P. Nicolopoulou-Stamati - Böcker

The day I became the Flemish Minister for Mobility in 1999, my region of Flanders was one of the poorest students of the “EU class” for traffic safety. This was in spite of a variety of measures taken by previous governments, to improve traffic and safety because of unsafe driving behaviour and to reduce the emissions of traff- related pollutants. In this context, I focussed on one specific aspect of traffic safety: the number of traffic deaths and injuries on the roads. My intention was to raise a broad societal debate on mobility. It seemed to me that the most complex issue was to convince those people who are most intimately related to their cars, to leave their vehicles at home. After decades with slogans such as “My car, my freedom” it is politically impossible to withdraw this “freedom” on the basis of ecological arguments. I often noticed that although the majority of the population wants a cleaner environment, the same majority is convinced that ‘pollution is caused by others’. Moreover, the most important environmental problems tend to appear only in the long term. In contrast, the numerous, mainly young, victims on the road, among them the dead and the seriously injured youngsters from ‘weekend’ accidents are immediately visible. In 2001, Flanders totalled 848 road-accident deaths, 7725 seriously injured persons and 39070 minor injuries, from a total population of 6 million people. These are only the recorded figures.

The scope of environmental impact on reproduction is very large. It aims at covering all aspects of reproductive problems and their links to the environment. Therefore, it deals with female and male reproductive impairments, whatever their severity and their sites, gonad or extra-gonad. For women, effects include direct lesions of the oocyte, with possibilities of chromosomal abnormalities but also malformations of the reproductive tract. Reduced fertility and in some cases total infertility may also result from menstrual irregularities, which can at times include anovulatory cycles. Hormonal changes, even in the absence of menstrual irregularities may also lead to decreased fertility. In addition to congenital malformations, other impairments of the reproductive apparatus may occur, as in the polycystic ovarian syndrome or in endometriosis. Finally one can also include effects during pregnancy leading to spontaneous abortion, preterm delivery still birth or altered sex ratio. Impacts on age at menarche and age at menopause lead to a change in the duration of reproductive life.

In recent years, increasing attention and resources have been brought to bear on the relationship between the environment and congenital diseases. These diseases were previously thought to be mostly due to genetic causes. Even though the importance of genes as factors in causation is accepted, environmental factors seem to be implicated just as strongly. This book explores some further concepts that have arisen from more recent perceptions of environmental effects and their possible interactions with living systems. Amongst the topics discussed are:-effects of prenatal exposure to toxic chemicals-intra-uterine exposure to drugs-effects of endocrine disrupters-environmental risk and sex ratio in newborns-surveillance of environmental impact-research and policy.Discussion and presentation of old and novel ideas is targeted at developing a more holistic and united perception of the interaction between congenital diseases and the environment.

The day I became the Flemish Minister for Mobility in 1999, my region of Flanders was one of the poorest students of the “EU class” for traffic safety. This was in spite of a variety of measures taken by previous governments, to improve traffic and safety because of unsafe driving behaviour and to reduce the emissions of traff- related pollutants. In this context, I focussed on one specific aspect of traffic safety: the number of traffic deaths and injuries on the roads. My intention was to raise a broad societal debate on mobility. It seemed to me that the most complex issue was to convince those people who are most intimately related to their cars, to leave their vehicles at home. After decades with slogans such as “My car, my freedom” it is politically impossible to withdraw this “freedom” on the basis of ecological arguments. I often noticed that although the majority of the population wants a cleaner environment, the same majority is convinced that ‘pollution is caused by others’. Moreover, the most important environmental problems tend to appear only in the long term. In contrast, the numerous, mainly young, victims on the road, among them the dead and the seriously injured youngsters from ‘weekend’ accidents are immediately visible. In 2001, Flanders totalled 848 road-accident deaths, 7725 seriously injured persons and 39070 minor injuries, from a total population of 6 million people. These are only the recorded figures.

The scope of environmental impact on reproduction is very large. It aims at covering all aspects of reproductive problems and their links to the environment. Therefore, it deals with female and male reproductive impairments, whatever their severity and their sites, gonad or extra-gonad. For women, effects include direct lesions of the oocyte, with possibilities of chromosomal abnormalities but also malformations of the reproductive tract. Reduced fertility and in some cases total infertility may also result from menstrual irregularities, which can at times include anovulatory cycles. Hormonal changes, even in the absence of menstrual irregularities may also lead to decreased fertility. In addition to congenital malformations, other impairments of the reproductive apparatus may occur, as in the polycystic ovarian syndrome or in endometriosis. Finally one can also include effects during pregnancy leading to spontaneous abortion, preterm delivery still birth or altered sex ratio. Impacts on age at menarche and age at menopause lead to a change in the duration of reproductive life.