Jerry F. Hardisty – författare

Over the past few decades, there has been an exponential growth of interest in the field of toxicologic pathology, a critical field in safety science, particularly as related to its impact on nonclinical safety in global drug development and care of the environment. Photomicrographic examples of selected nonproliferative and proliferative lesions are necessary to complement the written narratives in textbooks on toxicologic pathology. Toxicologic Pathology: An Atlas fits that need with input provided by top experts in the field. It will become a valuable reference, not only for toxicologic pathologists, but also for a wide variety of nonclinical safety scientists, especially in the pharmaceutical and biotech industries.This book provides illustrations and descriptions of commonly observed findings in toxicologic pathology (i.e., over 1100 photomicrographic examples). These illustrations add visual context to the terms and descriptions commonly used in the field. The illustrations and accompanying descriptions were prepared and peer reviewed by editors and contributors who are known experts in toxicologic pathology, toxicology, and drug development. The Atlas is designed to be practical, easy to use and written with the hope that it will become a reliable "go-to" reference that will be of interest to students and nonscientists (e.g., individuals serving on animal care and use committees) as a key, single source to understanding terminology and visualizing tissue changes described by toxicologic pathologists.

Over the past few decades, there has been an exponential growth of interest in the field of toxicologic pathology, a critical field in safety science, particularly as related to its impact on nonclinical safety in global drug development and care of the environment. Photomicrographic examples of selected nonproliferative and proliferative lesions are necessary to complement the written narratives in textbooks on toxicologic pathology. Toxicologic Pathology: An Atlas fits that need with input provided by top experts in the field. It will become a valuable reference, not only for toxicologic pathologists, but also for a wide variety of nonclinical safety scientists, especially in the pharmaceutical and biotech industries.This book provides illustrations and descriptions of commonly observed findings in toxicologic pathology (i.e., over 1100 photomicrographic examples). These illustrations add visual context to the terms and descriptions commonly used in the field. The illustrations and accompanying descriptions were prepared and peer reviewed by editors and contributors who are known experts in toxicologic pathology, toxicology, and drug development. The Atlas is designed to be practical, easy to use and written with the hope that it will become a reliable "e;go-to"e; reference that will be of interest to students and nonscientists (e.g., individuals serving on animal care and use committees) as a key, single source to understanding terminology and visualizing tissue changes described by toxicologic pathologists.

Over the past few decades, there has been an exponential growth of interest in the field of toxicologic pathology, a critical field in safety science, particularly as related to its impact on nonclinical safety in global drug development and care of the environment. Photomicrographic examples of selected nonproliferative and proliferative lesions are necessary to complement the written narratives in textbooks on toxicologic pathology. Toxicologic Pathology: An Atlas fits that need with input provided by top experts in the field. It will become a valuable reference, not only for toxicologic pathologists, but also for a wide variety of nonclinical safety scientists, especially in the pharmaceutical and biotech industries.This book provides illustrations and descriptions of commonly observed findings in toxicologic pathology (i.e., over 1100 photomicrographic examples). These illustrations add visual context to the terms and descriptions commonly used in the field. The illustrations and accompanying descriptions were prepared and peer reviewed by editors and contributors who are known experts in toxicologic pathology, toxicology, and drug development. The Atlas is designed to be practical, easy to use and written with the hope that it will become a reliable "e;go-to"e; reference that will be of interest to students and nonscientists (e.g., individuals serving on animal care and use committees) as a key, single source to understanding terminology and visualizing tissue changes described by toxicologic pathologists.

As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Safety Assessment presents a histopathologic description of lesions observed during drug development and discusses their implication in the drug development process. Divided into two sections, the book systematically assists pathologists in making a determination as to the origin and potential importance of a lesion and its relevance for assessing human risk. The first section includes eight "concept" chapters to orient pathologists in areas that are important for effective interaction with other pathologists as well as the many non-pathologists involved in drug development. The second section is made up of organ-based chapters, each including light microscopic and electron microscopic descriptions of pathological lesions, differential diagnoses, biological consequences, pathogenesis, mechanism of lesion formation, and the expected clinical pathology correlates. This volume presents critical information—both published and unpublished and gained through personal experience—to improve the quality of drug safety evaluation and to expedite and improve the efficiency of the process. This book is crafted to assist students, residents, and toxicologic pathologists in their early career phase by serving as a resource that can effectively be used as a ready reference next to the microscope. In addition, more experienced pathologists will find this volume to be invaluable during their assessments. The book is also a valuable reference for toxicologists to assist in understanding compound-related pathological findings and to provide background for working on a range of toxicological problems.