Michael G. Stabin – Författare

Written by one of the world's leading experts in the field of nuclear medicine dosimetry, this text describes in detail the use of internal dose calculations in the practice of nuclear medicine. While radiation therapy with external sources of radiation always employs calculations of dose to optimize therapy for each patient, this is not routinely conducted in nuclear medicine therapy. As the trend towards an increasing role of dosimetry in therapy planning increases, this book reviews the available methods and technologies available to make this a more common practice. The book begins by covering the mathematical fundamentals of internal dose calculations, and uses sample calculations to demonstrate key principles. The book then moves forward to describe anthropomorphic models, dosimetric models, and types and uses of diagnostic and therapeutic radiopharmaceuticals. The depth of coverage makes it useful reference and guide for researchers performing dose calculations and for physicians considering incorporating dose calculations into the treatment of their cancer patients.

The second course is a more in-depth and applied study of radiation protection, bringing in current materials from the literature, a detailed study of regulations, practice with re- world dose and shielding calculations, and perhaps application in a semest- long student project assigned by the instructor.

If you reveal your secrets to the wind, you should not blame the wind for revealing them to the trees. —From The Prophet by Kahlil Gibran This was a very satisfying book to write, but also perhaps a very dangerous one. After 15 years of building a base of knowledge in radiopharmaceutical dosimetry (under the expert guidance of Evelyn Watson at the Oak Ridge Dosimetry Center), 8 years of teaching radiation protection and dosimetry at the university level (in northeastern Brazil and at Vanderbilt University in the United States), and Photo used with permission. Copyright © OregonVacationBeaches.com. Also see Memorable-Beach-Vacations.com. v vi Preface authoring a number of papers and book chapters on the subject, it was rewarding to write down in a single, organized text nearly all that I have learned on this topic. My deepest desire is that this text will be found useful by members of the nuclear medicine and radiation protection community in formalizing and facilitating such calculations. After learning a technique for performing dose calculations that must be done often, I have often found ways to automate such work in software tools and to make such tools available to others in order to help them shortcut their efforts. One of the greatest rewards I have received in my work has been to see a few of the tools and ideas that I have developed become useful to others in their routine work.

This book covers scientific, clinical, and educational aspects of radiotheranostics in cancer control. Setting the framework, the first volume defines radiotheranostics and describes the history of radionuclide therapy and theranostics, and the biology of cancer. It examines the clinical applications of unconjugated radionuclides, such as ¹³¹I and ²²³Ra, and of radionuclide-conjugated cancer-specific vectors: peptides, small molecules, antibodies, and nanoparticles; introduces clinical trials and drug development; and reviews epidemiological studies and the adverse effects of radionuclide therapy – both radiation injuries and chemical toxicity. It presents the chemistry and physics of radionuclide production, discusses radioactivity measurements and traceability, and addresses important instrumentation aspects: calibration, quantitative imaging, and quality control. Volume I concludes with guidance on the education, training, and competence of a radiotheranostic multidisciplinary team and summarizes the principal physics characteristics of theranostics today – including many to be expanded in the second volume – while offering a glimpse into tomorrow. This volume provides the foundations for the more advanced second volume, which explores dosimetric and radiation safety, aiming to empower medical physicists and demonstrate to the cancer community how to improve cancer control and yield increased patient survival times.It will be a valuable reference for medical and health physicists with basic knowledge of nuclear medicine.Key FeaturesProvides a comprehensive introduction to the topic, presenting readers with thorough treatment in a cohesive two-volume bookPresents a rigorous approach while remaining accessible to students and trainees in the fieldContains consistent and extensive references to allow readers to delve deeper into the subject

