chemicals.

Advances in Radiation Biology, Volume 6, provides an overview of the state of knowledge in the field of radiation biology. The book contains eight chapters and opens with a study on the nature of radiation effects on nucleic acid metabolism in mammalian cells. This is followed by separate chapters on the nature of UV effects on transcriptional functions; interrelationships between ionizing radiation, protein synthesis, and the physiological expressions of radiation damage; and correlation of DNA repair activities and cellular effects in irradiated mammalian cells. Subsequent chapters deal with the interaction of heat and radiation on an in vitro and an in vivo system; the role of hyperthermia for cancer therapy; thermal potentiation of mammalian cell killing; and autologous stem-cell banks for restoring hemopoiesis.

Advances in Radiation Biology, Volume 5 focuses on the various phases of development in radiation biology. This book discusses the radiobiological implications of statistical variations in energy deposition by ionizing radiations; fundamental physics of energy deposition; and radiological assessment of nuclear power stations. The environmental transport of released radionuclides; effects of continuous irradiation on animal populations; and radiation-induced life-shortening and premature aging are also deliberated. This text likewise covers the production of radiation damage in a heterogeneous system; radical identification by EPR; redistribution of cells through the division cycle; and iso-effect formulas. This publication is valuable to radiation biologists, including those interested in radiobiology.