Michael S. Roberts – författare

Recent advances in our understanding of the development and morphology of normal skin have led to improved methods to deliver therapeutic compounds to selected targeted areas both within the skin and systemically. This reference provides a clear overview of pharmaceutical and cosmetic practices, drugs, and therapies to manage and treat major and minor skin disorders. Written for scientists interested in dermatological therapy and marketers of pharmaceutical and cosmetic products, the text is also useful for students developing strong research methods. The book covers drugs used to manage a range of skin disorders and the site where the effect is sought. It examines the efficiency and delivery of topical therapies, including various pharmaceutical therapies. It also explains how percutaneous absorption is affected by age, skin, site, race, skin disease, and damage and product form. Particular emphasis is on novel treatment approaches for major skin diseases and injuries pertaining to wounds and burns.

The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin absorption and the various governmental and industrial programs concerned with skin permeation and toxicity. These include alternative in silico, in vitro, and in vivo strategies to conduct studies for regulatory requirements. To make room for this new expanded content, the editors are publishing a concurrent text entitled: Dermatological and Cosmetic Development with a concentration on subjects concerned with dermatological and cosmetic therapies

Cosmetics are the most widely applied products to the skin and include creams, lotions, gels and sprays. Their formulation, design and manufacturing ranges from large cosmetic houses to small private companies. This book covers the current science in the formulations of cosmetics applied to the skin. It includes basic formulation, skin science, advanced formulation, and cosmetic product development, including both descriptive and mechanistic content with an emphasis on practical aspects.Key Features:Covers cosmetic products/formulation from theory to practiceIncludes case studies to illustrate real-life formulation development and problem solvingOffers a practical, user-friendly approach, relying on the work of recognized experts in the fieldProvides insights into the future directions in cosmetic product developmentPresents basic formulation, skin science, advanced formulation and cosmetic product development

A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristicsDescribes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug dispositionDetails the physiology and barriers to drug delivery for each administration routePresents a historical perspective and a look into the possible future of advanced drug delivery systemsExplores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issuesIncludes comprehensive references and links to the primary literatureEdited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

ORAL DRUG DELIVERY FOR MODIFIED RELEASE FORMULATIONS Provides pharmaceutical development scientists with a detailed reference guide for the development of MR formulations Oral Drug Delivery for Modified Release Formulations is an up-to-date review of the key aspects of oral absorption from modified-release (MR) dosage forms. This edited volume provides in-depth coverage of the physiological factors that influence drug release and of the design and evaluation of MR formulations. Divided into three sections, the book begins by describing the gastrointestinal tract (GIT) and detailing the conditions and absorption processes occurring in the GIT that determine a formulation’s oral bioavailability. The second section explores the design of modified release formulations, covering early drug substance testing, the biopharmaceutics classification system, an array of formulation technologies that can be used for MR dosage forms, and more. The final section focuses on in vitro, in silico, and in vivo evaluation and regulatory considerations for MR formulations. Topics include biorelevant dissolution testing, preclinical evaluation, and physiologically-based pharmacokinetic modelling (PBPK) of in vivo behaviour. Featuring contributions from leading researchers with expertise in the different aspects of MR formulations, this volume: Provides authoritative coverage of physiology, physicochemical determinants, and in-vitro in-vivo correlation (IVIVC)Explains the different types of MR formulations and defines the key terms used in the fieldDiscusses the present status of MR technologies and identifies current gaps in researchIncludes a summary of regulatory guidelines from both the US and the EUShares industrial experiences and perspectives on the evaluation of MR dosage formulationsOral Drug Delivery for Modified Release Formulations is an invaluable reference and guide for researchers, industrial scientists, and graduate students in general areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the fieldDrug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and deliveryAn exploration of the techniques and applications of physiologically based models to drug deliveryDiscussions of oral delivery and pharmacokinetic models and oral site-directed deliveryA review of integrated transdermal delivery and pharmacokinetics in developmentAn examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanismsAlternative endpoints to pharmacokinetics for topical deliveryPerfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.

This two volume Second Edition describes the anatomical, physiological, pharmaceutical, and technological aspects of delivery routes, found in areas like:Oral Ocular Dermal and transdermal VaginalColonic Oral mucosal Nasal PulmonaryProviding insight and critical assessment of the many available and emerging modified release drug delivery systems for their current and future value, topics include: Intellectual property rights and regulatory issues and challengesosmotic systems and Qtrol. Qdis. Matrix Systemsthiolated polymers for CR, Oradur. IDD technology, and chronotherapy technologyOral-lyn™ (RapidMist™ Technology)Dentipatch drug delivery systemORAVESCENT™: a novel technology for the transmucosal delivery of drugsEgalet and COLAL technologies

This two volume Second Edition describes the anatomical, physiological, pharmaceutical, and technological aspects of delivery routes, found in areas like: OralOcularDermal and transdermalVaginalColonicOral mucosalNasalPulmonary Providing insight and critical assessment of the many available and emerging modified release drug delivery systems for their current and future value, topics include: modified drug release landscape; academic, regulatory, and intellectual property viewpointsI-vation Sustained Release Intravitreal SystemViaNase Intranasal Device and controlled particle dispersion technology PlatformMicroneedles for drug delivery, PassPort system, Dot-Matrix technology, ultrasound, iontophoretic and technologies, DiretcHaler Nasal technology, intravaginal ring systems, Supravail, Vagisite, C-Vad™ Vaginal Insert, and ‘Smart’ Vaginal Delivery Systemsthe AERx® Pulmonary Drug Delivery SystemAAD-Adaptive aerosol delivery technologynebulizer technologies and dry powder inhaler systems

This is a 2 volume set. Volume 1 is Dermatological and Cosmeceutical Development: Absorption Efficacy and Toxicity. Recent advances in our understanding of the development and morphology of normal skin has led to improved methods to deliver therapeutic compounds to selected targeted areas both within the skin and systemically. This reference provides a clear overview of current pharmaceutical and cosmetic practices in the management of both major and minor skin disorders, and provides an expansive overview of novel drugs and therapies used to treat these conditions. Written for scientists interested in dermatological therapy and those concerned with the marketing for pharmaceutical and cosmetic products, this text will also prove useful for students developing strong research methods. Volume 2 is Dermal Absorption and Toxicity Assessment, Second Edition The book Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin absorption and the various governmental and industrial programs concerned with skin permeation and toxicity. These include alternative in silico, in vitro, and in vivo strategies to conduct studies for regulatory requirements. To make room for this new expanded content, the editors are publishing a concurrent text entitled: Dermatological and Cosmetic Development with a concentration on subjects concerned with dermatological and cosmetic therapies. Dermal Absorption and Toxicity and Assessment is a completely revised and updated text expanded to include coverage pertaining to innovative research…expands on the specific barrier properties of the skin such as its physical structure, biosensor properties, cutaneous metabolism, skin lipid morphology, and dermal blood and lymphatic flow, examines both the standard established laboratory techniques, for example, diffusion cell technology, and also covers new techniques like cultured skin equivalents, dermal absorption, and risk assessment