This book covers scientific, clinical, and educational aspects of radiotheranostics in cancer control. Setting the framework, the first volume defines radiotheranostics and describes the history of radionuclide therapy and theranostics, and the biology of cancer. It examines the clinical applications of unconjugated radionuclides, such as ¹³¹I and ²²³Ra, and of radionuclide-conjugated cancer-specific vectors: peptides, small molecules, antibodies, and nanoparticles; introduces clinical trials and drug development; and reviews epidemiological studies and the adverse effects of radionuclide therapy – both radiation injuries and chemical toxicity. It presents the chemistry and physics of radionuclide production, discusses radioactivity measurements and traceability, and addresses important instrumentation aspects: calibration, quantitative imaging, and quality control. Volume I concludes with guidance on the education, training, and competence of a radiotheranostic multidisciplinary team and summarizes the principal physics characteristics of theranostics today – including many to be expanded in the second volume – while offering a glimpse into tomorrow. This volume provides the foundations for the more advanced second volume, which explores dosimetric and radiation safety, aiming to empower medical physicists and demonstrate to the cancer community how to improve cancer control and yield increased patient survival times.It will be a valuable reference for medical and health physicists with basic knowledge of nuclear medicine.Key FeaturesProvides a comprehensive introduction to the topic, presenting readers with thorough treatment in a cohesive two-volume bookPresents a rigorous approach while remaining accessible to students and trainees in the fieldContains consistent and extensive references to allow readers to delve deeper into the subject

The first volume addresses the Physics. Chemistry, Biology and Clinical Applications of Radiotheranostics.This book covers scientific, clinical, and educational aspects of radiotheranostics in cancer control. Setting the framework, the first volume defines radiotheranostics and describes the history of radionuclide therapy and theranostics, and the biology of cancer. It examines the clinical applications of unconjugated radionuclides, such as ¹³¹I and ²²³Ra, and of radionuclide-conjugated cancer-specific vectors: peptides, small molecules, antibodies, and nanoparticles; introduces clinical trials and drug development; and reviews epidemiological studies and the adverse effects of radionuclide therapy – both radiation injuries and chemical toxicity. It presents the chemistry and physics of radionuclide production, discusses radioactivity measurements and traceability, and addresses important instrumentation aspects: calibration, quantitative imaging, and quality control. Volume I concludes with guidance on the education, training, and competence of a radiotheranostic multidisciplinary team and summarizes the principal physics characteristics of theranostics today – including many to be expanded in the second volume – while offering a glimpse into tomorrow. This volume provides the foundations for the more advanced second volume, which explores dosimetric and radiation safety, aiming to empower medical physicists and demonstrate to the cancer community how to improve cancer control and yield increased patient survival times.It will be a valuable reference for medical and health physicists with basic knowledge of nuclear medicine.The second volume covers Radiation Chemistry, Radiation biology, Dosimetry, Safety, Economics and Artificial Intelligence aspects of Radiotheranostics.The book expands upon the radiotheranostic topics in cancer care covered in Volume I, which includes cancer biology, clinical applications, radionuclide production, source calibration, imaging instrumentation, and staff education, training, and competencies. Building on these foundational elements, Volume II offers in-depth coverage of radiopharmaceutical preparation and radiolabeling strategies. It presents new insights into radiation biology, including studies on human and animal radiation embryology. The dosimetry section addresses alpha-, beta-, and Auger-emitting radionuclides and explores the therapeutic potential of positrons. It emphasizes biokinetic modeling, standardized and image-based dosimetry procedures, and the quantification of uncertainties in dose calculations. Essential safety topics are also thoroughly examined, including radiation shielding, facility design, the management of deceased radiotheranostic patients, and current regulatory requirements. The volume concludes with forward-looking chapters on the economics of theranostics and the transformative role of artificial intelligence in enhancing precision medicine. The chapters are designed to equip medical physicists with the tools necessary to accurately estimate and document individual patient dosimetry and demonstrate the clinical value of dose calculations in improving cancer outcomes and survival rates. The book is intended for academic and practicing clinical medical and health physicists with a basic knowledge of nuclear medicine. Although not structured as a textbook, medical physicists in nuclear medicine physics training will also find the book helpful.Key Features:Provides a comprehensive introduction to the topic, presenting readers with thorough treatment in a cohesive two-volume book.Presents a rigorous approach while remaining accessible to students and trainees in the field.Contains consistent and extensive references to allow readers to delve deeper into the subject.

The second course is a more in-depth and applied study of radiation protection, bringing in current materials from the literature, a detailed study of regulations, practice with re- world dose and shielding calculations, and perhaps application in a semest- long student project assigned by the instructor.