Toxicologic Pathology

Nonclinical Safety Assessment, Second Edition

Inbunden, Engelska, 2018

3 066 kr

Tillfälligt slut

Beskrivning

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk.Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.

Produktinformation

Utgivningsdatum:2018-08-27
Mått:178 x 254 x undefined mm
Vikt:2 674 g
Format:Inbunden
Språk:Engelska
Antal sidor:1 244
Upplaga:2
Förlag:Taylor & Francis Inc
ISBN:9781498745307

Utforska kategorier

Mer om författaren

On page 12

Recensioner i media

"...the editors have achieved a truly remarkable feat in pulling together over 70 of the top toxicologic pathologists, the majority of whom are still practicing in their respective fields."This book has much to recommend it to both the experienced toxicologist and toxicologic pathologist and to beginners in the field of drug development. The accumulated knowledge of the contributing authors, much of which has never been published before, makes this a classic that should be in use for many years to come."-John R. Foster, ToxPath Sciences Ltd, Congleton, Cheshire, UK Toxicologic Pathology 2019, Vol. 47(7) 902Full review available at: https://journals.sagepub.com/doi/pdf/10.1177/0192623319861939

Innehållsförteckning

PrefaceAcknowledgmentsEditorsContributorsSection I Concepts in Drug DevelopmentChapter 1 Overview of Drug DevelopmentJames A. Popp and Jeffery A. EngelhardtChapter 2 Nonclinical Safety Evaluation of DrugsThomas M. Monticello and Jeanine L. BussiereChapter 3 Nonclinical Safety Evaluation of Advanced TherapiesTimothy K. MacLachlan, Kendall S. Frazier, and Mercedes SerabianChapter 4 Nonclinical Safety Evaluation of Medical DevicesKathleen A. Funk, Victoria A. Hampshire, and JoAnn C. L. SchuhChapter 5 Pathology and the Pathologist in Pharmaceutical Research and DevelopmentPage R. Bouchard, Christopher J. Clarke, and Dominique BreesChapter 6 Routine and Special Techniques in Toxicologic PathologyDaniel J. Patrick, Matthew L. Renninger, and Peter C. MannChapter 7 Principles of Clinical PathologyNiraj K. Tripathi and Jacqueline M. TarrantChapter 8 Toxicokinetics and Drug DispositionDavid D. ChristChapter 9 Toxicogenomics in Toxicologic PathologyArun R. Pandiri, David E. Malarkey, and Mark J. HoenerhoffChapter 10 Spontaneous Lesions in Control Animals Used in Toxicity StudiesRobert C. Johnson, Robert H. Spaet, Gitte Jeppesen, Ursula Junker, and Robert StullSection II Organ SystemsChapter 11 Gastrointestinal TractJudit E. Markovits, Graham R. Betton, Donald N. McMartin, and Theresa BoulineauChapter 12 Liver, Gallbladder, and Exocrine PancreasRussell C. Cattley, James A. Popp, and Steven L. VonderfechtChapter 13 Respiratory SystemTom P. McKevitt and David J. LewisChapter 14 Urinary SystemKendall S. Frazier and John Curtis SeelyChapter 15 Hematopoietic SystemKristin Henson, Tanasa Osborne, and Gregory S. TravlosChapter 16 The Lymphoid SystemPatrick J. HaleyChapter 17 Bone, Muscle, and ToothJohn L. Vahle, Joel R. Leininger, Philip H. Long, D. Greg Hall, and Heinrich ErnstChapter 18 The Cardiovascular SystemCalvert Louden, David Brott, Chidozie J. Amuzie, Bindu Bennet, and Ronnie ChamanzaChapter 19 Endocrine GlandsRichard A. Peterson, Sundeep Chandra, and Mark J. HoenerhoffChapter 20 Reproductive System and Mammary GlandJustin D. Vidal, Charles E. Wood, Karyn Colman, Katharine M. Whitney, and Dianne M. CreasyChapter 21 SkinZbigniew W. Wojcinski, Lydia Andrews-Jones, Daher Ibrahim Aibo, Rie Kikkawa, and Robert DunstanChapter 22 Nervous SystemMark T. Butt, Alys Bradley, and Robert SillsChapter 23 Special Senses: Eye and EarKenneth A. Schafer, Oliver C. Turner, and Richard A. AltschulerIndex